Private company
Paradigm Biocapital Advisors LP
Limited partnership registered in the United States, active since 2020. Summary from the record
Last updated Oct 21, 2026.
Overview
- HeadquartersNew York, United States2
- Legal formLimited Partnership2
- Kind of organizationLimited partnership2
- LEI549300I649YOM8XI0E932
- StatusActive2
- LEI statusIssued and current2
- Registered addressC/O CORPORATION SERVICE COMPANY, 19808 Wilmington, United States2
- Registered withDivision of Corporations, Department of State, 31158372
Corporate structure
Paradigm Biocapital Advisors LP sits at the top of its group. 40 entities, 3 countries on record. Switch between the flow chart and the network, and select any entity to see its details.
Major holders of Paradigm Biocapital Advisors LP
- Dr. Senai Nmn Asefaw Owns 75% or more of Paradigm Biocapital Advisors LP, since 12/2020 (Form ADV)
- Paradigm Biocapital Advisors LP New York, New York, United States
- ACHIEVE LIFE SCIENCES, INC. Stake · Bothell, Washington, United States
- Aeglea BioTherapeutics Stake · Austin
- Agios Pharmaceuticals Stake · Cambridge, Massachusetts, United States
- Alpine Immune Sciences Stake · Boulder, Colorado, United States
- Ambrx Biopharma Cayman, Inc. Stake · La Jolla, California
- Ambrx Biopharma, Inc. Stake · La Jolla, California
- Arcellx, Inc. Stake · Redwood City, California
- ASSEMBLY BIOSCIENCES, INC. Stake · Wilmington, Delaware, United States
- Autolus Therapeutics Stake · London, United Kingdom
- Bicycle Therapeutics (United Kingdom) Stake · Cambridge, United Kingdom
- Cidara Therapeutics Stake · San Diego, California, United States
- Cogent Biosciences, Inc. Stake · Waltham, Massachusetts
- Compass Pathways Stake · Altrincham, United Kingdom
- Corbus Pharmaceuticals Stake · Norwood, Massachusetts, United States
- Disc Medicine, Inc. Stake · Watertown, Massachusetts
- Edgewise Therapeutics, Inc. Stake · Boulder, Colorado
- Erasca, Inc. Stake · San Diego, California
- EyePoint Pharmaceuticals Stake · Watertown, Massachusetts, United States
- Jade Biosciences, Inc. Stake · Waltham, Massachusetts
- Janux Therapeutics, Inc. Stake · San Diego, California
- Kura Oncology Stake · La Jolla, California, United States
- LENZ Therapeutics, Inc. Stake · Solana Beach, California
- Lexeo Therapeutics, Inc. Stake · New York, New York
- Maze Therapeutics, Inc. Stake · South San Francisco, California
- MBX Biosciences, Inc. Stake · Carmel, Indiana
- and 14 more
Built from parent and subsidiary links from GLEIF, the Global Legal Entity Identifier Foundation (CC0); stakes of 5% or more it reported on Schedules 13D and 13G (37 companies); owners and owned firms from Form ADV, the registration investment advisers file with the SEC. Each entity in the chart links to its source.
Investment adviser
Paradigm Biocapital Advisors LP is registered with the SEC as an investment adviser. This is what it reports on Form ADV, the registration every adviser files and keeps current.
- Assets it manages$4.5B3 4 accounts, all with discretion
- Employees11 6 in investment advice or research
- ClientsPooled investment vehicles (other than investment companies and: 3 ($4.0B); Other: SEPARATELY MANAGED ACCOUNT: 1 ($465.0M)
- How it is paidA percentage of assets under its management; Performance-based fees
- What it doesPortfolio management for pooled investment vehicles (other than investment companies)
- Holds client assetsYes: cash and securities
- RegistrationSEC 801-120338, CRD 312544 IAPD record
Who owns it
Owners of 5% or more as the firm lists them (Schedule A), and the owners of those owners up the chain (Schedule B).
- Dr. Senai Nmn Asefawowns 75% or more, since 12/2020
- Dr. Senai Nmn Asefawowns 75% or more of PARADIGM, since 01/2022
In its own words: the client brochure
Form ADV Part 2A, the plain-English document an adviser must give its clients, quoted as filed 5/27/2026.4 It covers the firm’s services, fees, investment strategies and their risks, and its conflicts of interest.
Item 4: Advisory business Services
Paradigm BioCapital Advisors LP (“PBCA”, the “Firm” or the “Investment Manager”) is a Delaware limited partnership that was formed in July 2020. The general partner of PBCA is Paradigm BioCapital Advisors GP LLC (“PBCAGP”). Dr. Senai Asefaw (the “Principal”) is the managing member and principal owner of PBCAGP. PBCA provides investment advisory services to private funds via a master-feeder structure, whereby Paradigm BioCapital Partners Fund, LP (the “Domestic Fund”), a Delaware limited partnership, and Paradigm BioCapital Partners Fund, Ltd. (the “Offshore Fund”), a Cayman Islands exempted company together with the Domestic Fund, the “Feeder Funds”, invest substantially all of their assets in Paradigm BioCapital International Fund Ltd. (the “Master Fund”), a Cayman Islands exempted company. Unless otherwise specified, the Domestic Fund, the Offshore Fund and the Master Fund are each referred to as a “Fund” and collectively, as the “Funds”. Additionally, PBCA manages one separately managed account on a discretionary basis pursuant to an Investment Management Agreement with the underlying investor (the “SMA”). Hereinafter, where applicable, the Funds and the SMA are collectively referred to as the “Clients”. PBCA manages the Funds pursuant to investment guidelines set forth in the relevant governing and offering documents of the Funds, including any limited partnership agreement, investment management agreement, private placement memorandum and/or subscription agreement (each an “Offering Document”, and collectively, the “Offering Documents”). The Offering Documents contain more detailed information about the Funds, including a description of the investment objective and strategy or strategies employed by the Funds and related restrictions that serve as a limitation on PBCA’s advice or management. PBCA will not tailor its advisory services to the individual investors in the Funds (each an “Investor” and collectively the “Investors”), or provide Investors with the right to specify, or restrict the Funds’ investment objectives or any investment or trading decisions. Accordingly, an investment in a Fund does not create a client-adviser relationship between such Investors and PBCA. Each of the Funds are expected to rely on the exception from the definition of an “investment company” provided by Section 3(c)(7) of the U.S. Investment Company Act of 1940, as amended (the “1940 Act”). Each Investor is strongly encouraged to undertake appropriate due diligence, including but not limited to a review of relevant Offering Documents and the additional details about PBCA’s investment strategies, methods of analysis and related risks (as discussed in Item 8 of this Brochure and each Fund’s Offering Documents) in considering whether PBCA’s advisory services or an investment in a Fund is appropriate to its own circumstances, based on all relevant factors including, but not limited to, the Investor’s own investment objectives, liquidity requirements, tax situation and risk tolerance before making an investment decision. The general partner of the Domestic Fund and management company of the Master Fund and Offshore Fund is Paradigm BioCapital GP LLC (the “General Partner”), a Delaware limited liability company. The General Partner has ultimate responsibility for decisions relating to management and operations made on behalf of the Domestic Fund and the Master Fund and has ultimate responsibility for the investment decisions made on behalf of the Master Fund but has delegated certain responsibilities to PBCA. Additional detailed information about PBCA is provided below, including information about PBCA’s advisory services, investment approach, personnel and affiliations. PBCA does not participate in wrap fee programs. PBCA currently provides discretionary investment advisory services to the Clients with a total of $4,469,161,523 in regulatory assets under management.
