KRRO on Nasdaq

Korro Bio, Inc.

In its 2026 annual report the company says: “We are a biopharmaceutical company with a mission to discover, develop and commercialize a new class of genetic medicines based on editing RNA, enabling the treatment of both rare and highly prevalent diseases. We are generating a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process to effect a precise yet transient change to a single nucleoside (adenosine to an inosine edit).”3 It is headquartered in Cambridge, Massachusetts.1 Its shares trade on Nasdaq under the symbol KRRO.1

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Last updated Oct 21, 2026.

Overview

Compare with KYNTRA BIO, INC., Heat Biologics or Immunome Inc., or pick any stock.

  • TickerKRRO on Nasdaq1
  • IndustryPharmaceutical Preparations1
  • HeadquartersCambridge, Massachusetts1
  • Incorporated inDE2
  • Business address60 First Street, 2Nd Floor, Suite 250, Cambridge, Ma 021412
  • Filer categoryNon-accelerated filer, Smaller reporting company2

We are a biopharmaceutical company with a mission to discover, develop and commercialize a new class of genetic medicines based on editing RNA, enabling the treatment of both rare and highly prevalent diseases. We are generating a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process to effect a precise yet transient change to a single nucleoside (adenosine to an inosine edit). By editing RNA instead of DNA, we are expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. We use an oligonucleotide-based approach and expect to bring our medicines to patients by leveraging our proprietary platform with precedented delivery modalities, including N-acetylgalactosamine, or GalNAc, -conjugated delivery for subcutaneous admin…3 From its latest annual report

Financials

From the company’s reports to the SEC. Every number links to the filing it came from.

Key numbers, fiscal 2025

-1906.4%Operating margin4
-1834.5%Net margin4
181.5%Revenue growth, 20254
-228.0%Return on equity4
-$79.1MFree cash flow4

Where the money goes

Where each dollar of revenue went, fiscal 2025

  • Research and development99¢$65.6M
  • Income tax1¢$637.0K

Out of $6.4M in revenue.4 The company lost money this year.

Financial statements

Revenue56784$6.4M in 2025−78% since 2019
0$10.0M$20.0M$30.0M$40.0M2019: $28.9M$28.9M20192020: $37.0M$37.0M2020+28%2021: $14.1M$14.1M2021−62%2022: $0$020222023: $0$020232024: $2.3M$2.3M20242025: $6.4M$6.4M2025+181%
Operating income567984-$121.9M in 2025+489% since 2019
-$150.0M-$100.0M-$50.0M02019: -$20.7M-$20.7M20192020: -$27.6M-$27.6M2020+33%2021: -$84.0M-$84.0M2021+205%2022: -$59.0M-$59.0M2022−30%2023: -$84.5M-$84.5M2023+43%2024: -$91.9M-$91.9M2024+9%2025: -$121.9M-$121.9M2025+33%
Net income567984-$117.3M in 2025+526% since 2019
-$150.0M-$100.0M-$50.0M02019: -$18.7M-$18.7M20192020: -$26.5M-$26.5M2020+41%2021: -$84.7M-$84.7M2021+219%2022: -$58.0M-$58.0M2022−31%2023: -$81.2M-$81.2M2023+40%2024: -$83.6M-$83.6M2024+3%2025: -$117.3M-$117.3M2025+40%

Every line of the income statement as filed: the last 2 fiscal years, latest first.4

