Samuel H. Wood

Wood completed undergraduate studies in psychology at Loma Linda University in 1979. His graduate training includes a M.A. in psychology from the University of Richmond (1980), an M.D. (1985) and a Ph.D. (1986) from Medical College of Virginia, and an MBA from San Diego State University (1997).

Wood's early scholarship laid the foundation for his future scientific endeavors, beginning with an initial focus on DNA. While attending the Medical College of Virginia, Wood researched isolating a DNA nuclear matrix of HeLa cells using a poly(dT) template. He and his colleagues discovered that HeLa cell primase in these cells is in a bound form and they determined the presence of multiple forms of polymerase α. Wood further studied DNA, in the form of nucleoids, while in his clinical residency in Obstetrics and Gynecology at the University of North Carolina at Chapel Hill. The properties of two types of "subnuclear systems" (preparations of non-DNased-digested nuclei vs. DNased-digested nuclei) were differentiated along with their respective ability to retain elongation in response to increasing concentrations of salt.

Wood then turned his attention to treating premenstrual syndrome (PMS) as well as improving pregnancy rates when using donated eggs. During a fellowship in reproductive endocrinology and infertility, Wood studied the usefulness of fluoxetine (tradename Prozac or Sarafem) for patients experiencing severe PMS. He and his research team found this medication significantly reduced behavioral and physical symptoms during the luteal phase without suffering significant side effects or treatment complications. The collaborators subsequently investigated the efficacy of RU 486 (commonly referred to as "the abortion pill") in treating PMS but found symptoms experienced with administration of low-dose RU 486 to be virtually indistinguishable from subjects receiving a placebo.

Upon opening a private practice, Wood continued to expand the knowledge base in the field of infertility. He and his team analyzed data over a 5-year period for both fresh and frozen egg donation cases with and without use of a gestational surrogate. They found a previously undiscovered "uterine factor" to consider when egg donation resulted in repeated pregnancy failure. Furthermore, they found successful implantation rates were significantly higher for surrogates in both fresh and frozen embryo transfers. Additionally, surrogates showed a significantly higher pregnancy rate following frozen embryo transfers than their non-surrogate counterparts.