Prince Luigi Amedeo, Duke of the Abruzzi

Prince Luigi was born in Madrid, Spain as the third oldest son of Prince Amadeo of Savoy, Duke of Aosta and his first wife Donna Maria Vittoria dal Pozzo della Cisterna. Prince Luigi Amedeo was a grandson of King Vittorio Emanuele II of Italy. He was born during his father's brief reign as King of Spain. His siblings were Prince Emanuele Filiberto, Prince Vittorio Emanuele, and Prince Umberto. Shortly after his birth, his father, who had reigned in Spain since 1870, abdicated and returned to Italy in 1873. Prince Luigi Amedeo was a member of the House of Savoy, well known in Europe since the 12th century. His uncle became King Umberto I of Italy in 1878, and his cousin became King Vittorio Emanuele III in 1900.

The title Duke of the Abruzzi (Italian: Duca degli Abruzzi) was created by King Umberto I in 1890 for Luigi Amedeo, who was a son of the abdicating King of Spain Amadeus and initially was given the title of Infante of Spain. His ducal title referred to the central Italian region of Abruzzo.

From 1893 to 1896, Luigi Amedeo traveled around the world, including Eritrea, then an Italian possession, and Vancouver. In September 1893, he traveled to Italian Somaliland to quell the unrest and stayed for a month to guard the port of Mogadishu, giving him his first contact with a land to which he would later devote the last years of his life and in which he would choose to die. He had begun to train as a mountaineer in 1892 on Mont Blanc and Monte Rosa (Italian Alps): in 1897 he made the first ascent of Mount Saint Elias (Canada/U.S., 5,489 m). There the expedition searched for a mirage, known as The Silent City of Alaska, that natives and prospectors claimed to see over a glacier. C. W. Thornton, a member of the expedition, wrote: "It required no effort of the imagination to liken it to a city, but was so distinct that it required, instead, faith to believe that it was not in reality a city."

In the early years of the twentieth century, Abruzzi was in a relationship with Katherine Hallie "Kitty" Elkins, daughter of the wealthy American senator Stephen Benton Elkins, but Abruzzi's cousin King Victor Emmanuel III of Italy refused to grant him permission to marry a commoner. His brother, Emanuele Filiberto, to whom Luigi was very close, persuaded him to give up the relationship. His brother later approved of young Antoinette "Amber" Brizzi, the daughter of Quinto Brizzi, one of the largest vineyard owners in Northern Italy. Despite this, Abruzzi was never officially married; however, in the later years of his life, Abruzzi had a relationship and deep romantic partnership with Faduma Ali, a young Somali woman who stayed by his side even while he was on his deathbed.