Period ending2025-12-312024-12-31
Collaboration revenue$6.4M$2.3M
Research and development$65.6M$63.6M
General and administrative$28.2M$30.5M
Long-lived asset impairment charge$30.9M$0
Restructuring charge$3.6M$0
Total operating expenses$128.2M$94.2M
Loss from operations-$121.9M-$91.9M
Other income, net$5.2M$8.5M
Total other income, net$5.2M$8.5M
Loss before provision for income taxes-$116.6M-$83.4M
Provision for income taxes-$637.0K-$141.0K
Net loss-$117.3M-$83.6M
Unrealized (loss) gain on available-for-sale marketable securities-$26.0K$184.0K
Foreign currency translation adjustments, net-$30.0K$84.0K
Comprehensive loss-$117.3M-$83.3M
Net loss per share, basic-$12.48-$9.37
Net loss per share, diluted-$12.48-$9.37
Weighted-average shares used in computing net loss per share, basic9.4M shares8.9M shares
Weighted-average shares used in computing net loss per share, diluted9.4M shares8.9M shares

Compare Korro Bio, Inc. with another company

Corporate structure

Korro Bio, Inc. sits at the top of its group. 1 entity, 1 country on record. Switch between the flow chart and the network, and select any entity to see its details.

Major holders of Korro Bio, Inc.

  • Korro Bio, Inc. Cambridge, Massachusetts

Built from major holders from Schedules 13D and 13G. Each entity in the chart links to its source.

What it owns

What Korro Bio, Inc. reports owning in its annual reports to the SEC: buildings, land and equipment, real estate and locations, investments, intangible assets and inventory, at the end of its latest fiscal year and a year before.

Property and equipment

ItemLatestA year beforeChange
Property and equipment, before depreciation$18.7M4 Dec 31, 2025$35.0M4 Dec 31, 2024−46.5%
Accumulated depreciation$10.6M4 Dec 31, 2025$7.3M4 Dec 31, 2024+44.2%
Property and equipment, net$8.2M4 Dec 31, 2025$27.7M4 Dec 31, 2024−70.5%
Operating-lease assets (leased space)$8.1M4 Dec 31, 2025$23.8M4 Dec 31, 2024−66.2%

Investments

ItemLatestA year beforeChange
Cash and cash equivalents$21.8M4 Dec 31, 2025$55.6M4 Dec 31, 2024−60.8%
Marketable securities, current$53.3M4 Dec 31, 2025$70.5M4 Dec 31, 2024−24.3%
Marketable securities, non-current$10.0M4 Dec 31, 2025$37.0M4 Dec 31, 2024−72.9%
Debt securities available for sale$63.4M4 Dec 31, 2025$107.4M4 Dec 31, 2024−41.0%

Properties, in its own words

Our principal office is located at 60 First Street, 2nd Floor, Suite 250, Cambridge, MA 02141, where we lease approximately 50,453 square feet of office and laboratory space. The lease term began in May 2023 and will end in April 2034 with an option to extend the term of the lease for an additional five years.

We believe that our existing office and laboratory space is adequate for our needs for the foreseeable future. If required, we believe that suitable additional or substitute space will be available in the future on commercially reasonable terms to accommodate any such expansion of our operations.

Item 2 of the 10-K filed Mar 12, 2026.3

Leadership

Who has led Korro Bio, Inc., and when. Pick a name to see everywhere that person has worked.

Board members and other officers (27)

Former names

  • Frequency Therapeutics, Inc.Apr 14, 2017 to Nov 6, 20232

Timeline

  1. Oct 5, 20268-K Other events42
  2. Aug 19, 20268-K Other events43
  3. Aug 6, 20268-K Entered a material agreement; Results of operations; Unregistered sale of shares44
  4. Jun 11, 20268-K Shareholder vote45
  5. May 19, 20268-K Other events46
  6. May 7, 20268-K Results of operations47
  7. Mar 12, 20268-K Results of operations48
  8. Mar 9, 20268-K Entered a material agreement; Results of operations; Unregistered sale of shares49
  9. Jan 27, 20268-K Other events50
  10. Jan 15, 20268-K Other events51
  11. Dec 18, 20258-K Executive or director change52
  12. Nov 12, 20258-K Entered a material agreement; Results of operations; Exit or restructuring costs53
  13. Nov 7, 2023New chief executive Ram Aiyar becomes CEO12
  14. Oct 2, 2019New chief executive David L. Lucchino becomes CEO13

