Private company

Otsuka Pharmaceutical

Logo: Otsuka Holdings, Public domain, via Wikimedia Commons4

Japanese pharmaceutical company

Otsuka Pharmaceutical Co., Ltd. (大塚製薬株式会社, Ōtsuka Seiyaku Kabushiki-gaisha), abbreviated OPC, is a pharmaceutical company headquartered in Chiyoda, Tokyo. The company was established on August 10, 1964.2 It is part of Otsuka Holdings.1 Wikipedia text CC BY-SA 4.0

Last updated Oct 21, 2026.

Overview

Aug 10, 1964Founded1
  • Industrypharmaceutical industry1
  • HeadquartersChiyoda1
  • Websitewww.otsuka.co.jp
  • Legal formkabushiki gaisha1
  • LEI353800T027BNMJ8BG8583
  • StatusActive3
  • LEI statusIssued and current3
  • Registered address神田司町二丁目9番地, 101-8535 東京都 千代田区, Japan3
  • Registered withLegal Affairs Bureau, 0100-01-0129863
Ootsukagroup
Photo: Kattin, CC BY-SA 3.0, via Wikimedia Commons6

Otsuka Pharmaceutical Co., Ltd. (大塚製薬株式会社, Ōtsuka Seiyaku Kabushiki-gaisha), abbreviated OPC, is a pharmaceutical company headquartered in Chiyoda, Tokyo. The company was established on August 10, 1964.2

Corporate structure

Otsuka Pharmaceutical is part of a group headed by Otsuka Holdings. 19 entities, 4 countries on record. Switch between the flow chart and the network, and select any entity to see its details.

Built from parent and subsidiary links from GLEIF, the Global Legal Entity Identifier Foundation (CC0); subsidiaries, stakes and holdings from Wikidata (CC0); major holders from Schedules 13D and 13G. Each entity in the chart links to its source.

What it owns

What Otsuka Pharmaceutical reports owning in its annual reports to the SEC: buildings, land and equipment, real estate and locations, investments, intangible assets and inventory, at the end of its latest fiscal year and a year before.

Stakes and holdings (Wikidata)

  • Tokushima Vortis

Things Wikidata records the company as owning, with the share when stated.1

The story

OPC's parent company Otsuka Holdings Co. Ltd. joined the Tokyo Stock Exchange through an initial public offering (IPO) on December 15, 2010, at which time Otsuka Holdings was Japan's No. 2 drug maker by sales after industry leader Takeda Pharmaceutical Company. The IPO debuted at $2.4 billion, making it the largest for a pharmaceutical company up to that time.

Otsuka Pharmaceutical Co. Ltd Holdings

In 1955, the company started a football club called "Otsuka Pharmaceutical SC." In 2005 the name changed to Tokushima Vortis. The club is based in Naruto.

In 1988, Otsuka acquired Pharmavite, the California-based manufacturer of Nature Made, MegaFood, and other brands of vitamins and nutritional supplements.

In 2008, Otsuka Pharmaceutical Co. acquired 49% of Alma S.A., which is the parent company of CG Roxane.

In early 2012, Otsuka announced it would focus its "future operations on CNS disorders and oncology". This decision necessitated a revision in the terms of an agreement with UCB to end collaboration on immunology products while continuing collaboration in the CNS area.

In March 2017, the company agreed to acquire Neurovance, Inc. for $250 million, gaining the firm's Phase III-ready ADHD drug centanafadine (previously EB-1020). Otsuka's subsidiary Otsuka America will pay $100 million upfront for Neurovance, plus up-to $150 million in development and approval milestones. As a result of the transaction, Neurovance will operate as an indirect, wholly owned subsidiary.

In late 2023, the company announced the acquisition of Mindset Pharma for $58.6 million.

In March 2026, Otsuka Pharmaceutical acquired Transcend Therapeutics and its drug candidate methylone (TSND-201).

From Wikipedia’s article on Otsuka Pharmaceutical, shared under CC BY-SA 4.0.5

Products and brands

Products

Pharmaceutical

Aripiprazole / Abilify

Brexpiprazole / Rexulti

Rejoyn

Nutraceutical

Amino-Value

Read the full text

CalorieMate

Oronamin C

Pocari Sweat

SoyJoy

Facilities

Takasaki

Fukuroi

Saga

Tokushima

Itano

Wajiki

From Wikipedia’s article on Otsuka Pharmaceutical, shared under CC BY-SA 4.0.5

Subsidiaries and ownership

Parent company

Subsidiaries

Also owns

  • Tokushima Vortis

From Wikidata.1

Acquisitions

  1. 2013Astex Pharmaceuticals became a subsidiary1
  2. 2013Astex Therapeutics became a subsidiary1
  3. 1999Acquired Otsuka Pharmaceutical Factory1

Timeline

  1. Jul 8, 2008Acquired Acquired by Otsuka Holdings1
  2. Aug 10, 1964Founded Founded1