Private company

Institute for Systems Biology

American non-profit research institute

The Institute for Systems Biology (ISB) is a non-profit research institution located in Seattle, Washington, United States. ISB concentrates on systems biology, the study of relationships and interactions between various parts of biological systems, and advocates an interdisciplinary approach to biological research.2 It was founded by Leroy Hood, Alan Aderem and Ruedi Aebersold.1 Wikipedia text CC BY-SA 4.0

Last updated Oct 21, 2026.

Overview

2000Founded1
  • HeadquartersSeattle1
  • Websitewww.systemsbiology.org
  • Legal formnon-profit Corporation1
  • LEI549300GAJY38ZVX1UG023
  • StatusActive3
  • LEI statusLapsed (not renewed)3
  • Registered addressC/O CT CORPORATION SYSTEM, 98501-1267 Olympia, United States3
  • Registered withCorporations Division (Office of the Secretary of State), 601 986 3443
Seattle - Institute for Systems Biology 01
Photo: Joe Mabel, CC BY-SA 3.0, via Wikimedia Commons5

The Institute for Systems Biology (ISB) is a non-profit research institution located in Seattle, Washington, United States. ISB concentrates on systems biology, the study of relationships and interactions between various parts of biological systems, and advocates an interdisciplinary approach to biological research.2

The story

Founded by Alan Aderem, Leroy Hood and Ruedi Aebersold in 2000.1

Leroy Hood co-founded the Institute with Alan Aderem and Ruedi Aebersold in 2000.

However, the story of how ISB got started actually begins in 1990. Lee Hood was the director of a large molecular biotechnology lab at the California Institute of Technology in Pasadena, and was a key advisor in the Human Genome Project, having overseen development of machines that were instrumental to its later success. The University of Washington (UW), like many other universities, was eager to recruit Hood, but had neither the space nor the money to accommodate Hood's large laboratory.

Lee Huntsman, director of University of Washington's Center for Bioengineering, was attending a University of Washington football game, sharing a luxury box with Bill Gates, the former CEO and current chairman of Microsoft. Huntsman took the opportunity to tell Gates about Hood. Bill Gates already had a considerable interest in biotechnology, both as a philanthropist and as an investor, and after meeting Hood, donated $12 million to UW to enable him to head a new department of molecular biotechnology, where Hood continues to hold a faculty position as the Gates Professor of Molecular Biotechnology.

ISB represents a spin-off of Hood's labs at UW.

From Wikipedia’s article on Institute for Systems Biology, shared under CC BY-SA 4.0.4

Leadership

Who has led Institute for Systems Biology, and when. Pick a name to see everywhere that person has worked.

Timeline

  1. 2000Founded Founded1

Funding

Where the company's money came from, by calendar year: private offerings filed with the SEC, federal grants, loans, contracts and other assistance from USAspending.gov, and PPP loans from the SBA. Each bar links to the records below.

Money received by year$261.0M 2008–2026
Figures by year
YearFederal grantsPPP loansOther federal assistanceFederal contractsTotal
2026$12.6M–––$12.6M
2025$10.7M–––$10.7M
2024$14.0M–––$14.0M
2023$14.9M–$1.2M$203.5K$16.3M
2022$14.9M–$2.3M$425.0K$17.6M
2021$12.5M–$1.1M–$13.6M
2020$8.7M$3.0M––$11.7M
2019$11.1M–––$11.1M
2018$10.3M––$675.0K$11.0M
2017$4.3M–$1.4M$1.4M$7.1M
2016$9.6M–$1.1M$5.2M$15.9M
2015$6.7M––$7.8M$14.5M
2014$7.4M––$4.0M$11.4M
2013$8.7M––$2.0M$10.6M
2012$8.7M––$2.8M$11.5M
2011$9.0M––$2.7M$11.7M
2010$15.1M––$5.3M$20.4M
2009$14.9M––$2.4M$17.3M
2008$7.2M––$14.8M$22.0M

Federal awards

Obligated amounts from USAspending.gov6, by calendar year, 2008–2026, for its registration. Obligations are what agencies committed, not always what was paid out. Contracts pay for goods and services; grants, loans and direct payments are assistance. Loans are charted at the face value of the loans listed here. An award’s amount below is its lifetime total, and some began before the years charted.