Item 5: Fees and compensation Fees
As an investment adviser to the Funds, as further described in the Offering Documents, PBCA receives an annual management fee generally equal to 1.5%. The management fees are paid by the Master Fund monthly in advance on the first day of each month, depending upon the net asset value of the Funds and each particular investment by an Investor in the Funds. Management fees are generally pro-rated for partial periods. Once paid, management fees are non-refundable. The Firm or its affiliates may reduce, waive or calculate differently the management fee for certain Investors, including but not limited to, members, employees and affiliates of PBCA. Other Fees and Expenses The Feeder Funds will bear their own expenses and their pro rata share of the Master Fund’s expenses, including, without limitation, Operating Expenses (as hereinafter defined) and Organizational Expenses (as hereinafter defined), and shall reimburse PBCA, the General Partner or any of their respective affiliates for any Operating Expenses and Organizational Expenses incurred by such persons. Organizational and Initial Offering Expenses The Feeder Funds will pay or reimburse PBCA, the General Partner, and/or affiliates of PBCA for all organizational and initial offering expenses of the Funds, including, but not limited to, legal and accounting fees, printing and mailing expenses and government filing fees (including “blue sky” filing fees). The Funds’ organizational and initial offering expenses may be, for accounting purposes, capitalized and amortized by the Funds for up to 60 months from the date the Funds commence operations. Amortization of such expenses is a divergence from U.S. generally accepted accounting principles (“GAAP”). In certain circumstances, this divergence may result in a qualification of the Funds’ annual audited financial statements. In such instances, the Funds may elect to: (i) avoid the qualification by recognizing the unamortized expenses, or (ii) make GAAP-conforming changes for financial reporting purposes, but capitalize and amortize expenses for purposes of calculating the Funds’ Net Asset Value (resulting in a divergence in fiscal year-end Net Asset Values reported in the Funds’ financial statements, and as otherwise applicable under the provisions of the Offering Documents). If the Funds capitalize and amortize such expenses and are then terminated within 60 months of their commencement, any unamortized expenses will be recognized. If an Investor in a Fund makes a withdrawal prior to the end of the period during which the particular Fund is capitalizing and amortizing expenses, the Fund may, but is not required to, accelerate a proportionate share of the unamortized expenses based upon the amount being withdrawn and reduce withdrawal proceeds accordingly. Operating Expenses Each Fund will incur its own expenses. The expenses and results of operations of the Master Fund will be allocated to the Feeder Funds and the other Investors in the Master Fund, in proportion to the capital accounts of the Feeder Funds and such other investors in the Master Fund, from time to time. The Funds will pay or reimburse PBCA, the General Partner, and/or affiliates of PBCA for: (i) all expenses incurred in connection with the ongoing offer and sale of interests, including, but not limited to, printing of the Offering Documents and exhibits, marketing expenses and documentation of performance and the admission of Investors, (ii) all operating expenses of the Funds, such as tax preparation fees, governmental fees and taxes, administration fees paid to the Fund Administrator providing services to the Funds, costs of communications with Investors, and ongoing legal, accounting, auditing, bookkeeping, consulting and other professional fees and expenses, (iii) all research, trading and investment-related costs and expenses (e.g., brokerage commissions, research fees, margin
interest, expenses related to short sales, custodial fees, bank service fees, and clearing and settlement charges) of the Funds, (iv) technology-related costs and expenses, including, but not limited to, software licenses, data feeds and colocation expenses, (v) all expenses related to attending any conference or seminar related to alternative investments (e.g., registration, transportation, accommodation or meal expenses), (vi) regulatory and other filing fees and expenses, and compliance costs and expenses of the Funds, including, but not limited to, all fees and expenses incurred by PBCA and/or its affiliates directly in connection with examinations by the SEC and other regulatory authorities that are attributable to the Funds, as well as fees and expenses associated with the completion of regulatory filings that are attributable to the Funds (including, without limitation, Form PF filings), (vii) travel expenses related to meeting with management teams, or related to any of the other categories of expenses set forth herein, (viii) any costs and expenses incurred by the Funds in connection with converting from a “feeder fund” as part of a master-feeder structure into a standalone fund, (ix) director and officer liability insurance or other insurance premiums for any principal or employee of the Funds, PBCA, the General Partner, or any affiliates of PBCA, (x) all fees and other expenses incurred in connection with the investigation, prosecution or defense of any claims, assertion of rights or pursuit of remedies, by or against the Funds, including, without limitation, professional and other advisory and consulting expenses, and (xi) any and all costs and expenses incurred in connection with the dissolution, winding-up, or termination of one or more of the Funds. Each of PBCA, the General Partner, or any affiliates of PBCA, in its sole discretion, may from time to time pay for any of the foregoing expenses of the Funds. Any such person may elect to be reimbursed for such expenses, or to waive its right to reimbursement for any such expenses, as well as terminate any such voluntary payment or waiver of reimbursement. PBCA’s Expenses PBCA or their affiliates will pay their own general operating and overhead expenses associated with providing the management and investment management services required under the Offering Documents. These expenses include all expenses incurred by PBCA in providing for their normal operating overhead, including, but not limited to, the cost of providing relevant support and administrative services (e.g., employee compensation and benefits, rent, office equipment, computer systems, insurance (other than as expressly set forth above), utilities, telephone, secretarial and bookkeeping services, etc.), but not including any operating expenses of the Funds described above. PBCA may use “soft dollar” commissions or rebates by brokerage firms of commissions generated by the Funds’ brokerage transactions executed through those firms to pay for certain brokerage and research products and services that fall within the safe harbor under Section 28(e) of the Securities Exchange Act of 1934, as amended (“Exchange Act”). If any of the expenses listed above are incurred jointly for the account of the Feeder Funds (or the Master Fund) as well as for any other accounts, such expenses will be allocated among the Feeder Funds (or the Master Fund) and such other accounts in proportion to their respective net asset values, based on the amount invested in a position or in such other manner as PBCA considers fair and equitable, in its sole discretion. The Funds have a determined limit of 0.35% on their ordinary, recurring operating expenses as defined in each Fund’s Offering Documents. Each Fund’s actual annual operating expenses will be disclosed in each Fund’s year-end audited financial statements, which are provided to each Investor in the particular Fund. PBCA has adopted policies and procedures intended to address trade errors to ensure that the Funds are treated fairly. Subject to any contractual limitations set forth in each Fund’s Offering Documents, PBCA has discretion to resolve a particular error in a manner that it deems appropriate and consistent with PBCA’s policies and procedures.
