NKTR on Nasdaq

Nektar Therapeutics

American healthcare company

Nektar Therapeutics is an American biopharmaceutical company. The company was founded in 1990 and is based in San Francisco, California. The company develops new drug candidates by applying its proprietary PEGylation and advanced polymer conjugate technologies to modify chemical structure of substances, which improves drug characteristics like retention and solubility.3 Its shares trade on Nasdaq under the symbol NKTR.1 Wikipedia text CC BY-SA 4.0

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Last updated Oct 21, 2026.

Overview

1990Founded1

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  • TickerNKTR on Nasdaq1
  • IndustryPharmaceutical Preparations1
  • HeadquartersSan Francisco1
  • Websitewww.nektar.com
  • Incorporated inDE5
  • Business address455 Mission Bay Boulevard South, San Francisco, Ca 941585
  • Filer categoryNon-accelerated filer, Smaller reporting company5
  • Legal formCorporation4
  • LEI5299005I24806IOIYE034
  • StatusActive4
  • LEI statusLapsed (not renewed)4
  • Registered addressc/o THE CORPORATION TRUST COMPANY, CORPORATION TRUST CENTER 1209 ORANGE ST, 19801 Wilmington, United States4
  • Registered withDivision of Corporations, Department of State, 29039704

Nektar Therapeutics is an American biopharmaceutical company. The company was founded in 1990 and is based in San Francisco, California. The company develops new drug candidates by applying its proprietary PEGylation and advanced polymer conjugate technologies to modify chemical structure of substances, which improves drug characteristics like retention and solubility. It is a technology supplier to a number of pharmaceutical companies including Affymax, Amgen, Merck, Pfizer and UCB Pharma, etc. The company developed the world's first inhalable non-injectable insulin, Exubera, which was awarded as the bronze award by Wall Street Journal for its technological breakthrough.3

Financials

From the company’s reports to the SEC. Every number links to the filing it came from.

Key numbers, fiscal 2025

-253.7%Operating margin7
-297.1%Net margin7
-43.9%Revenue growth, 20257
-182.6%Return on equity7
-$208.7MFree cash flow7

What sells

Revenue by product, business segment and region, as the company reports it to the SEC.

Products and services

Non Cash Royalty Revenue Related To Sale Of Future Royalties brought in 50% of the revenue Nektar Therapeutics broke down this way in fiscal 2025.

  1. Non Cash Royalty Revenue Related To Sale Of Future Royalties$54.9M750%down 15% from 2024
  2. Non Cash Royalties$54.9M750%down 15% from 2024
  3. License Collaboration And Other Revenue$300.0K70%down 50% from 2024
Products and services by year
Products and services20242025
Non Cash Royalty Revenue Related To Sale Of Future Royalties$64.3M$54.9M
Non Cash Royalties$64.3M$54.9M
License Collaboration And Other Revenue$597.0K$300.0K

Where the money goes

Where each dollar of revenue went, fiscal 2025

  • Research and development100¢$117.3M
  • Income tax0¢$138.0K

Out of $55.2M in revenue.7 The company lost money this year.

Financial statements

Revenue8910117$55.2M in 2025−52% since 2019
0$50.0M$100.0M$150.0M$200.0M2019: $114.6M$114.6M20192020: $152.9M$152.9M2020+33%2021: $101.9M$101.9M2021−33%2022: $92.1M$92.1M2022−10%2023: $90.1M$90.1M2023−2%2024: $98.4M$98.4M2024+9%2025: $55.2M$55.2M2025−44%
Operating income8910117-$140.1M in 2025−68% since 2019
-$600.0M-$400.0M-$200.0M02019: -$440.0M-$440.0M20192020: -$425.1M-$425.1M2020−3%2021: -$446.1M-$446.1M2021+5%2022: -$376.2M-$376.2M2022−16%2023: -$263.7M-$263.7M2023−30%2024: -$105.2M-$105.2M2024−60%2025: -$140.1M-$140.1M2025+33%
Net income8910117-$164.1M in 2025−63% since 2019
-$600.0M-$400.0M-$200.0M02019: -$440.7M-$440.7M20192020: -$444.4M-$444.4M2020+1%2021: -$523.8M-$523.8M2021+18%2022: -$368.2M-$368.2M2022−30%2023: -$276.1M-$276.1M2023−25%2024: -$119.0M-$119.0M2024−57%2025: -$164.1M-$164.1M2025+38%