Largest grants

  1. Mar 3, 2006$23.9M from National Institutes of Health: Biomedical Research And Research Training7 To INSTITUTE FOR SYSTEMS BIOLOGY Award P50GM076547
  2. Sep 22, 2022$13.1M from National Institutes of Health: Cancer Centers Support Grants8 To INSTITUTE FOR SYSTEMS BIOLOGY Award U54CA274509
  3. Sep 1, 2015$11.4M from National Institutes of Health: Cancer Centers Support Grants9 To INSTITUTE FOR SYSTEMS BIOLOGY Award U54CA199090
  4. Sep 1, 2010$10.6M from National Institutes of Health: Cancer Detection And Diagnosis Research; Trans-Nih Recovery Act Research Support10 To INSTITUTE FOR SYSTEMS BIOLOGY Award U24CA143835
  5. Dec 1, 2016$8.8M from National Institutes of Health: Allergy And Infectious Diseases Research; Allergy, Immunology And Transplantation Research11 To INSTITUTE FOR SYSTEMS BIOLOGY Award R01AI128215
  6. Aug 15, 2003$7.3M from National Institutes of Health: Human Genome Research12 To INSTITUTE FOR SYSTEMS BIOLOGY Award R01HG002939
  7. Sep 1, 2010$6.0M from National Institutes of Health: Biomedical Research And Research Training13 To INSTITUTE FOR SYSTEMS BIOLOGY Award R01GM087221
  8. Sep 16, 2013$5.8M from National Institutes of Health: Diabetes, Digestive, And Kidney Diseases Extramural Research14 To INSTITUTE FOR SYSTEMS BIOLOGY Award R01DK098449

Largest direct payments

  1. Jan 24, 2020$2.5M from National Institutes of Health: National Center For Advancing Translational Sciences15 To INSTITUTE FOR SYSTEMS BIOLOGY Award OT2TR003443
  2. Sep 22, 2016$2.5M from National Institutes of Health: National Center For Advancing Translational Sciences16 To INSTITUTE FOR SYSTEMS BIOLOGY Award OT3TR002026
  3. Jan 24, 2020$2.0M from National Institutes of Health: National Center For Advancing Translational Sciences17 To INSTITUTE FOR SYSTEMS BIOLOGY Award OT2TR003450

Largest contracts

  1. Sep 15, 2002$19.3M from National Institutes of Health18 To INSTITUTE FOR SYSTEMS BIOLOGY Award 00268200209D268028179
  2. Sep 26, 2008$14.3M from National Institutes of Health: Biomedical (applied/exploratory)19 To INSTITUTE FOR SYSTEMS BIOLOGY Award HHSN272200800058C
  3. May 30, 2013$10.1M from Defense Threat Reduction Agency: Igf::ot::igf pre-symptomatic detection of post-operative sepsis-base period20 To INSTITUTE FOR SYSTEMS BIOLOGY Award HDTRA113C0055
  4. Sep 29, 2014$9.7M from National Institutes of Health: Igf::ot::igf cancer genomics cloud21 To INSTITUTE FOR SYSTEMS BIOLOGY Award HHSN261201400007C
  5. Jun 15, 2008$6.5M from Defense Threat Reduction Agency: Base period22 To INSTITUTE FOR SYSTEMS BIOLOGY Award HDTRA108C0023

PPP loans

Paycheck Protection Program loans of $150,000 and up, approved April 2020 to July 2021, from the SBA23. Matched to this company by name and state.

  1. Apr 13, 2020$3.0M PPP loan (first draw) from KeyBank National Association23To INSTITUTE FOR SYSTEMS BIOLOGY, Seattle WA; $3.0M forgiven Aug 30, 2021

Sources

The numbers on this page point here. Each one links to the record it came from.

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