For information on the Firm’s brokerage and transaction costs, please see “Item 12 – Brokerage Practices.”
Item 8: Methods of analysis, investment strategies and risk of loss Investment strategies and risks
Investment Objective PBCA’s investment objective in managing the Clients is to seek attractive risk-adjusted returns for the Investors by investing in a diversified portfolio of various healthcare and therapeutics-related investments. For the purposes of this Item 8, the SMA should also be considered to have the same investment strategy and risks as the Funds. Investment Strategy PBCA intends to seek to achieve the investment objective of the Funds through, among other things, rigorous fundamental research. Three fundamental tenets will generally drive PBCA’s overall strategy: 1. Innovation in Biotechnology: The culmination of the Human Genome Project in 2003 laid the foundation for a wave of innovation in the life sciences. A decade later, the scientific advances began to translate into the clinic with a surge in novel therapeutics. This has led to strong outperformance by the biotechnology sector in the past decade and has driven capital and talent inflows into company formation. PBCA believes that this virtuous cycle continues unabated with a large and growing proportion of important novel drugs originating in the small and mid-cap biotechnology sector. PBCA’s core strategy is to invest in companies developing such “paradigm shifting” drugs as soon as there is a proof of concept and accrue substantial gains for investors while minimizing risk. 2. Sector Volatility and Idiosyncratic Stock Movements: PBCA believes that the biotechnology sector is characterized by volatility driven by sentiment extremes and idiosyncratic stock movements based on clinical and regulatory updates. This should provide sector specialists opportunities to identify investments with asymmetric risk/reward profile. PBCA intends to seek such opportunities on a selective basis with an emphasis on sentiment-based volatility. 3. Risk Management: Traditional biotechnology investing has focused on the “catalyst calendar” of several hundred important clinical and regulatory updates that drive large movements in stocks. PBCA intends to discriminate in investing ahead of such “binary” events and focuses on a limited
number of situations where there is unusual conviction based on differentiated scientific or medical insights and otherwise opts to invest after the catalyst. PBCA believes that prioritizing capital preservation and avoiding investments with significant risk of capital loss assiduously optimizes returns, as well as reduces risk and volatility. In furtherance of the aforementioned principles, PBCA seeks to identify individual investments representing high conviction, fundamental long and short positions. The time horizon for long investments may range from a few months to up to 24 months depending on the specific investment thesis. PBCA may utilize leverage (including margin loans) on behalf of the Funds to achieve its investment objective. Short selling is also expected to be an important component of PBCA’s investment strategy. Investment Process PBCA intends to invest the assets of the Funds globally in companies of all market capitalizations, primarily through investments in equity securities, ADRs, U.S. and non-U.S. listed options, total return and equity swaps (including basket), and exchange-traded funds (“ETFs”). PBCA may also invest the Funds’ assets in debt securities, convertible securities, options and warrants of these companies. PBCA anticipates that the investment universe for the Funds will include approximately 350 companies in the innovative biotechnology sector. PBCA’s investment team will closely monitor the progress and execution of this group of companies, as well as the broader context of treatments in development to identify opportunities to deploy the investment strategy. Investment ideas are primarily generated internally from this monitoring process. In addition, ideas may be sourced externally and subsequently vetted through the internal security selection process. Security selection for the portfolio will be based on fundamental analysis. This includes quantitative and qualitative scientific and medical due diligence, interviews with management teams and competitors, discussions with medical and industry experts, and detailed review of a company’s financial statements and review of its strategy and capital position. Portfolio Construction and Risk Management In managing the Funds, PBCA intends to construct a portfolio that leverages the opportunities identified from the investment process. Portfolio construction is expected to focus on risk management and balancing exposures. Risk will be quantified and managed at both the position and portfolio level. Position-level risk management will focus primarily on sizing. Where appropriate, options may be used in lieu of equity to seek to minimize the probability that large losses will develop. All positions are expected to be tracked, and, at certain pre-specified levels, the investment thesis will be re-examined; if the original thesis is flawed, a position exit may be triggered or a potential further buying opportunity may be identified. For short positions, levels will be established to trigger partial liquidation. Portfolio-level risk management seeks to manage aggregate risks of the portfolio, such as: (a) net and gross exposures, and (b) long and short exposures relative to the specific profile of the investments. As set forth above, PCBA may utilize leverage in managing the Funds in an effort to realize greater profits from its security selection. The Funds may make use of leverage by: (a) borrowing money against long positions in order to purchase additional long positions, and (b) borrowing securities and shorting those securities in the market. The portfolio-level net exposure will generally be a result of fundamentally driven security selection and not the view of the overall market. However, market levels relative to trends will help guide net exposures.