Calendar

Coming up

  1. Nov 11, 2026Reports results for the quarter ending Sep/2026 A year earlier it reported ($1.92) a share, on Nov 12, 2025.54

When it reported results

  1. Aug 6, 2026Reported quarterly or annual results44
  2. May 7, 2026Reported quarterly or annual results47
  3. Mar 12, 2026Reported quarterly or annual results48
  4. Mar 9, 2026Reported quarterly or annual results49
  5. Nov 12, 2025Reported quarterly or annual results53
  6. Aug 12, 2025Reported quarterly or annual results55
  7. May 7, 2025Reported quarterly or annual results56
  8. Mar 18, 2025Reported quarterly or annual results57

Upcoming dates from Nasdaq's calendar; past results from the company's 8-K filings (Item 2.02). The full markets calendar

Filings

615 filings to the SEC since October 2021: 6 annual reports, 15 quarterly reports, 68 major events, 219 insider forms, 49 large holders, 258 other. The latest 20:

  1. Oct 5, 20268-K EDGAR
  2. Sep 15, 20264 EDGAR
  3. Sep 14, 2026144 EDGAR
  4. Sep 14, 2026144 EDGAR
  5. Sep 14, 20264 EDGAR
  6. Sep 11, 2026144 EDGAR
  7. Sep 11, 2026144 EDGAR
  8. Sep 11, 2026144 EDGAR
  9. Sep 10, 20264 EDGAR
  10. Sep 9, 2026144 EDGAR
  11. Sep 8, 2026144 EDGAR
  12. Aug 28, 20264 EDGAR
  13. Aug 26, 2026144 EDGAR
  14. Aug 26, 2026144 EDGAR
  15. Aug 21, 20264 EDGAR
  16. Aug 19, 2026144 EDGAR
  17. Aug 19, 2026144 EDGAR
  18. Aug 19, 20268-K EDGAR
  19. Aug 14, 2026SCHEDULE 13G/A EDGAR
  20. Aug 13, 20264 EDGAR

The 615 filings since October 2021 can be filtered by form type and year here when JavaScript is on.

Every filing from the last five years, summarized. The full record is on SEC EDGAR.

Insider trades

168 open-market trades by officers, directors and large owners since October 2021: 22 buys and 146 sales. Grants, option exercises and gifts are left out.

DateWhoTradeSharesPriceValueFiling
Sep 14, 2026FORMELA JEAN FRANCOISDirectorSale38,490$14.12$543.5KForm 4
Sep 11, 2026Dolan OliverSenior Vice President, FinanceSale5$13.72$69Form 4
Sep 11, 2026FORMELA JEAN FRANCOISDirectorSale10,200$13.99$142.7KForm 4
Sep 9, 2026Dolan OliverSenior Vice President, FinanceSale6$13.60$82Form 4
Sep 8, 2026Dolan OliverSenior Vice President, FinanceSale7,347$13.51$99.3KForm 4
Aug 26, 2026FORMELA JEAN FRANCOISDirectorSale300$13.96$4.2KForm 4
Aug 19, 2026FORMELA JEAN FRANCOISDirectorSale28,468$14.00$398.6KForm 4
Aug 11, 2026FORMELA JEAN FRANCOISDirectorSale2,143$13.96$29.9KForm 4
Aug 10, 2026Lynx1 Capital Management LP10% ownerBuy1,462$13.19$19.3KForm 4
Aug 6, 2026Lynx1 Capital Management LP10% ownerBuy5,222$11.40$59.5KForm 4
Aug 4, 2026Aiyar RamPresident and CEOSale5,802$10.84$62.9KForm 4
Jul 6, 2026FORMELA JEAN FRANCOISDirectorSale9,323$13.96$130.1KForm 4
Jul 2, 2026FORMELA JEAN FRANCOISDirectorSale100,700$14.03$1.4MForm 4
Jun 24, 2026FORMELA JEAN FRANCOISDirectorSale48,438$14.61$707.5KForm 4
Jun 23, 2026FORMELA JEAN FRANCOISDirectorSale119,005$14.25$1.7MForm 4
Jun 22, 2026FORMELA JEAN FRANCOISDirectorSale3,962$13.95$55.3KForm 4
Jun 16, 2026Chappell ToddChief Operating OfficerSale3,168$10.83$34.3KForm 4
Jun 16, 2026Vincent Loic AChief Scientific OfficerSale3,418$10.83$37.0KForm 4
Jun 16, 2026Cerio JeffreyGeneral CounselSale6,609$10.83$71.6KForm 4
Jun 16, 2026Dolan OliverSenior Vice President, FinanceSale3,383$10.83$36.6KForm 4