Every line of the income statement as filed: the last 2 fiscal years, latest first.7

Period ending2025-12-312024-12-31
Total revenue$55.2M$98.4M
Cost of goods sold$0$30.7M
General and administrative$68.7M$76.8M
Restructuring and impairment$9.3M$15.7M
Gain on sale of the Huntsville manufacturing facility$0-$40.4M
Total operating costs and expenses$195.3M$203.6M
Loss from operations-$140.1M-$105.2M
Non-cash interest expense on liabilities related to the sales of future royalties-$26.2M-$28.1M
Interest income$10.4M$14.5M
Total non-operating income (expense), net-$15.4M-$14.0M
Loss before benefit for income taxes and equity method investment-$155.5M-$119.2M
Benefit for income taxes-$138.0K-$239.0K
Loss before equity method investment-$155.3M-$119.0M
Loss from equity method investment-$8.7M$0
Net loss-$164.1M-$119.0M
Basic net loss per share (in dollars per share)-$9.73-$8.68
Diluted net loss per share (in dollars per share)-$9.73-$8.68
Weighted average shares outstanding used in computing basic net loss per share (in shares)16.9M shares13.7M shares
Weighted average shares outstanding used in computing diluted net loss per share (in shares)16.9M shares13.7M shares
Research and development$117.3M$120.9M
Other income (expense), net$361.0K-$390.0K
Reverse stock split, ratio0 pure

Compare Nektar Therapeutics with another company

Corporate structure

Nektar Therapeutics sits at the top of its group. 2 entities, 2 countries on record. Switch between the flow chart and the network, and select any entity to see its details.

Major holders of Nektar Therapeutics

  • Two Seas Capital LP Filed SCHEDULE 13G/A on Nektar Therapeutics, latest Sep 28, 2026 (3 filings since Apr 17, 2026)
  • BIOTECHNOLOGY VALUE FUND L P Filed SCHEDULE 13G/A on Nektar Therapeutics, latest Aug 14, 2026 (3 filings since Jul 9, 2025)
  • VANGUARD CAPITAL MANAGEMENT LLC Filed SCHEDULE 13G on Nektar Therapeutics, latest Jul 31, 2026
  • BlackRock Filed SCHEDULE 13G on Nektar Therapeutics, latest Jul 29, 2026 (10 filings since Jan 26, 2022)
  • FMR LLC Filed SCHEDULE 13G/A on Nektar Therapeutics, latest May 6, 2026 (4 filings since Dec 10, 2021)
  • VANGUARD GROUP INC Filed SCHEDULE 13G/A on Nektar Therapeutics, latest Mar 27, 2026 (7 filings since Jan 10, 2022)
  • SUSQUEHANNA SECURITIES, LLC Filed SCHEDULE 13G/A on Nektar Therapeutics, latest Feb 13, 2026 (2 filings since Nov 13, 2025)
  • Nantahala Capital Management, LLC Filed SCHEDULE 13G/A on Nektar Therapeutics, latest Nov 14, 2025 (2 filings since Aug 14, 2025)
  • TCG Crossover GP II, LLC Filed SCHEDULE 13G/A on Nektar Therapeutics, latest Nov 14, 2025 (3 filings since Mar 15, 2024)
  • INTEGRATED CORE STRATEGIES (US) LLC Filed SCHEDULE 13G/A on Nektar Therapeutics, latest Oct 28, 2025 (2 filings since Jul 3, 2025)
  • SAMLYN CAPITAL, LLC Filed SCHEDULE 13G/A on Nektar Therapeutics, latest May 15, 2025 (2 filings since Feb 14, 2025)
  • Deep Track Capital, LP Filed SCHEDULE 13G/A on Nektar Therapeutics, latest Feb 14, 2025 (4 filings since Apr 14, 2023)
  • Nektar Therapeutics San Francisco, California, United States
    • NEKTAR THERAPEUTICS (INDIA) PRIVATE LIMITED Subsidiary · Hyderabad, India

Built from parent and subsidiary links from GLEIF, the Global Legal Entity Identifier Foundation (CC0); major holders from Schedules 13D and 13G. Each entity in the chart links to its source.

What it owns

What Nektar Therapeutics reports owning in its annual reports to the SEC: buildings, land and equipment, real estate and locations, investments, intangible assets and inventory, at the end of its latest fiscal year and a year before.