Summary of Material Risks There can be no assurance that PBCA’s investment objective in managing the Funds will be achieved, and that the Funds will not incur losses. The risks described below are not meant to be a comprehensive collection of all risks with which the Funds will be confronted. Each Investor is also encouraged to consult with PBCA to review the specific risk parameters of, and assets that comprise, each Fund at any given time and from time to time. Risk of Loss Factors Investing in securities involves risk of loss that investors should be prepared to bear. The following list of risk factors does not purport to be a complete enumeration or explanation of the risks involved in an investment in the Funds. Each Fund’s Offering Documents provides a detailed description of the risks of investing in the Funds. Limited or Lack of Operating History PBCA and the Funds are recently formed entities and have little or no operating history upon which prospective investors may evaluate the Funds’ future performance. Although the Principal has experience with investments of the type the Funds intend to make, any prior performance of the Principal or PBCA is not necessarily indicative of results that they may achieve with respect to the Funds. As such, there can be no assurances that PBCA will be able to implement its investment strategy for the Funds, or achieve its investment objective for the Funds. Reliance on the Principal The success of the Funds depends in large part upon the skill, knowledge, judgment, experience and expertise of the Principal to develop and implement investment strategies that achieve the Funds’ investment objective. There can be no assurance that the Principal will continue to be associated with the Funds or the Investment Manager. In the event the Principal ceases to devote sufficient time to the management of the Funds, in its reasonable judgment determined necessary to accomplish the purposes of the Funds, there might be an adverse effect on the Funds. Dependence on Service Providers PBCA relies on service providers for certain aspects of their business, including certain financial operations, trade related activity, IT infrastructure and systems, trade reconciliation, and margin and collateral movement. PBCA does not control or direct these service providers and have limited transparency into such businesses’ day-to-day operations. Any interruption or deterioration in the performance of such service providers could impair the quality of PBCA’s operations, negatively impact its reputation and the reputation of the Funds and the investment strategies of the Funds, limit the Funds’ potential to grow, and ultimately expose the Investors to losses. Limited Liquidity of Interests An investment in the Funds involves substantial restrictions on liquidity and its interests are not freely transferable. There is no market for the interests in the Funds, and no market is expected to develop. Additionally, transfers are subject to the consent of PBCA or the General Partner, which consent may be granted or withheld in PBCA’s or the General Partner’s sole discretion. Consequently, Investors will be unable to liquidate their interests except by withdrawing from the Funds in accordance with the Offering Documents of the Feeder Funds. Investors may be unable to liquidate their investment promptly in the event of an emergency or for any other reason. Although an Investor may attempt to increase its liquidity by borrowing from a bank or other institution, interests may not readily be
accepted as collateral for a loan. In addition, the transfer of an interest as collateral or otherwise to achieve liquidity may result in adverse tax consequences to the transferor. A portion of the Master Fund’s assets may be invested in securities and other financial instruments or obligations for which no market exists and/or which are restricted as to their transferability under federal or state securities laws. Because of the absence of any trading market for these investments, the Funds may take longer to liquidate these positions than would be the case for publicly traded securities. Although these securities may be resold in privately negotiated transactions, the prices realized on these sales could be less than those originally paid by the Funds. Further, companies whose securities are not publicly traded may not be subject to public disclosure and other investor protection requirements applicable to publicly traded securities. Lack of Registration The interests of the Funds have neither been registered under the Securities Act nor under the securities laws of any state and, therefore, are subject to transfer restrictions. In connection with an Investor’s purchase of an interest, the Investor must represent that they are purchasing the interest for investment purposes only and not with a view toward resale or distribution. Neither the Funds nor PBCA or its affiliates have any plans or assumed any obligation to register the interests. Accordingly, the interests may not be transferred without documentation acceptable to the General Partner, which may include an opinion of counsel to the Funds that the transfer will not involve a violation of the registration requirements of the Securities Act or require registration by the Funds under the 1940 Act. These restrictions on transfer are in addition to those found in the Offering Documents. Ordinarily, this means that transfers will be restricted to instances of death, gift or passage by operation of law. No Guarantee of Return or Performance The obligations or performance of the Funds or the returns on investments in the Funds are not guaranteed in any way. Any losses of the Funds will be borne solely by Investors in the Funds. Ownership interests in the Funds are not insured by the Federal Deposit Insurance Corporation, and are not deposits, obligations of, or endorsed or guaranteed in any way, by any banking entity. Risk Associated with Information Used in the Research Process PBCA will select investments for the Funds, in part, on the basis of information and data filed by issuers with various government regulators or made directly available to PBCA by the issuers or through sources other than the issuers, including, but not limited to industry experts, political consultants, sellside analysts and other third-party providers of data products and services. Data sources include among others, those commonly known as “traditional data,” such as information from SEC filings and securities trading price and volume information, and “alternative data,” which generally is understood to refer to data published by sources outside of the issuer or a trading venue that is used to draw insights about a particular issuer, industry or macroeconomic event. Alternative data sets can be compiled from various sources including, but not limited to financial transactions, mobile devices, social media, public records and the internet. Although PBCA will generally evaluate all such information and data and, when PBCA considers it is appropriate and when it is reasonably available, seek independent corroboration, PBCA is not in a position to confirm the completeness, genuineness or accuracy of all such information and data, and in some cases, complete and accurate data and information is not available. As a result, if PBCA draws incorrect conclusions based on its review of the information or data it is evaluating or if such information or data is inaccurate or otherwise not reliable, the Funds’ investments may not perform as expected and the Funds may suffer a loss, including the cost of procuring such information or data, which is often relatively expensive.