All 168 trades can be filtered by person here when JavaScript is on.

From Forms 4 filed with the SEC.

Major holders

Investors who own more than 5% of the shares must tell the SEC: a 13D if they may seek to influence the company, a 13G if they hold passively.

Executive pay

What the company paid its top executives, from the summary compensation table in its proxy statement. Total pay includes salary, bonus, stock and option awards and other pay, as the company valued them.

YearExecutiveAgeSalaryTotal pay
2025Ram Aiyar$633.2K$3.1M80
2025Kemi Olugemo$424.7K$2.3M80
2025Vineet Agarwal$375.3K$1.7M80
2025Jeffrey Cerio$425.0K$1.6M80
2025Chief Scientific Officer$361.8K$1.6M80
2024Former Chief Medical Officer$292.7K$2.7M80
2024Senior Vice PresidentGeneral Counsel and Corporate Secretary$138.2K$1.5M80
2024Chief Executive OfficerPresident and Interim Chief Financial Officer$610.0K$939.1K80
2024Former Chief Financial Officer$440.0K$617.5K80

Held by these funds

The largest holders among investment managers' 13F reports for the quarter ending Jun 30, 2026, the top 25 of 100. Change is in shares since the quarter before.

FundSharesValueShare of the fundChange
Lynx1 Capital Management LP1,538,296$20.3M2.3%No change
Nantahala Capital Management, LLC1,320,072$17.4M0.5%+660,036
NEA Management Company, LLC1,297,893$17.1M1.1%No change
Venrock Adviser, LLC1,009,500$13.3M0.4%No change
Atlas Venture Life Science Advisors, LLC962,884$12.7M1.4%−174,265
Balyasny Asset Management L.P.951,783$12.5M0.0%−88,271
BlackRock, Inc.817,621$10.8M0.0%+357,615
Affinity Asset Advisors, LLC706,904$9.3M0.5%No change
Adage Capital Partners Gp, L.l.c.540,968$7.1M0.0%+312,568
ADAR1 Capital Management, LLC540,054$7.1M0.3%No change
Vanguard Capital Management LLC454,778$6.0M0.0%+143,865
Driehaus Capital Management LLC450,045$5.9M0.0%No change
TCG Crossover Management, LLC416,301$5.5M0.1%No change
Kalehua Capital Management LLC405,040$5.3M1.7%+295,664
Siren, L.L.C.347,718$4.6M0.1%No change
Aqr Capital Management LLC298,974$3.9M0.0%+31,219
Geode Capital Management, LLC296,870$3.9M0.0%+123,227
72 Investment Holdings, LLC276,831$3.6M7.3%No change
State Street Corp232,587$3.1M0.0%+92,246
Vanguard Portfolio Management LLC223,551$2.9M0.0%+74,992
Two Sigma Investments, LP178,071$2.3M0.0%+12,599
Jpmorgan Chase & Co124,726$1.6M0.0%+56,226
Millennium Management LLC118,434$1.6M0.0%+54,828
Goldman Sachs Group Inc116,983$1.5M0.0%+66,442
Renaissance Technologies LLC110,524$1.5M0.0%−25,703

13F reports cover disclosed long positions in U.S. stocks only.