Property and equipment

ItemLatestA year beforeChange
Construction in progress$245.0K11 Dec 31, 2024$739.0K11 Dec 31, 2023−66.8%
Accumulated depreciation$15.9M11 Dec 31, 2024$86.9M11 Dec 31, 2023−81.7%
Property and equipment, net$2.1M7 Dec 31, 2025$3.4M7 Dec 31, 2024−39.6%
Operating-lease assets (leased space)$2.9M7 Dec 31, 2025$8.4M7 Dec 31, 2024−65.0%

Investments

ItemLatestA year beforeChange
Cash and cash equivalents$15.1M7 Dec 31, 2025$44.3M7 Dec 31, 2024−65.8%
Marketable securities, current$230.6M7 Dec 31, 2025$211.0M7 Dec 31, 2024+9.3%
Marketable securities, non-current$07 Dec 31, 2025$13.9M7 Dec 31, 2024−100.0%
Debt securities available for sale$216.5M7 Dec 31, 2025$229.3M7 Dec 31, 2024−5.6%
Stakes in other companies (equity method)$3.5M7 Dec 31, 2025$12.2M7 Dec 31, 2024−71.4%

Inventory

ItemLatestA year beforeChange
Inventory, total$07 Dec 31, 2025$07 Dec 31, 2024
Raw materials$011 Dec 31, 2024$1.9M11 Dec 31, 2023−100.0%
Work in process$011 Dec 31, 2024$12.9M11 Dec 31, 2023−100.0%
Finished goods$011 Dec 31, 2024$1.4M11 Dec 31, 2023−100.0%

Properties, in its own words

California

We lease a 155,215 square foot facility in the Mission Bay Area of San Francisco, California (Mission Bay Facility), under an operating lease which expires in January 2030. The Mission Bay Facility is our corporate headquarters. We also lease 135,936 square feet of office space in San Francisco (the Third Street Facility), under an operating lease which expires in January 2030.

The rest of Item 2

In connection with our 2022 and 2023 Restructuring Plans, we have consolidated our San Francisco operations in our Mission Bay Facility, and we have vacated our Third Street Facility and certain laboratory and office spaces at our Mission Bay Facility. We have sublet approximately 29,000 square feet of office and laboratory space in our Mission Bay Facility and are seeking to sublease all of the remaining spaces in both Facilities.

Alabama

We previously owned facilities consisting of approximately 124,000 square feet in Huntsville, Alabama, which housed laboratories as well as administrative, clinical and commercial manufacturing facilities for our PEGylation and advanced polymer conjugate technology operations as well as manufacturing of APIs for early clinical studies. These facilities were sold to Gannet BioChem, an affiliate of Ampersand Management LLC d/b/a Ampersand Capital Partners via the Asset Purchase Agreement on December 2, 2024.

Item 2 of the 10-K filed Mar 13, 2026.15

The story

The company is engaged in developing a proprietary pipeline of drug candidates for several therapeutic areas including oncology, pain, anti-infectives, anti-viral and immunology. The company's research and development involve in small molecule and biologic drug candidates. Its drug candidate base consists of naloxegol (Movantik), a Phase III oral opioid antagonist, etirinotecan pegol, a topoisomerase inhibitor under Phase III clinical study as of 2012, NKTR 061, NKTR-181, NKTR-214, etc.

In 2013, the company was assigned a patent which was developed by the company and other four co-inventors. The products of the company is served as a supplement to improve the pharmacokinetics, pharmacodynamics, half-life, bioavailability and other areas of drugs for the patients worldwide. As of March 2014, the company had a market capitalization of $1.7 billion with an enterprise value of $1.67 billion.

As of December 2024, at a stock price-per-share of roughly $1, the market cap is roughly $171 million. Nektar underwent periods of downsizing after unsuccessful partnerships were ended with Eli Lilly in 2023 and Bristol Myers Squibb in 2022, resulting in layoffs of most company employees.

Pipeline

Etirinotecan pegol was in the phase III BEACON trial as well as in the I-SPY2 adaptive clinical trial for breast cancer in 2016. The European Medicines Agency refused a marketing authorisation in 2017.

Bempegaldesleukin (NKTR-214) is a CD122-biased immune-stimulatory cytokine, Phase I results were announced in November 2016. It is now in a phase 2 trial in combination with nivolumab for various advanced cancers.

In 2023 Nektar's partnership with Eli Lilly in development of "rezpeg" was ended. Eli Lilly claimed the drug lacked suitable efficacy, while Nektar responded that Eli Lilly had botched the analysis.

