TCRT on Nasdaq
ZIOPHARM Oncology
Publicly held, clinical-stage biopharmaceutical company, based in Boston, founded in 20051
In its 2026 annual report the company says: “We are a preclinical-stage biopharmaceutical company focused on the development of novel, orally administered small-molecule therapeutics for obesity and related metabolic disorders, such as metabolic dysfunction-associated steatotic liver disease (MASLD, a type of fatty liver disease). We were previously a clinical-stage oncology-focused cell therapy company developing adoptive TCR-T cell therapies. We have not generated any product revenue and have incurred significant net losses in each year since our inception.”4 Its shares trade on Nasdaq under the symbol TCRT.1
Price unavailable
Last updated Oct 21, 2026.
Overview
Compare with Processa Pharmaceuticals, Inc., One World Products, Inc. or Aspire-Lakewood Holdings, Inc., or pick any stock.
- TickerTCRT on Nasdaq1
- Industrypharmaceutical industry1
- HeadquartersBoston1
- Websitewww.ziopharm.com
- Incorporated inDE3
- Business address501 E Las Olas Blvd, Suite 300, Fort Lauderdale, Fl 333013
- Filer categoryNon-accelerated filer, Smaller reporting company3
See how the biggest companies compare on our leaderboards
We are a preclinical-stage biopharmaceutical company focused on the development of novel, orally administered small-molecule therapeutics for obesity and related metabolic disorders, such as metabolic dysfunction-associated steatotic liver disease (MASLD, a type of fatty liver disease). The program aims to develop a differentiated, non-hormonal, non-incretin approach, unlike hormone-based treatments like GLP-1 drugs. On March 2, 2026, we announced positive preclinical proof-of-concept data for ALN1003 from two separate studies using a standard diet-induced obesity (DIO) mouse model in male C57BL/6 mice maintained on a high-fat diet (60% of calories from fat). Highlights from these studies include dose-dependent body weight loss with favorable body composition changes, reductions in liver weight, improvement in liver function biomarkers, and improvement in metabolic biomarkers. Collective…4 From its latest annual report
Financials
From the company’s reports to the SEC. Every number links to the filing it came from.
Key numbers, fiscal 2025
Where the money goes
Where each dollar of revenue went, fiscal 2025
- Research and development100¢$1.4M
Out of $5.0K in revenue.5 The company lost money this year.
Financial statements
Every line of the income statement as filed: the last 3 fiscal years, latest first.5
| Period ending | 2025-12-31 | 2024-12-31 | 2023-12-31 |
|---|---|---|---|
| Revenue | $5.0K | $10.0K | |
| Research and development | $1.4M | $362.0K | |
| General and administrative | $2.9M | $4.5M | |
| Total operating expenses | $4.2M | $4.8M | |
| Loss from operations | -$4.2M | -$4.8M | |
| Change in fair value of warrant liability | -$31.0K | $0 | |
| Other income , net | $80.0K | $133.0K | |
| Other income (expense), net | $49.0K | $133.0K | |
| Net loss | -$4.2M | -$4.7M | -$4.7M |
| Earnings per share, Basic | -$2.20 | -$2.92 | |
| Earnings per share, Diluted | -$2.20 | -$2.92 | |
| Weighted average common shares outstanding, basic | 1.9M shares | 1.6M shares | |
| Weighted average common shares outstanding, diluted | 1.9M shares | 1.6M shares |
No quarter-by-quarter statement was filed.
Every line of the balance sheet as filed: the last 3 fiscal years (annual) or 3 quarters (quarterly), latest first.5
| Period ending | 2025-12-31 | 2024-12-31 | 2023-12-31 |
|---|---|---|---|
| Cash and cash equivalents | $1.4M | $1.1M | |
| Receivables | $3.0K | $5.0K | |
| Prepaid expenses and other current assets, current | $600.0K | $1.7M | |
| Total current assets | $2.0M | $2.8M | |
| Property and equipment, net | $91.0K | $0 | |
| Prepaid expenses and other assets, non current | $887.0K | $0 | |
| Total assets | $3.0M | $2.8M | |
| Accounts payable | $613.0K | $516.0K | |
| Accrued expenses | $200.0K | $176.0K | |
| Total current liabilities | $813.0K | $692.0K | |
| Total liabilities | $813.0K | $692.0K | |
| Common stock $0.001 par value; 50,000,000 shares authorized, 2,349,480 and 1,601,252 shares issued and outstanding at December 31, 2025 and at December 31, 2024, respectively | $2.0K | $2.0K | |
| Additional paid-in capital | $926.8M | $922.5M | |
| Accumulated deficit | -$924.6M | -$920.4M | |