SEC filer profile

How Korro Bio, Inc. is registered with the Securities and Exchange Commission, from its EDGAR record and the cover page of its latest annual report.

  • Name on EDGARKorro Bio, Inc.1
  • CIK0001703647
  • Employer ID (EIN)47-23244503
  • Filer statusNon-accelerated filer not an emerging growth company; a smaller reporting company; not a shell company3
  • Incorporated inDelaware3
  • Fiscal year endsDecember 311
  • Industry code (SIC)2834 Pharmaceutical Preparations1
  • SEC reviewing officeOffice of Life Sciences, Division of Corporation Finance1
  • Business address60 First Street, 2Nd Floor, Suite 250, Cambridge, MA 021411
  • Phone617-468-19991
  • Shares outstanding14,725,646 as of Aug 5, 202611
  • Public float$89.0M as of Jun 30, 20253
  • AuditorErnst & Young LLP, Boston, Massachusetts PCAOB ID 42; no auditor attestation of internal control over financial reporting3
  • On EDGAR sinceApr 14, 20171
  • Filings825 in all: 4 (297), 144 (166), 8-K (92), 3 (46), 424B3 (27), 10-Q (21), SC 13G/A (19), SC 13G (16)1
    All 43 form types

    CORRESP (15), SCHEDULE 13G/A (12), EFFECT (11), UPLOAD (11), SCHEDULE 13G (8), 10-K (7), 4/A (7), DEFA14A (7), 425 (6), DEF 14A (6), S-8 (6), S-3 (4), 424B5 (3), ARS (3), D (3), POS AM (3), S-1 (3), S-1/A (3), S-4/A (3), 5 (2), SC 13D (2), SCHEDULE 13D/A (2), SEC STAFF LETTER (2), 10-K/A (1), 144/A (1), 424B4 (1), 8-A12B (1), 8-K/A (1), CERT (1), DRS (1), DRS/A (1), DRSLTR (1), PRE 14A (1), S-4 (1), SC 13D/A (1)

  • Latest filingsAnnual report (10-K) Mar 12, 2026
    Quarterly report (10-Q) Aug 6, 2026
    Proxy statement (DEF 14A) Apr 16, 2026
    Latest 8-K (8-K) Oct 5, 2026

Securities registered for trading

ClassSymbolExchange
Common stock, par value $0.001 per shareKRRONasdaq

From the cover page of the 10-K filed Mar 12, 2026 (Section 12(b) of the Exchange Act).3

Risk factors and legal proceedings

The risks Korro Bio, Inc. names in Item 1A of its 10-K filed Mar 12, 2026: 73 risks under these headings, as written.3