From Wikipedia’s article on Nektar Therapeutics, shared under CC BY-SA 4.0.6

Leadership

Who has led Nektar Therapeutics, and when. Pick a name to see everywhere that person has worked.

Board members and other officers (29)

Named in SEC Form D filings

People the company listed in its private-offering notices.

  • Executive OfficerMark A Wilson named Mar 19, 202456
  • DirectorR. Scott M Greer named Mar 19, 202456

Products and brands

  • Inhalable insulin

Listed on Wikidata.1

Former names

  • INHALE THERAPEUTIC SYSTEMS INCOct 15, 1998 to Jan 10, 20035
  • INHALE THERAPEUTIC SYSTEMSJul 11, 1996 to May 14, 19985

Timeline

  1. Oct 1, 20268-K Regulation FD disclosure57
  2. Sep 25, 20268-K Other events58
  3. Sep 8, 20268-K Regulation FD disclosure59
  4. Aug 13, 20268-K Results of operations60
  5. Jun 5, 20268-K Shareholder vote61
  6. May 8, 20268-K Entered a material agreement; Executive or director change62
  7. May 7, 20268-K Results of operations63
  8. Apr 23, 20268-K Entered a material agreement; Other events64
  9. Apr 20, 20268-K Regulation FD disclosure; Other events65
  10. Apr 20, 20268-K Regulation FD disclosure66
  11. Mar 12, 20268-K Results of operations67
  12. Feb 13, 20268-K Entered a material agreement; Other events68
  13. Jan 16, 2007New chief executive Howard W. Robin becomes CEO16
  14. Jun 30, 2006New chief executive Robert Chess becomes CEO18
  15. Jan 13, 2006New chief executive Ajit Gill becomes CEO17
  16. 1990Founded Founded1

Calendar

Coming up

  1. Nov 5, 2026Reports results for the quarter ending Sep/2026 A year earlier it reported ($1.85) a share, on Nov 6, 2025.69

When it reported results

  1. Aug 13, 2026Reported quarterly or annual results60
  2. May 7, 2026Reported quarterly or annual results63
  3. Mar 12, 2026Reported quarterly or annual results67
  4. Nov 6, 2025Reported quarterly or annual results70
  5. Aug 7, 2025Reported quarterly or annual results71
  6. May 8, 2025Reported quarterly or annual results72
  7. Mar 12, 2025Reported quarterly or annual results73
  8. Nov 7, 2024Reported quarterly or annual results74

Drug trials and FDA: recently

  1. Nov 26, 2025Phase 2 trial completed Phase 2 trial of Rezpegaldesleukin in Alopecia Areata: primary completion Nov 26, 2025, no results posted yet (ClinicalTrials.gov NCT06340360).75

Upcoming dates from Nasdaq's calendar; past results from the company's 8-K filings (Item 2.02). Trials from ClinicalTrials.gov, as the sponsor registered them (expected dates are the sponsor's own and often move); approvals and advisory committee meetings from the FDA. The FDA does not publish its decision (PDUFA) dates. The full markets calendar

Filings

398 filings to the SEC since October 2021: 5 annual reports, 15 quarterly reports, 78 major events, 146 insider forms, 57 large holders, 1 private raises, 96 other. The latest 20:

  1. Oct 1, 20268-K CURRENT REPORT EDGAR
  2. Sep 28, 2026SCHEDULE 13G/A EDGAR
  3. Sep 25, 20268-K CURRENT REPORT EDGAR
  4. Sep 25, 20264 EDGAR
  5. Sep 25, 20264 EDGAR
  6. Sep 25, 20264 EDGAR
  7. Sep 25, 20264 EDGAR
  8. Sep 25, 20264 EDGAR
  9. Sep 8, 20268-K CURRENT REPORT EDGAR
  10. Aug 20, 20264 EDGAR
  11. Aug 20, 20264 EDGAR
  12. Aug 18, 2026144 EDGAR
  13. Aug 18, 2026144 EDGAR
  14. Aug 14, 2026S-8 REGISTRATION STATEMENT EDGAR
  15. Aug 14, 202610-Q EDGAR
  16. Aug 14, 2026SCHEDULE 13G/A EDGAR
  17. Aug 14, 2026SCHEDULE 13G/A EDGAR
  18. Aug 13, 20268-K CURRENT REPORT EDGAR
  19. Jul 31, 2026SCHEDULE 13G EDGAR
  20. Jul 29, 2026SCHEDULE 13G EDGAR

The 398 filings since October 2021 can be filtered by form type and year here when JavaScript is on.