Item 7: Types of clients
Currently, PBCA provides investment advice to the Funds and the SMA. Each of the Funds set forth the eligibility criteria and minimum investment requirements for Investors. Initial and additional subscription minimums are disclosed in the Offering Documents for each Fund, which may be waived at the discretion of PBCA. Each Investor generally must be (i) an “accredited investor”, as defined in Regulation D under the U.S. Securities Act of 1933, as amended (the “Securities Act”), and (ii) a “qualified client”, as defined in the Advisers Act. The subscription agreement contains representations and questionnaires relating to these qualifications. The minimum initial investment that will be accepted from a prospective Investor into the Feeder Funds is $5,000,000. The minimum additional capital contribution that will be accepted from an existing Investor is $250,000. In each case, PBCA has discretion to accept lesser amounts. In addition to providing investment management services to the Funds, PBCA may advise other clients in the future that may include additional private funds or separately managed accounts.
Item 6: Performance-based fees and side-by-side management Conflicts of interest
PBCA generally receives performance-based compensation from its Clients pursuant to the Offering Documents of the Funds and the Investment Management Agreement of the SMA. For the Funds, the General Partner will receive an annual performance allocation (“Performance Allocation”) at the close of each fiscal year (or other relevant period referred to below, as the case may be) equal to 20% of the Funds’ net income (including realized and unrealized gains and losses and net of the Management Fee) attributable to each Investor’s capital account for such fiscal year (or other applicable period). Upon any withdrawal by an Investor, whether voluntary or involuntary, the Performance Allocation will be allocated with respect to the amounts withdrawn. The Performance Allocation will also be allocated upon dissolution of one or more of the Funds. The General Partner, in its sole discretion, may waive or reduce the Performance Allocation with respect to one or more Investors (including with respect to PBCA affiliates) for any period of time, or agree to modify the Performance Allocation for that Investor. The Performance Allocation is subject to what is commonly known as a “high water mark” provision. That is, if an Investor’s capital account has a net loss in any fiscal year (or other relevant period, as applicable), this loss will be recorded and carried forward as to such capital account to future fiscal years (or other relevant periods) (such amount is referred to as the “Loss Carryforward”). The General Partner will not receive the Performance Allocation with respect to an Investor’s capital account in any future fiscal year (or other relevant period) until the Loss Carryforward amount for such capital account has been recovered. Once the Loss Carryforward has been recovered, the Performance Allocation will be based on the excess profits (over the Loss Carryforward amount) as to such capital account, rather than on all profits. When an Investor withdraws capital, any Loss Carryforward will be adjusted downward in proportion to the withdrawal. The General Partner may agree with any Investor to apply a different Loss Carryforward provision for such Investor. Certain Investors in the Funds may have a higher management fee or Performance Allocation than other Investors. When PBCA manages more than one Fund or client account, a potential exists for one Fund or client account to be favored over another Fund or client account. PBCA and its investment personnel have a greater incentive to favor a Fund or client account that pays PBCA or the General Partner (and, indirectly, its investment personnel) higher management fees or incentive allocations. However, PBCA has adopted policies and procedures intended to address conflicts of interest that may arise relating to the management of multiple Funds or client accounts, including accounts with different fee arrangements and the allocation of investment opportunities. PBCA reviews investment decisions for the purpose of ensuring that all accounts with substantially similar investment objectives are treated equitably. It is PBCA’s general policy to trade the portfolios of all Funds and client accounts on a pari passu basis based on relative capital (subject to the use of leverage in the portfolios of certain Funds). However, allocations may be made on a basis other than pro rata for a number of reasons, including, but not limited to: a particular Fund’s or client account’s investment guidelines and restrictions; available cash; liquidity requirements; tax or legal reasons; to avoid odd lots; or in cases in which such an allocation would result in a de minimis allocation to a Fund or client account.
Item 10: Other financial industry activities and affiliations Conflicts of interest
Neither PBCA nor the General Partner are registered or have an application pending to register as a broker-dealer or a registered representative of a broker-dealer.
Neither PBCA nor the General Partner are registered or have an application pending to register as a futures commission merchant, commodity pool operator, a commodity trading advisor, or an associated person of the foregoing entities. The General Partner is an affiliated entity of PBCA. Neither PBCA nor the General Partner recommend or select other investment advisers for the Funds.
Item 11: Code of ethics, participation or interest in client transactions and personal trading Conflicts of interest
Trading Code of Ethics PBCA has adopted a Code of Ethics pursuant to Rule 204A-1 of the Advisers Act (the “Code”) that establishes certain standards of conduct and rules for its employees and/or access persons (as applicable). A summary of the Code is provided below. All access persons of PBCA must acknowledge annually that they understand and agree to the terms of the Code. The Code incorporates the following general principles that all employees are expected to uphold at all times: -
Employees must place the interest of clients first;
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Employees must conduct all personal securities transactions in a manner consistent with the Code and seek to avoid both actual conflicts of interest and the appearance thereof, and;
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Employees may not take inappropriate advantage of their own positions with PBCA for their own personal benefit.