  • Risks Related to Our Business
  • We have incurred significant losses since inception. We expect to incur losses for the foreseeable future and may never achieve or maintain profitability.
  • We have never generated revenue from product sales and may never become profitable.
  • We will need substantial additional funding. If we are unable to raise capital when needed, we will be forced to delay, reduce, eliminate or prioritize among our research and development programs or future commercialization efforts.
  • We did not reach projected levels of protein in patients in our Phase 1/2a REWRITE clinical trial of KRRO-110 for AATD and have transitioned to GalNAc-conjugated delivery for our AATD program, and may experience delays in developing a potential treatment for AATD. We have not completed any clinical trials nor reported any clinical trial results for any of our proposed delivery methods or RNA editing approaches. Any favorable results we may have from our earlier preclinical studies may not be predictive of results that may be observed in later preclinical studies or clinical trials.
  • If preclinical studies or clinical trials of any lead candidate or development candidate we may identify fail to demonstrate safety and efficacy to the satisfaction of regulatory authorities or do not otherwise produce positive results, we may incur additional costs or experience delays in completing, or ultimately be unable to complete, the development and commercialization of such development candidate.
  • Our business is substantially dependent on the success of KRRO-121, our lead development candidate, and if KRRO-121 fails to advance successfully, our business would be materially and adversely affected.
  • If we experience delays or difficulties in the enrollment of patients in clinical trials, or other delays in our clinical trials, our receipt of necessary regulatory approvals could be delayed or prevented.
  • Risks Related to Discovery, Development and Commercialization
  • The gene editing field and RNA editing in particular is relatively new and is evolving rapidly. We are very early in our development efforts and may not be successful in identifying and developing any candidates. It will be many years before we or our collaborators commercialize a development candidate or generate any revenues, if ever. Additionally, other genetic medicine technologies may be discovered that provide significant advantages over RNA editing, which could materially harm our business.
  • RNA editing is a novel technology with limited clinical validation for human therapeutic use. The approaches we take to discover and develop novel therapeutics are unproven and may never lead to marketable products.
  • We are very early in our development efforts, and our preclinical studies and clinical trials may not be successful. If we are unable to commercialize our development candidates or experience significant delays in doing so, our business will be materially harmed.
The other 63 risks
  • Any development candidates we develop may fail in preclinical or clinical development or be delayed to a point where they do not become commercially viable.
  • We may not be able to conduct clinical trials successfully due to various process-related factors that could negatively impact our business plans.
  • If we cannot successfully manufacture our development candidates for our research and development and preclinical activities, or manufacture sufficient amounts of our development candidates to meet our clinical requirements and timelines, our business may be materially harmed.
  • The process of manufacturing oligonucleotides is complex and we may encounter difficulties in production, particularly with respect to process development or scaling-up of our manufacturing capabilities.
  • We may expend our limited resources to pursue a particular development candidate or indication and fail to capitalize on development candidates or indications that may be more profitable or for which there is a greater likelihood of success.
  • Our development candidates may cause undesirable and unforeseen side effects or be perceived by the public as unsafe, which could delay or prevent their advancement into clinical trials or regulatory approval, limit the commercial potential or result in significant negative consequences.
  • If we are unable to successfully identify patients who are likely to benefit from therapy with any development candidates we develop, or experience significant delays in doing so, we may not realize the full commercial potential of any products we may develop.
  • If we are unable to establish sales and marketing capabilities or enter into agreements with third parties to market and sell any development candidates, we may be unable to generate any revenues.
  • Even if we receive regulatory approval to market our development candidates, the market may not be receptive to our development candidates upon their commercial introduction, which will prevent us from becoming profitable.
  • The pharmaceutical industry is intensely competitive. If we are unable to compete effectively with existing drugs, new treatment methods and new technologies, we may be unable to commercialize successfully any drugs that we develop.
  • Healthcare legislative or regulatory reform measures may have a negative impact on our business and results of operations.
  • If the market opportunities for any development candidates we may develop are smaller than we believe they are, our potential revenues may be adversely affected, and our business may suffer.