Every filing from the last five years, summarized. The full record is on SEC EDGAR.

Insider trades

97 open-market trades by officers, directors and large owners since October 2021: 0 buys and 97 sales. Grants, option exercises and gifts are left out.

DateWhoTradeSharesPriceValueFiling
Aug 18, 2026Zalevsky JonathanChief R&D OfficerSale186$71.98$13.4KForm 4
Aug 18, 2026ROBIN HOWARD WPresident & CEOSale418$71.98$30.1KForm 4
Jun 30, 2026Zalevsky JonathanChief R&D OfficerSale5,681$70.00$397.7KForm 4
Jun 17, 2026ROBIN HOWARD WPresident & CEOSale10,000$61.19$611.9KForm 4
Jun 16, 2026ROBIN HOWARD WPresident & CEOSale10,000$60.32$603.2KForm 4
Jun 15, 2026Zalevsky JonathanChief R&D OfficerSale5,538$60.71$336.2KForm 4
May 19, 2026Zalevsky JonathanChief R&D OfficerSale199$65.51$13.0KForm 4
May 19, 2026ROBIN HOWARD WPresident & CEOSale444$65.51$29.1KForm 4
Feb 18, 2026Zalevsky JonathanChief R&D OfficerSale180$73.00$13.1KForm 4
Feb 18, 2026ROBIN HOWARD WPresident & CEOSale423$73.00$30.9KForm 4
Jan 20, 2026Zalevsky JonathanChief R&D OfficerSale3,867$35.67$137.9KForm 4
Nov 25, 2025Zalevsky JonathanChief R&D OfficerSale1,157$54.28$62.8KForm 4
Nov 25, 2025Wilson Mark AndrewChief Legal OfficerSale630$54.28$34.2KForm 4
Nov 25, 2025ROBIN HOWARD WPresident & CEOSale2,207$54.28$119.8KForm 4
Sep 9, 2025ROBIN HOWARD WPresident & CEOSale6,666$46.69$311.2KForm 4
Sep 5, 2025ROBIN HOWARD WPresident & CEOSale6,666$38.53$256.9KForm 4
Sep 4, 2025Zalevsky JonathanChief R&D OfficerSale1,721$33.52$57.7KForm 4
Sep 4, 2025ROBIN HOWARD WPresident & CEOSale5,166$33.70$174.1KForm 4
Sep 2, 2025Zalevsky JonathanChief R&D OfficerSale485$30.10$14.6KForm 4
Sep 2, 2025ROBIN HOWARD WPresident & CEOSale1,500$30.16$45.2KForm 4

All 97 trades can be filtered by person here when JavaScript is on.

From Forms 4 filed with the SEC.

Major holders

Investors who own more than 5% of the shares must tell the SEC: a 13D if they may seek to influence the company, a 13G if they hold passively.

Executive pay

What the company paid its top executives, from the summary compensation table in its proxy statement. Total pay includes salary, bonus, stock and option awards and other pay, as the company valued them.

YearExecutiveAgeSalaryTotal pay
2025Howard W. RobinPresident and Chief Executive Officer$1.1M$6.3M94
2025Jonathan Zalevsky, Ph.D.Chief Research and Development Officer$717.6K$2.3M94
2025Sandra GardinerInterim Chief Financial Officer$686.4K94
2025Mark A. WilsonFormer Chief Legal Officer$667.9K94
2024Howard W. RobinPresident and Chief Executive Officer$1.1M$3.8M94
2024Jonathan Zalevsky, Ph.D.Chief Research and Development Officer$703.5K$1.6M94
2024Mark A. WilsonFormer Chief Legal Officer$540.0K$1.3M94
2024Sandra GardinerInterim Chief Financial Officer$460.9K94
2023Howard W. RobinPresident and Chief Executive Officer$1.1M$3.1M94
2023Jonathan Zalevsky, Ph.D.Chief Research and Development Officer$703.5K$1.8M94
2023Mark A. WilsonFormer Chief Legal Officer$540.0K$1.1M94
2023Sandra GardinerInterim Chief Financial Officer$376.3K94

Funding

Where the company's money came from, by calendar year: private offerings filed with the SEC, federal grants, loans, contracts and other assistance from USAspending.gov, and PPP loans from the SBA. Each bar links to the records below.

