James Curtis Hepburn

Hepburn was born in Milton, Pennsylvania, on March 13, 1815. He attended Princeton University, where he earned a master's degree, then attended the University of Pennsylvania, where he received his M.D. degree in 1836, and became a physician. He decided to go to China as a medical missionary, but had to stay in Singapore for two years because the First Opium War was underway and Chinese ports were closed to foreigners. After five years as a missionary, he returned to the United States in 1845 and opened a medical practice in New York City.

In 1859, Hepburn went to Japan as a medical missionary with the American Presbyterian Mission. After first arriving in Nagasaki in October 1859, Hepburn swiftly relocated to the newly opened treaty port of Yokohama, opening his first clinic in April 1861 at the Sōkōji Temple. Initially residing at Jōbutsuji in Kanagawa, a dilapidated temple formerly occupied by the Dutch consulate, Hepburn was the first Christian missionary to take up residence close to the newly opened treaty port. Hepburn's family shared accommodation at Jobutsuji with Dutch Reformed minister Rev. Samuel Robbins Brown and all were quickly absorbed into the local foreign community, Hepburn being appointed honorary physician to the US Consul, Townsend Harris.

Hepburn's first clinic failed as the Bakumatsu authorities, wanting the missionaries to relocate to Yokohama, put pressure on patients to stop going to it. In the spring of 1862, Hepburn and his family relocated to the house and compound at Kyoryūchi No. 39, in the heart of the foreigners residential district in the treaty port of Yokohama. There, in addition to his clinic, he and his wife Clara founded the Hepburn School, which eventually developed into Meiji Gakuin University. Hepburn's Japanese pupils included Furuya Sakuzaemon, Takahashi Korekiyo, Okakura Kakuzō, and Numa Morikazu.

For his medical contributions to the city of Yokohama, Hepburn Hall was named in his honor on the campus of Yokohama City University School of Medicine.

In May 1867, with the collaboration of his long-time assistant Kishida Ginkō, Hepburn published a Japanese–English dictionary which rapidly became the standard reference work for prospective students of Japanese. In the dictionary's third edition, published in 1886, Hepburn adopted a new system for romanization of the Japanese language developed by the Society for the Romanization of the Japanese Alphabet (Rōmajikai). This system is widely known as the Hepburn romanization because Hepburn's dictionary popularized it. Hepburn also contributed to the translation of the Bible into Japanese.