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Maurice Merleau-Ponty (1908–1961), philosopher.
Henri Maldiney (1912-2013), philosopher.
Gilles Deleuze (1925–1995), philosopher. Taught at the School of Philosophy from 1965 to 1969.
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After division of University of Lyon
Guy Achard (born 1936), Roman historian
Mauro Carbone (born 1956), philosopher
Denis Crouzet (born 1953), historian
Michel Durafour (1920-2017), economist; centrist politician
Régis Debray (born 1940), philosopher; intellectual, journalist, left-wing government official.
Tristan Garcia (born 1981), philosopher and novelist
Geneviève Gobillot, scholar of Islam
Bruno Gollnisch (born 1950), professor of Japanese language and civilisation; far-right politician
Serge Guinchard (born 1946), jurist, later professor emeritus at Université Panthéon-Assas.
Gilles Guyot (born 1946), professor of management
Jean Haudry (1934-2023), professor of Sanskrit; far-right politician
Hubert Julien-Laferrière (born 1966), economist; center-left politician
Blandine Kriegel (born 1943), professor of philosophy
Bernard Lugan (born 1946), professor of African history; far-right politician
Jean-François Mayer (born 1957), religious historian
Michel Mercier (born 1947), center-right politician, former minister of Justice (2010 until 2012)
Pierre-Jean Souriac, historian
László Trócsányi (born 1956), Hungarian lawyer and politician
Jean Varenne (1926–1997), Indologist; far-right politician
Pierre Vial (born 1942), medievalist; far-right politician
Gérard E. Weil (1926–1986), biblical scholar
Shawn Wong (born 1949) – American professor of creative writing
Prior to division of University of Lyon
Georges Chapouthier (born 1945), neuroscientist and philosopher.
Anne-Marie Escoffier (born 1942), socialist politician
Frantz Fanon (1925–1961), psychiatrist, philosopher, revolutionary and writer whose work is influential in the field of post-colonial studies.
Antoine Ghanem (1943–2007), Lebanese politician and an MP in the Lebanese Parliament.
Serge Guinchard (born 1946), jurist, professor emeritus at Université Panthéon-Assas.
Motono Ichirō (1862–1918), statesman and diplomat, former foreign minister of Japan
Louis Josserand (1868–1941), legal scholar, council at Court of Cassation
Ume Kenjirō (1860–1910), drafter of the Japanese civil code, and a founder of Hosei University
Dominique Perben (born 1945), former minister of Justice (2002–2005), and minister of transportation (2005–2007).
François Perroux (1903–1987), economist, professor at the Collège de France
After division of University of Lyon
Reine Alapini-Gansou (born 1956), judge on the International Court of Justice.
Étienne Blanc (born 1954), conservative politician (LR)
Frigide Barjot (born 1962), humorist, and conservative political activist
Farès Boueiz (born 1955), Lebanese lawyer and politician
Frank Bournois (born 1962), business academic
Thierry Braillard (born 1964), center-left politician and former minister of Sports.
Dominique Dord (born 1959), conservative politician, member of the National Assembly of France.
Coralie Dubost (born 1983), lawyer, center politician (La République En Marche!)
Audrey Dufeu-Schubert (born 1980), center politician (La République En Marche!)
Georges Fenech (born 1954), judge and conservative politician (UMP)
Kadra Ahmed Hassan (born 1973), permanent representative of Djibouti to the United Nations at Geneva
Michel Havard (born 1967), conservative politician (UMP)
Anne Hidalgo (born 1959), Mayor of Paris (2014-2026), member of the Socialist Party
Seyed Mohammad Hosseini (born 1963), Iraqi diplomat.
Andrew Hussey (born 1963), historian of French culture
Alain Jakubowicz (born 1953), lawyer, human rights activist and politician, former president of the International League Against Racism and Anti-Semitism
Dalia Kreivienė (born 1972), Lithuanian diplomat
Patrick Louis (born 1955), far-right politician and member of the European Parliament
Gwei Lun-mei (born 1983), Taiwanese actress.
Jean-François Mayer (born 1957), historian of religion
Michel Mercier (born 1947), center-right former minister of Justice (2010 until 2012)
Yves Nicolin (born 1963), conservative politician (UMP)
Jacqueline Oble (born 1950), Ivorian lawyer and politician
Meg Otanwa, Nigerian actress
Walid Phares (born 1957), Donald Trump's foreign policy adviser, Lebanese-American scholar and analyst for MSNBC, professor at National War College (NWC)
Julien Rochedy (born 1988), French far-right politician
Sylvie Tellier (born 1978), Miss France 2002, lawyer, national director of both Miss France and Miss Europe Organization
Yacouba Isaac Zida (born 1965), former Prime Minister of Burkina Faso.