  • While we intend to seek designations for our development candidates with the FDA and comparable foreign regulatory authorities that are intended to confer benefits such as a faster development process or an accelerated regulatory pathway, there can be no assurance that we will successfully obtain such designations. In addition, even if one or more of our development candidates are granted such designations, we may not be able to realize the intended benefits of such designations.
  • Risks Related to Regulatory, Legal, and Clinical Trials
  • Because we are developing oligonucleotides, which are considered a relatively new class of drugs, there is increased risk that the outcome of our clinical trials will not be sufficient to obtain regulatory approval.
  • Because we are developing development candidates in the field of genetic medicines in which there is little clinical experience, there is increased risk that the FDA, the EMA, HREC, TGA or other regulatory authorities may not consider the endpoints of our clinical trials to provide clinically meaningful results and that these results may be difficult to analyze.
  • Even if we complete the necessary preclinical studies and clinical trials, we cannot predict when, or if, we will obtain regulatory approval to commercialize a development candidate and the approval may be for a narrower indication than we seek.
  • We may be unable to obtain regulatory approval in the United States or foreign jurisdictions and, as a result, be unable to commercialize our development candidates and our ability to generate revenue will be materially impaired.
  • Any development candidates for which we obtain marketing approval will be subject to extensive post-marketing regulatory requirements and could be subject to post-marketing restrictions or withdrawal from the market, and we may be subject to penalties if we fail to comply with regulatory requirements or if we experience unanticipated problems with our development candidates, when and if any of them are approved.
  • Even if we obtain regulatory approvals, our marketed drugs will be subject to ongoing regulatory oversight. If we fail to comply with continuing U.S. and foreign requirements, our approvals, if obtained, could be limited or withdrawn, we could be subject to other penalties, and our business would be seriously harmed.
  • The insurance coverage and reimbursement status of newly-approved products is uncertain. Failure to obtain or maintain adequate coverage and reimbursement for our development candidates could limit our product revenues.
  • We may not be able to obtain orphan drug exclusivity for one or more of our development candidates, and even if we do, that exclusivity may not prevent the FDA or the EMA from approving other competing products.
  • If we do not comply with laws regulating the protection of the environment and health and human safety, our business could be adversely affected.
  • If we or our collaborators, manufacturers, service providers or other third parties fail to comply with applicable healthcare laws and regulations, we could be subject to enforcement actions, which could affect our ability to develop, market and sell our products and may harm our reputation.
  • Our employees, consultants and collaborators may engage in misconduct or other improper activities, including noncompliance with regulatory standards and requirements.
  • Product liability lawsuits against us could cause us to incur substantial liabilities and could limit commercialization of any medicines that we may develop.
  • Our internal computer and information systems, or those used by our CROs, CMOs or other contractors or consultants, may fail or suffer security breaches, which could result in a material disruption of our development programs.
  • We may be unable to adequately protect our information systems from cybersecurity incidents or data breaches, which could result in the disclosure of confidential information, damage our reputation, and subject us to significant financial and legal exposure.
  • Our failure to obtain regulatory approval in international jurisdictions would prevent us from marketing our development candidates outside the United States.
  • Disruptions at the FDA, SEC and other government agencies caused by staffing cuts, funding shortages or global health concerns could hinder their ability to hire, retain or deploy key leadership and other personnel, or otherwise prevent new or modified products from being developed, approved, or commercialized in a timely manner or at all, which could negatively impact our business.
  • We, our collaborators and our service providers may be subject to a variety of privacy and data security laws, regulations and contractual obligations, and our failure to comply with them could harm our business.
  • The use of new and evolving technologies, such as artificial intelligence, or AI, in our offerings may result in spending material resources and presents risks and challenges that can impact our business including by posing security and other risks to our confidential information, proprietary information and personal information, and as a result we may be exposed to reputational harm and liability.
  • Risks Related to Our Third Party Relationships
  • We may be subject to claims that we or our employees or consultants have wrongfully used or disclosed alleged trade secrets of employees’ or consultants’ former employers or their clients. These claims may be costly to defend and if we do not successfully do so, we may be required to pay monetary damages and may lose valuable intellectual property rights or personnel.
  • We expect to rely on third parties to conduct our clinical trials and some aspects of our research, as well as some aspects of our delivery methods, and those third parties may not perform satisfactorily, including failing to meet deadlines for the completion of such trials, research or testing.