Money received by year$30.0M 2024–2024
Money received by yearMoney received by year, 2024–2024: $30.0M in all. Private raises (Form D) $30.0M.$0$10M$20M$30M2024 · Private raises (Form D): $30.0M2024
Figures by year
YearPrivate raises (Form D)Total
2024$30.0M$30.0M

Private raises

Private offerings the company reported to the SEC on Form D. The amount is what the latest filing says was sold so far, charted in the year of the first sale. Covers filings since Oct 1, 2021.

  1. Mar 4, 2024Raised $30 million in a private offering of equity56 Form D: 1 investor so far Form D

Held by these funds

The largest holders among investment managers' 13F reports for the quarter ending Jun 30, 2026, the top 25 of 100. Change is in shares since the quarter before.

FundSharesValueShare of the fundChange
Fmr LLC5,067,920$353.8M0.0%+764,732
Two Seas Capital LP3,092,234$215.9M8.2%+1,133,056
BlackRock, Inc.2,941,851$205.4M0.0%+2,249,201
Bvf Inc/il2,391,075$166.9M4.3%−168,520
Vanguard Capital Management LLC1,496,849$104.5M0.0%+299,794
Two Sigma Investments, LP1,202,004$83.9M0.1%+271,263
Vestal Point Capital, LP1,000,000$69.8M1.6%+715,000
Morgan Stanley936,560$65.4M0.0%+277,173
State Street Corp909,679$63.5M0.0%+664,952
Geode Capital Management, LLC881,306$61.5M0.0%+534,511
Prosight Management, LP810,000$56.5M9.7%+75,000
Armistice Capital, LLC724,000$50.5M1.4%+146,000
Gilder Gagnon Howe & Co LLC600,873$41.9M0.4%+329,115
Millennium Management LLC478,120$33.4M0.0%+73,843
Braidwell LP473,617$33.1M1.3%+250,916
Sofinnova Investments, Inc.471,763$32.9M1.8%−37,783
Woodline Partners LP470,875$32.9M0.1%+55,540
Orbimed Advisors LLC465,346$32.5M0.6%+190,346
UBS Group AG428,400$29.9M0.0%+108,228
Emerald Advisers, LLC390,158$27.2M0.6%−4,446
Vanguard Portfolio Management LLC348,540$24.3M0.0%+276,049
DAFNA Capital Management LLC318,380$22.2M4.2%+153,202
Northern Trust Corp308,531$21.5M0.0%+229,933
Deep Track Capital, LP300,000$20.9M0.3%New
Charles Schwab Investment Management Inc284,971$19.9M0.0%+116,964

13F reports cover disclosed long positions in U.S. stocks only.

SEC filer profile

How Nektar Therapeutics is registered with the Securities and Exchange Commission, from its EDGAR record and the cover page of its latest annual report.

  • Name on EDGARNEKTAR THERAPEUTICS2
  • CIK0000906709
  • Employer ID (EIN)94-313494015
  • Filer statusNon-accelerated filer not an emerging growth company; a smaller reporting company; not a shell company15
  • Incorporated inDelaware15
  • Fiscal year endsDecember 312
  • Industry code (SIC)2834 Pharmaceutical Preparations2
  • SEC reviewing officeOffice of Life Sciences, Division of Corporation Finance2
  • Business address455 Mission Bay Boulevard South, San Francisco, CA 941582
  • Phone41548253002
  • Shares outstanding34,142,994 as of Aug 7, 202613
  • Public float$318.0M as of Jun 30, 202515
  • AuditorErnst & Young LLP, San Mateo, California PCAOB ID 42; no auditor attestation of internal control over financial reporting15
  • On EDGAR sinceFeb 14, 19962
  • Filings1,979 in all: 4 (874), 8-K (358), SC 13G/A (142), 10-Q (91), 144 (54), 4/A (54), SC 13G (42), 424B3 (38)2
    All 46 form types

    3 (32), 10-K (30), DEF 14A (30), S-8 (30), SCHEDULE 13G/A (17), 424B5 (16), DEFA14A (16), S-3 (15), UPLOAD (14), CORRESP (12), S-3/A (12), 10-K/A (10), SCHEDULE 13G (10), 8-K/A (9), CT ORDER (9), ARS (8), 424B7 (6), 5 (6), REGDEX (6), S-3ASR (5), POS AM (4), SC 13D (4), PRE 14A (3), 10-Q/A (2), 3/A (2), 424B4 (2), D (2), EFFECT (2), RW (2), SC TO-I/A (2), 424B1 (1), 425 (1), DRS (1), DRSLTR (1), NTN 10K (1), S-8 POS (1), SC TO-I (1), SD (1)