Personal Trading The Code provides that access persons must obtain preclearance from the COO/CCO prior to transacting in any individual publicly-traded security for their own accounts or accounts that the access person controls or which the access person may be deemed to have beneficial ownership (such as an account of a spouse or minor child). Further, access persons are prohibited from purchasing individual publicly- traded securities in the healthcare sector, not limited to life sciences. PBCA believes that this mitigates the most likely conflict of interest that may arise from personal trading activity. Access persons are permitted to buy and sell private securities (such as investments in hedge fund, private equity funds and private companies) with prior approval. Access persons are also permitted to invest in exchange traded funds, mutual funds and U.S. and non-U.S. government issued obligations without prior approval. In addition, PBCA may permit access persons to maintain accounts that are managed on a discretionary basis by a third party if the access person has no direct or indirect influence or control over the investments for the account. Exceptions to the personal trading policy are handled on a case-by-case basis. For example, an exception may be granted for legacy positions that were held by an access person (or a covered family member) prior to that access person joining PBCA or to sell an investment that was originally made when the company was private and subsequently became publicly traded. In such a case, the access person would be required to obtain prior approval to sell such positions and may be subject to other restrictions as deemed appropriate by PBCA under the circumstances. Gifts and Entertainment, Political Activities and Outside Activities
The Code provides that gifts and entertainment must be reasonable in light of industry practices and should never be given or received if the purpose is to influence the recipient. PBCA requires access persons to report or receive approval for the receipt or giving of gifts and entertainment under certain circumstances. The Code also generally requires access persons to obtain prior approval before the access person, a spouse or certain other immediate family members makes a political contribution or engages in certain campaign-related fundraising activities. This policy is intended to prevent scenarios whereby an access person may contribute or engage in an activity for the selection of PBCA as an investment adviser for a governmental equity. Finally, the Code provides that, without prior approval, access persons are generally not permitted to engage in certain types of outside business activities. This policy is intended to prevent material conflicts of interest that could arise from an access person’s personal activities. Participation or Interest in Client Transactions PBCA, its principals and employees do not purchase or sell any securities for their own accounts to or from the Funds. However, subject to Funds’ investment guidelines and restrictions, PBCA may affect rebalancing or internal cross transactions. In such cases, PBCA may determine that it would be in the best interests of the Master Fund and one or more other accounts to transfer a security from one account to another (each such transfer, a “Cross Trade”) for a variety of reasons, including tax purposes, liquidity purposes, to rebalance the portfolios of the accounts, or to reduce transaction costs that may arise in an open market transaction. If PBCA decides to engage in a Cross Trade, PBCA will determine that the trade is in the best interests of both of the accounts involved and take steps to ensure that the transaction is consistent with the duty to obtain best execution for each of those accounts. If PBCA is to execute Cross Trades, the Firm intends to do so with the assistance of a broker-dealer that executes and books the transaction at the close of the market on the day of the transaction. Alternatively, a cross transaction between two Funds or clients may occur as an “internal cross”, where PBCA instructs the custodian for the accounts to book the transaction at the price determined in accordance with PBCA’s Valuation Policy. If PBCA effects an internal cross, PBCA will not receive any fee in connection with the completion of the transaction. Additional Considerations From time to time, various potential and actual conflicts of interest may arise from the overall advisory, investment and other activities, partners and personnel in connection with client transactions. PBCA has established written policies and procedures, which contain procedures to monitor and resolve conflicts and will endeavor to resolve conflicts in a manner it deems equitable to the extent possible under the prevailing facts and circumstances.
Item 12: Brokerage practices Conflicts of interest
PBCA has complete discretion in deciding which securities are bought and sold, the amount and price of those securities, the brokers or dealers to be used for a particular transaction, and commissions or markups and markdowns paid. For the purposes of this Item 12, the SMA should also be considered to have the same brokerage practices as the Master Fund. Portfolio transactions for the Master Fund are allocated to brokers and dealers on the basis of numerous factors and not necessarily lowest pricing. Brokers and dealers may provide other services
that are beneficial to PBCA and/or certain Funds or clients, but not beneficial to all accounts. Subject to best execution, in selecting brokers and dealers (including prime brokers) to execute transactions, provide financing and securities on loan, hold cash and short balances and provide other services, PBCA may consider, among other factors that are deemed appropriate to consider under the circumstances, the following: the ability of the brokers and dealers to effect the transaction; the brokers’ or dealers’ facilities, reliability and financial responsibility; and the provision by the brokers of capital introduction, talent introduction, marketing assistance, consulting with respect to technology, operations and equipment, commitment of capital, access to company management and access to deal flow. Accordingly, the prices and commission rates (or dealer markups and markdowns arising in connection with riskless principal transactions) charged to the Master Fund by brokers or dealers in the foregoing circumstances may be higher than those charged by other brokers or dealers that may not offer such services. PBCA need not solicit competitive bids and does not have an obligation to seek the lowest available commission cost or spread. Generally, neither PBCA nor the Master Fund separately compensates any broker or dealer for any of these other services. PBCA maintains policies and procedures to review the quality of executions, including periodic reviews by its investment professionals. Soft Dollar Usage The term “soft dollars” refers to commissions accumulated by brokers based on an investment manager’s transactions, on behalf of its clients, which may be used by the investment manager to acquire various products or services. The use of client commissions, known as soft dollars, to pay for these products and services, including research and brokerage products and services, presents investment managers with potential conflicts of interest and may give incentives for investment managers to use certain brokers without regard to their obligations to their clients. PBCA may use soft dollars generated by the Master Fund’s brokerage transactions to pay for brokerage and research products and services that fall within the safe harbor afforded by Section 28(e) of the Exchange Act (“Section 28(e)”). Section 28(e) provides a “safe harbor” to investment managers who use soft dollars to obtain investment research and brokerage products and services. In order to qualify for the safe harbor, the products or services must provide assistance to the investment manager in the performance of its investment decision-making responsibilities, or must relate to the execution, clearance or settlement of a trade. Trade Aggregation and Allocation Policies and Procedures Although PBCA intends that all trades will be done in the Master Fund, PBCA may advise other private funds or clients in the future. If so, it will be the policy of PBCA to allocate investment opportunities to the Master Fund and to any other accounts on a fair and equitable basis, to the extent practical and in accordance with the Master Fund’s or other accounts’ applicable investment strategies, over a period of time. Investment opportunities will generally be allocated among those accounts for which participation in the respective opportunity is considered appropriate, taking into account, among other considerations: whether the risk-return profile of the proposed investment is consistent with an account’s objectives, the potential for the proposed investment to create an imbalance in an account’s portfolio, the liquidity requirements of an account, potentially adverse tax consequences, regulatory restrictions that would or could limit an account’s ability to participate in a proposed investment, and the need to re-size risk in an account’s portfolio. PBCA will have no obligation to purchase or sell a security for, enter into a transaction on behalf of, or provide an investment opportunity to, the Master Fund or other accounts solely because PBCA purchases or sells the same security for, enters into a transaction on behalf of, or provides an opportunity to, another account or the Master Fund if, in its reasonable opinion, such security,
