Central Manchester University Hospitals NHS Foundation Trust

Dr Frank Renaud was employed at Manchester Royal Infirmary as honorary physician (1848–1866) and consulting physician (1866–1902). The Infirmary, Manchester Convalescent Home, St Mary's, the Royal Eye Hospital, the Dental Hospital and the Foot Hospital in Manchester were entitled The United Manchester Hospitals when they were taken into the National Health Service in 1948 and run by one hospital management committee. Sir Mike Deegan was Chief Executive from 2001.

Central Manchester University Hospitals NHS Foundation Trust merged with University Hospital of South Manchester NHS Foundation Trust to form Manchester University NHS Foundation Trust on 1 October 2017 as proposed in a report by Sir Jonathan Michael.

The Manchester Diabetic Centre was established in 1988 by Professor Stephen Tomlinson and Jill Pooley, one of the first diabetes specialist nurses in the country. It was deliberately sited outside the main hospital building on Hathersage Road at the southern end of the Oxford Road site. It included other paramedics such as chiropodists and dieticians so it could deliver a one-stop shop for diabetic care. Tomlinson argued that the new way of providing care would prevent secondary conditions such as diabetic foot.

The Manchester Sickle Cell Centre was established in 1984 – also off the main site, on the opposite side of Oxford Road from the main building. It was renamed as the Sickle-Cell and Thalassaemia Centre in 1991.

As the leading provider of tertiary and specialist healthcare services in Manchester, It treated more than a million patients every year. On 1 April 2011, community services previously provided by the primary care trust transferred to the trust as part of the Transforming Community Services initiative.

It is one of the biggest provider of specialised services in England, which generated an income of £334.7 million in 2014/5. The transplant team carried out 317 transplants in 2015, the most of any centre in the UK.