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Private company

Lewis Drug

Logo: lewisdrug.com3

American drug store chain

Lewis Drug is an American, Sioux Falls, South Dakota based operator of 59 drugstores under the Lewis Drug and the Lewis Family Drug banners in South Dakota, Minnesota, and Iowa.2 Wikipedia text CC BY-SA 4.0

Last updated Oct 21, 2026.

Overview

1942Founded1

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Lewis Drug is an American, Sioux Falls, South Dakota based operator of 59 drugstores under the Lewis Drug and the Lewis Family Drug banners in South Dakota, Minnesota, and Iowa.2

How it started

History

Headquartered in Sioux Falls, the company was established in 1942 by partners Jesse Lewis and George Fredrickson. John Griffin joined the business shortly after that and bought out Jesse Lewis in 1946. It was established in 1942 as the first self-service drug store in South Dakota and the surrounding region. Griffin's son Mark became the sole owner in 1984.

In the fall of 2025, Lewis Drug was acquired by Sanford Health for an undisclosed sum. Currently, Lewis Drug retains its original branding, but all employees are a part of Sanford Health.

From Wikipedia’s article on Lewis Drug, shared under CC BY-SA 4.0.2

Timeline

  1. 1942Founded Founded1

Sources

The numbers on this page point here. Each one links to the record it came from.

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    Company websiteLewis Drug logo