  • We may not be successful in finding strategic collaborators for continuing development of certain of our development candidates or successfully commercializing or competing in the market for certain indications; and we may not see any benefit from our collaboration agreement with Novo Nordisk, which is currently on hold.
  • Future acquisitions or strategic alliances could disrupt our business and harm our financial condition and results of operations.
  • We rely, and anticipate that we will rely, on third parties to design, conduct, supervise and monitor our preclinical studies and clinical trials, and if those third parties perform in an unsatisfactory manner, it may harm our business.
  • We rely on third parties in the supply and manufacture of our lead candidates and development candidates for our research, preclinical and clinical activities, and may do the same for commercial supplies of our lead or development candidates.
  • Risks Related to Our Personnel, Operations and Growth
  • If we are unable to attract and retain qualified key management and scientists, staff, consultants and advisors, our ability to implement our business plan may be adversely affected.
  • We expect to need to expand our research, development, delivery, manufacturing, commercialization, regulatory and future sales and marketing capabilities over time, and as a result, we may encounter difficulties in managing our future growth, which could disrupt our operations.
  • Risks Related to Intellectual Property
  • If we are not able to obtain or protect intellectual property rights related to any of our lead candidates and development candidates, development and commercialization of our development candidates may be adversely affected.
  • Our pending patent applications may not issue as patents, and even issued patents may not provide sufficient protection of our RNA editing platform OPERA, our lead candidates and our development candidates.
  • We may not identify relevant third-party patents or may incorrectly interpret the relevance, scope or expiration of a third-party patent, which might adversely affect our ability to develop and market our development candidates.
  • We may be involved in lawsuits to protect or enforce our patents, which could be expensive, time consuming and unsuccessful.
  • Third-party claims of intellectual property infringement may prevent, delay or otherwise interfere with our product discovery and development efforts.
  • We may not be successful in acquiring or in-licensing necessary rights to key technologies or any development candidates we may develop.
  • We may become subject to claims challenging the inventorship or ownership of our patents and other intellectual property.
  • Third parties may assert that our employees, consultants, or advisors have wrongfully used or disclosed confidential information or misappropriated trade secrets.
  • Obtaining and maintaining our patent protection depends on compliance with various procedural, document submission, fee payment, and other requirements imposed by government patent agencies, and our patent protection could be reduced or eliminated for non-compliance with these requirements.
  • We have limited foreign intellectual property rights and may not be able to protect our intellectual property and proprietary rights throughout the world.
  • Changes in patent law in the United States and in non-U.S. jurisdictions could diminish the value of patents in general, thereby impairing our ability to protect our RNA editing platform technology, lead candidates and development candidates.
  • If we are unable to protect the confidentiality of our trade secrets, our business and competitive position would be harmed.
  • Patent terms may be inadequate to protect our competitive position on our development candidates for an adequate amount of time.
  • If we do not obtain PTE and data exclusivity for any development candidates we may develop, our business may be materially harmed.
  • Intellectual property rights do not necessarily address all potential threats.
  • Our use of open source software could impose limitations on our ability to commercialize our development candidates.
  • If our trademarks and trade names are not adequately protected, then we may not be able to build name recognition in our markets of interest and our business may be adversely affected.
  • General Risk Factors
  • Our business could be materially and adversely affected in the future by the effects of disease outbreaks, epidemics and pandemics.
  • Our operations are vulnerable to interruption by disasters, terrorist activity, pandemics and other events beyond our control, which could harm our business.
  • Litigation costs and the outcome of litigation could have a material adverse effect on our business.
  • The price of our common stock is volatile and fluctuates substantially, which could result in substantial losses for our stockholders.
  • We are incurring and expect to continue to incur additional costs and increased demands upon management as a result of complying with the laws and regulations affecting public companies.
  • Once we are no longer a smaller reporting company or otherwise no longer qualify for applicable exemptions, we will be subject to additional laws and regulations affecting public companies that will increase our costs and the demands on management and could harm our operating results and cash flows.
  • If we fail to maintain proper and effective internal controls, our ability to produce accurate financial statements on a timely basis could be impaired.

Legal proceedings

From time to time, we may be involved in various other claims and legal proceedings relating to claims arising out of our operations. We are not currently a party to any material legal proceedings.

The opening of Item 3, Legal Proceedings.3

Sources

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