transaction or investment opportunity does not appear to be suitable, practicable or desirable for the Master Fund or the other account. In particular, when the Master Fund is ramping up its investment or trading strategies, it may receive larger allocations of certain securities than the other accounts in order to obtain its desired risk and portfolio size. Conversely, when other accounts ramp up their investment and trading strategies, the Master Fund may receive reduced or no allocations of certain securities. Trade Errors Trade errors involving transactions in any account directly or indirectly held by the Master Fund or any derivatives contract or other similar agreement of the Master Fund and/or any trading vehicle (each, a “Trade Error”) may occur. Trade Errors include the placement of orders (either purchases or sales) in excess of, or less than, the amount of securities the account intended to trade; the sale of a security when it should have been purchased; the purchase of a security when it should have been sold; the purchase or sale of the wrong security; and the purchase or sale of a security for the wrong account and the post-settlement discovery of such purchase or sale. Trades implemented as a result of faulty data, systems, coding, modeling or analysis, trades that are properly executed but result in losses, errors committed by other persons (including brokers and custodians), or that are otherwise caused by human error other than those specifically described above, are not considered Trade Errors. The loss of an investment opportunity is not considered a Trade Error. Such errors may result in losses or gains. PBCA will use reasonable efforts to detect such errors prior to settlement and promptly correct them. To the extent that an error is caused by a counterparty, such as a broker-dealer, PBCA will use reasonable efforts to recover any losses associated with such error from the counterparty. Pursuant to the exculpation and indemnification provided by the Master Fund and the Feeder Funds to PBCA and its affiliates and personnel, PBCA and its affiliates and personnel will generally not be liable to the Master Fund or the Feeder Funds for any act or omission, absent bad faith, gross negligence, willful misconduct or actual fraud of such person, and the Master Fund and Feeder Funds will generally be required to indemnify such persons against any losses they may incur by reason of any act or omission related to the Master Fund or Feeder Funds, absent bad faith, gross negligence, willful misconduct or actual fraud of such person. As a result of these provisions, the Master Fund and Feeder Funds (and not PBCA) will benefit from any gains resulting from Trade Errors and other errors and will be responsible for any losses (including additional trading costs) resulting from Trade Errors and other errors, absent bad faith, gross negligence, willful misconduct or actual fraud of the relevant person. PBCA will not offset any such gains and losses resulting from Trade Errors and other errors unless the underlying transactions constitute a single transaction or closely related series of transactions. PBCA will reimburse the Master Fund or Feeder Funds for losses for which PBCA is responsible under the exculpation provisions. Given the potentially large volume of transactions executed by PBCA on behalf of the Master Fund, Investors should assume that Trade Errors and other errors will occur and that, to the extent permitted by applicable law and under the Funds’ respective Offering Documents, the Funds will be responsible for any resulting losses, even if such losses result from the negligence (but not gross negligence) of PBCA’s personnel.
Item 14: Client referrals and other compensation Conflicts of interest
Although PBCA does not currently have and does not intend to have any third-party placement agents, PBCA in the future may agree to pay third-party placement agents that refer investors to a Fund. The compensation typically paid to those placement agents includes a portion of the management fee and/or Performance Allocation earned by PBCA in respect of Investors referred to by such placement agents. Investors are generally not subject to any incremental fees in connection with the referral unless incremental fees are payable by the investor directly to the placement agent under the terms of the separate agreement between the investor and the placement agent (to which PBCA is not a party). The referral arrangements described above involve potential conflicts of interest because the placement agent may have an incentive to favor sales of interests in a Fund over sales of other investment products for which the agent will receive no or lower fees. Prospective and existing investors should consider this potential conflict of interest when evaluating any recommendation or referral by an agent regarding an investment in a Fund.
Item 9: Disciplinary information
PBCA has not been subject to any disciplinary action, whether criminal, civil or administrative (including regulatory) in any jurisdiction. Likewise, no persons involved in the management of PBCA have been subject to such action.
Item 13: Review of accounts
PBCA performs daily reviews of the Clients’ portfolios, as well as various other periodic formal and informal reviews. Investors in the Funds generally receive monthly performance summaries, as well as monthly account statements. PBCA may, in its discretion, provide certain investors with additional information on a more frequent basis upon request. In addition, PBCA issues investors tax reports, as well as audited
financial statements concerning their respective Funds within 120 days of the end of each Fund’s fiscal year.
Item 15: Custody
PBCA will comply with the requirements of the Rule 206(4)-2 of the Advisers Act (“Custody Rule”) with regards to PBCA’s custody of the Funds’ assets. PBCA is deemed to have custody of client funds and securities because it has the authority to obtain client funds or securities, for example, by deducting advisory fees from a client's account or otherwise withdrawing funds from the Funds or a client account. PBCA does not expect to be required to comply (or expects to be deemed to have complied) with certain requirements of the Custody Rule with respect to each Fund because it complies with the provisions of the so-called "Pooled Vehicle Annual Audit Exception", which, among other things, requires that (i) each Fund be subject to audit at least annually by an independent public accountant that is registered with, and subject to regular inspection by, the Public Company Accounting Oversight Board (PCAOB), (ii) each Fund’s audited financial statements are prepared in accordance with U.S. GAAP, and (iii) each Fund distributes its audited financial statements to all Investors in the relevant Fund(s) within 120 days of the end of its fiscal year. PBCA is not deemed to have custody of the SMA’s funds and securities.
Item 16: Investment discretion
PBCA has full discretionary authority to manage the Clients, including authority to make decisions with respect to which securities are bought and sold, the amount and price of those securities, the brokers or dealers to be used for a particular transaction, and the commissions paid. PBCA’s authority is limited by its own internal policies and procedures and each Client’s investment guidelines. These terms are set out in the Offering Documents of each Fund and the Investment Management Agreement of the SMA.
Item 17: Voting client securities
Proxy Voting Policies and Procedures PBCA has established proxy voting policies and procedures designed to ensure that proxies, to the extent PBCA has been delegated authority to vote such proxies on behalf of the Funds and elects to
vote, are voted in the best interest of the Clients. When voting proxies, PBCA must identify and address material conflicts that may arise between PBCA’s interests and those of the Clients. Specifically, PBCA monitors the potential for conflicts of interest that might arise from personal relationships that PBCA or its employees may have with parties involved in the vote, significant Investor relationships with those parties, and other special circumstances. PBCA will vote proxies as it deems necessary or appropriate, on a case by case basis. Prior to voting, the COO/CCO will determine whether the conflict is material to the vote and will either resolve the conflict or refer the proxy vote to an outside service for its independent consideration. Investors or clients may also contact PBCA to request a copy of its proxy voting policy. Class Action Participation Procedures To the extent that PBCA has discretion to participate in class action lawsuits filed against companies or issuers in which the Funds are invested, PBCA may participate in such class action lawsuits if it believes that such participation is in the best interest of the Funds on a case-by-case basis.