  • Latest filingsAnnual report (10-K) Mar 13, 2026
    Quarterly report (10-Q) Aug 14, 2026
    Proxy statement (DEF 14A) Apr 24, 2026
    Latest 8-K (8-K) Oct 1, 2026

Securities registered for trading

ClassSymbolExchange
Common Stock, $0.0001 par valueNKTRNASDAQ

From the cover page of the 10-K filed Mar 13, 2026 (Section 12(b) of the Exchange Act).15

Risk factors and legal proceedings

The risks Nektar Therapeutics names in Item 1A of its 10-K filed Mar 13, 2026: 47 risks under these headings, as written.15

  • Risks Related to our Business
  • We are highly dependent on the success of drug candidates, particularly rezpegaldesleukin (previously referred to as NKTR-358). If these drug candidates fail in clinical development our business will be significantly harmed.
  • Delays in clinical studies are common and have many causes, and any significant delay in clinical studies being conducted by us or our partners could result in delay in regulatory approvals and jeopardize the ability to proceed to commercialization.
  • We currently rely on academic and private non-academic institutions to conduct investigator-sponsored clinical studies or trials of our drug candidates. Any failure by the investigator-sponsor to meet its obligations with respect to the clinical development of our drug candidates may delay or impair our ability to obtain regulatory approval or commercialize for other drug candidates.
  • The outcomes from the clinical trials of drug candidates from others, and the discovery and development of new potential therapies in immunology and oncology, could have a material and adverse impact on the value of the drug candidates in our research and development pipeline.
  • The risk of clinical failure for any drug candidate remains high prior to regulatory approval and there can be no assurance that our drug candidates will obtain regulatory approval for any particular indications.
  • Significant competition could render our partnered and proprietary drugs and drug candidates obsolete or noncompetitive, which would negatively impact our business, results of operations and financial condition.
  • Preliminary and interim data from our clinical studies that we announce or publish from time to time are subject to audit and verification procedures that could result in material changes in the final data and may change as more patient data become available.
  • Risks Related to our Financial Condition and Capital Requirement
  • Our results of operations and financial condition depend significantly on the ability of our collaboration partners to successfully develop and market drugs and they may fail to do so.
  • We have substantial future capital requirements and there is a risk that we may not have access to sufficient capital to meet our current business plan. If we are unable to raise additional capital in one or more financing transactions, execute new high value collaborations or other arrangements, or do not receive substantial milestone or royalty payments from our existing collaboration agreements, we would be unable to continue our current level of investment in research and development.
  • The commercial potential of a drug candidate in development is difficult to predict. If the market size for a new drug is significantly smaller than we anticipate, it could significantly and negatively impact our revenue, results of operations and financial condition.
The other 37 risks
  • If government and private insurance programs do not provide payment or reimbursement for our partnered drug or proprietary drugs, those drugs will not be widely accepted, which would have a negative impact on our business, results of operations and financial condition.
  • If we are unable to establish and maintain collaboration partnerships on attractive commercial terms, our business, results of operations and financial condition could suffer.
  • Our revenue has historically been exclusively derived from our collaboration agreements, which can result in significant fluctuation in our revenue from period to period, and our past revenue is therefore not necessarily indicative of our future revenue.
  • We expect to continue to incur substantial losses and negative cash flow from operations and may not achieve or sustain profitability in the future.
  • Additional cost-savings measures may be necessary following implementation of our strategic reorganization plan and cost restructuring plans.
  • Risks Related to Supply and Manufacturing
  • If our contract manufacturers are not able to manufacture biologic substance or substances in sufficient quantities that meet applicable quality standards, it could delay clinical studies or constitute a breach of our contractual obligations, any of which could significantly harm our business, financial condition and results of operations.
  • Our CMOs purchase some of the starting material for biologics and biologic candidates from a single source or a limited number of suppliers and we are dependent on Gannet BioChem for the suppy of the PEG reagents, and the partial or complete loss of one of these suppliers could cause production delays and clinical trial delays.
  • The manufacturing operations of our contract manufacturers are subject to laws and other governmental regulatory requirements, which, if not met, would have a material adverse effect on our business, results of operations and financial condition.
  • Risks Related to Business Operations
  • We depend on third parties to conduct the preclinical studies and clinical trials for our drug candidates and any failure of those parties to fulfill their obligations according to protocol standards could harm our development plans and adversely affect our business.
  • Our future depends on the proper management of our current and future business operations and their associated expenses.
  • Because competition for highly qualified technical personnel is intense, we may not be able to attract and retain the personnel we need to support our operations and growth.