Item 18: Financial information
PBCA has no financial commitment that impairs its ability to meet contractual and fiduciary commitments to investors and has not been the subject of a bankruptcy proceeding.
Timeline
- Jun 23, 2020Founded Paradigm Biocapital Advisors LP is founded2
Filings
22 filings to the SEC since October 2021: 22 other. The latest 20:
- Aug 28, 2026N-PX EDGAR
- Aug 14, 202613F-HR EDGAR
- May 15, 202613F-HR EDGAR
- Feb 17, 202613F-HR EDGAR
- Nov 14, 202513F-HR EDGAR
- Aug 29, 2025N-PX EDGAR
- Aug 14, 202513F-HR EDGAR
- May 15, 202513F-HR EDGAR
- Feb 14, 202513F-HR EDGAR
- Nov 14, 202413F-HR EDGAR
- Aug 27, 2024N-PX EDGAR
- Aug 14, 202413F-HR EDGAR
- May 15, 202413F-HR EDGAR
- Feb 14, 202413F-HR EDGAR
- Nov 14, 202313F-HR EDGAR
- Aug 14, 202313F-HR EDGAR
- May 15, 202313F-HR EDGAR
- Feb 14, 202313F-HR EDGAR
- Nov 14, 202213F-HR EDGAR
- Aug 15, 202213F-HR EDGAR
The 22 filings since October 2021 can be filtered by form type and year here when JavaScript is on.
Every filing from the last five years, summarized. The full record is on SEC EDGAR.
Stakes it holds
Paradigm Biocapital Advisors LP has told the SEC it owns more than 5% of 37 companies, latest first (Schedules 13D and 13G).
- Obsidian Therapeutics, Inc.SCHEDULE 13G Oct 5, 20265
- Aeglea BioTherapeuticsSCHEDULE 13G Oct 1, 20266
- Tyra Biosciences, Inc.SCHEDULE 13G Sep 17, 20267
- ASSEMBLY BIOSCIENCES, INC.SCHEDULE 13G/A May 11, 2026 to Aug 14, 20268
- Arcellx, Inc.SCHEDULE 13G/A Jul 21, 2023 to Aug 14, 20269
- Edgewise Therapeutics, Inc.SCHEDULE 13G/A Feb 3, 2025 to Aug 14, 202610
- Lexeo Therapeutics, Inc.SCHEDULE 13G/A Nov 20, 2025 to Aug 14, 202611
- Maze Therapeutics, Inc.SCHEDULE 13G/A Apr 1, 2026 to Aug 14, 202612
- Viridian Therapeutics, Inc.\DESCHEDULE 13G/A Feb 14, 2022 to Aug 14, 202613
- Jade Biosciences, Inc.SCHEDULE 13G Jul 17, 202614
- MBX Biosciences, Inc.SCHEDULE 13G Jun 24, 202615
- Erasca, Inc.SCHEDULE 13G/A Jan 14, 2026 to May 15, 202616
- EyePoint PharmaceuticalsSCHEDULE 13G/A Feb 24, 2026 to May 15, 202617
- UroGen Pharma Ltd.SCHEDULE 13G/A Aug 12, 2025 to May 15, 202618
- ACHIEVE LIFE SCIENCES, INC.SCHEDULE 13G Apr 24, 202619
- Merus N.V.SCHEDULE 13G/A Apr 10, 2025 to Feb 17, 202620
- Vor Biopharma Inc.SCHEDULE 13G/A Oct 27, 2022 to Feb 17, 202621
- Agios PharmaceuticalsSCHEDULE 13G/A Aug 28, 2025 to Nov 14, 202522
- Cidara TherapeuticsSCHEDULE 13G/A Jul 30, 2025 to Nov 14, 202523
- Cogent Biosciences, Inc.SCHEDULE 13G/A Feb 12, 2025 to Nov 14, 202524
- LENZ Therapeutics, Inc.SCHEDULE 13G/A Mar 27, 2025 to Nov 14, 202525
- Y-mAbs Therapeutics, Inc.SCHEDULE 13G/A Apr 8, 2024 to Nov 14, 202526
- Janux Therapeutics, Inc.SCHEDULE 13G/A Oct 23, 2024 to Aug 14, 202527
- Disc Medicine, Inc.SCHEDULE 13G/A Sep 25, 2023 to May 15, 202528
- Pliant (United States)SCHEDULE 13G/A Oct 4, 2024 to May 15, 202529
- Kura OncologySCHEDULE 13G/A May 2, 2024 to Feb 14, 202530
- Olema Pharmaceuticals, Inc.SCHEDULE 13G/A Apr 10, 2023 to Feb 14, 202531
- Autolus TherapeuticsSC 13G/A Jul 10, 2023 to Nov 14, 202432
- Bicycle Therapeutics (United Kingdom)SC 13G/A Feb 24, 2023 to Nov 14, 202433
- Compass PathwaysSC 13G/A Jan 2, 2024 to Nov 14, 202434
All 37 companies
- Nuvalent, Inc.SC 13G/A Oct 30, 2023 to Nov 14, 202435
- Tarsus Pharmaceuticals, Inc.SC 13G/A Jan 22, 2024 to Nov 14, 202436
- Alpine Immune SciencesSC 13G/A Oct 3, 2022 to Feb 14, 202437
- Ambrx Biopharma, Inc.SC 13G/A Feb 14, 202438
- Corbus PharmaceuticalsSC 13G Feb 5, 2024 to Feb 14, 202439
- Ambrx Biopharma Cayman, Inc.SC 13G Sep 25, 202340
- Oyster Point Pharma, Inc.SC 13G/A Jul 18, 2022 to Feb 14, 202341
Sources
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