  • We are dependent on our management team and key technical personnel, and the loss of any key manager or employee may impair our ability to develop our products effectively and may harm our business, operating results and financial condition.
  • Inflation has increased our operating costs and could negatively impact our operations.
  • Our business could be adversely affected by the effects of future health epidemics.
  • Risks Related to Intellectual Property, Litigation and Regulatory Concerns
  • If we or our partners do not obtain regulatory approval for our drug candidates on a timely basis, or at all, or if the terms of any approval impose significant restrictions or limitations on use, our business, results of operations and financial condition will be negatively affected.
  • We may seek orphan drug status or Breakthrough Therapy or Fast Track designations or other designation for one or more of our drug candidates, but even if any such designation or status is granted, it may not lead to a faster
  • development process or regulatory review and may not increase the likelihood that our drug candidates will receive marketing approval, and we may be unable to maintain any benefits associated with such designations or status, including market exclusivity.
  • Even if we receive regulatory approval of our drug candidates, we will be subject to ongoing regulatory obligations and continued regulatory review, which may result in significant additional expense and we may be subject to penalties if we fail to comply with regulatory requirements or experience unanticipated problems with our drug candidates.
  • We are a party to numerous collaboration agreements and other significant agreements which contain complex commercial terms that could result in disputes, litigation or indemnification liability that could adversely affect our business, results of operations and financial condition.
  • We may not be able to obtain intellectual property licenses related to the development of our drug candidates on a commercially reasonable basis, if at all.
  • If any of our pending patent applications do not issue, or are deemed invalid following issuance, we may lose valuable intellectual property protection.
  • We rely on trade secret protection and other unpatented proprietary rights for important proprietary technologies, and any loss of such rights could harm our business, results of operations and financial condition.
  • If product liability lawsuits are brought against us, we may incur substantial liabilities.
  • If we or current or future collaborators or service providers fail to comply with healthcare laws and regulations, we or they could be subject to enforcement actions and civil or criminal penalties.
  • Healthcare legislative or regulatory reform measures may have a negative impact on our business and results of operations.
  • Disruptions to the normal functioning of the FDA and other government agencies could hinder their ability to perform and carry out important roles and activities on which the operation of our business relies, which could negatively impact our business.
  • We are involved in legal proceedings and may incur substantial litigation costs and liabilities that will adversely affect our business, financial condition and results of operations.
  • Any actual or alleged (failure to comply with privacy and data protection laws, could subject us to fines, penalties, increased regulatory scrutiny, or suspension or exclusion from participation in government healthcare programs. Any of these outcomes could adversely affect our business, financial condition and results of operations.
  • Like many companies, we may use artificial intelligence (AI) technologies, including generative AI, which presents risks and challenges that can impact our business, including by posing cybersecurity risks to our confidential information, proprietary information, and personal data.
  • Our operations may involve hazardous materials and are subject to environmental, health, and safety laws and regulations. Compliance with these laws and regulations is costly, and we may incur substantial liability arising from our activities involving the use of hazardous materials.
  • Risk Related to Investment and Securities
  • The price of our common stock has, and may continue to fluctuate significantly, which could result in substantial losses for investors and securities class action and shareholder derivative litigation.
  • We have implemented certain anti-takeover measures, which make it more difficult to acquire us, even though such acquisitions may be beneficial to our stockholders.
  • General Risk Factors
  • We significantly rely on information technology systems and infrastructure, and any failure, inadequacy, damage, interruption, compromise, incident or breach, or security lapse of that technology within our internal computer systems and infrastructure, or those of our partners, vendors, CROs, CMOs or other contractors or consultants, may result in a material disruption of our development programs and our operations and financial condition.
  • Changes in tax law could adversely affect our business and financial condition.
  • Global economic and political conditions may negatively affect us and may magnify certain risks that affect our business.
  • Our business could be negatively impacted by corporate citizenship and sustainability matters.
  • If natural disasters or other catastrophic events strike, our business may be harmed.

Legal proceedings

From time to time, we are subject to legal proceedings. We are not currently a party to or aware of any proceedings that we believe will have, individually or in the aggregate, a material adverse effect on our business, financial condition or results of operations.

The opening of Item 3, Legal Proceedings.15

Sources

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