| Total stockholders' equity | $2.2M | $2.1M | $6.3M |
| Total liabilities and stockholders' equity | $3.0M | $2.8M | |
| Common stock, par value | $0.00 | $0.00 | |
| Common stock, shares authorized | 50.0M shares | 50.0M shares | |
| Common stock, shares issued | 2.3M shares | 1.6M shares | |
| Common stock, shares outstanding | 2.3M shares | 1.6M shares |
| Period ending | 2025-12-31 | 2024-12-31 | 2023-12-31 |
|---|---|---|---|
| Cash and cash equivalents | $1.4M | $1.1M | |
| Receivables | $3.0K | $5.0K | |
| Prepaid expenses and other current assets, current | $600.0K | $1.7M | |
| Total current assets | $2.0M | $2.8M | |
| Property and equipment, net | $91.0K | $0 | |
| Prepaid expenses and other assets, non current | $887.0K | $0 | |
| Total assets | $3.0M | $2.8M | |
| Accounts payable | $613.0K | $516.0K | |
| Accrued expenses | $200.0K | $176.0K | |
| Total current liabilities | $813.0K | $692.0K | |
| Total liabilities | $813.0K | $692.0K | |
| Common stock $0.001 par value; 50,000,000 shares authorized, 2,349,480 and 1,601,252 shares issued and outstanding at December 31, 2025 and at December 31, 2024, respectively | $2.0K | $2.0K | |
| Additional paid-in capital | $926.8M | $922.5M | |
| Accumulated deficit | -$924.6M | -$920.4M | |
| Total stockholders' equity | $2.2M | $2.1M | $6.3M |
| Total liabilities and stockholders' equity | $3.0M | $2.8M | |
| Common stock, par value | $0.00 | $0.00 | |
| Common stock, shares authorized | 50.0M shares | 50.0M shares | |
| Common stock, shares issued | 2.3M shares | 1.6M shares | |
| Common stock, shares outstanding | 2.3M shares | 1.6M shares |
Cash flow is reported year to date, not quarter by quarter, so there are no separate quarterly figures.
Every line of the cash flow as filed: the last 3 fiscal years, latest first.5
| Period ending | 2025-12-31 | 2024-12-31 | 2023-12-31 |
|---|---|---|---|
| Net loss | -$4.2M | -$4.7M | -$4.7M |
| Depreciation | $7.0K | $2.0K | |
| Change in fair value of warrant liability | $31.0K | $0 | |
| Common stock issued for services rendered | $382.0K | $0 | |
| Stock-based compensation | $414.0K | $435.0K | |
| Receivables | $2.0K | -$4.0K | |
| Prepaid expenses and other current assets | $350.0K | $539.0K | |
| Accounts payable | $97.0K | -$100.0K | |
| Accrued expenses | $24.0K | -$1.2M | |
| Net cash flows from operating activities | -$2.9M | -$5.0M | |
| Purchases of property and equipment | -$98.0K | $0 | |
| Net cash flows from investing activities | -$98.0K | $0 | |
| Proceeds from the issuance of common stock and pre funded warrants, net of offering costs | $1.9M | $0 | |
| Proceeds from sale of Series A-1 preferred stock | $500.0K | $0 | |
| Proceeds from sale of Series A-2 preferred stock | $850.0K | $0 | |
| Net cash flows from financing activities | $3.3M | $0 | |
| Net increase (decrease) in cash, cash equivalents | $294.0K | -$5.0M | |
| Cash paid for interest | $0 | $0 | |
| Recognition of warrant liability in connection with the equity line of credit agreement | $178.0K | $0 | |
| Amounts included in accrued expenses and accounts payable related to property and equipment | $67.0K | $0 |
No quarter-by-quarter statement was filed.
Corporate structure
ZIOPHARM Oncology sits at the top of its group. 1 entity, 1 country on record. Switch between the flow chart and the network, and select any entity to see its details.
Major holders of ZIOPHARM Oncology
- Fairmount Funds Management LLC Filed SCHEDULE 13D on ZIOPHARM Oncology, latest Oct 15, 2026
- Robert W. Postma Filed SCHEDULE 13D/A on ZIOPHARM Oncology, latest Oct 15, 2026 (2 filings since Jul 1, 2025)
- Adrian Price Filed SCHEDULE 13D/A on ZIOPHARM Oncology, latest Mar 5, 2026 (5 filings since Oct 30, 2025)
- Strategic EP, LLC Filed SCHEDULE 13G/A on ZIOPHARM Oncology, latest Oct 16, 2025 (2 filings since Sep 4, 2025)
- PMGC CAPITAL LLC Filed SCHEDULE 13D/A on ZIOPHARM Oncology, latest Sep 5, 2025 (2 filings since May 14, 2025)
- MSD Partners, L.P. Filed SCHEDULE 13G/A on ZIOPHARM Oncology, latest Feb 13, 2025 (4 filings since Feb 14, 2023)
- DISCOVERY CAPITAL MANAGEMENT, LLC / CT Filed SC 13G/A on ZIOPHARM Oncology, latest Feb 14, 2024 (3 filings since Feb 14, 2022)
- VANGUARD GROUP INC Filed SC 13G/A on ZIOPHARM Oncology, latest Feb 9, 2023 (2 filings since Feb 10, 2022)
- State Street Corporation Filed SC 13G/A on ZIOPHARM Oncology, latest Jan 20, 2023 (2 filings since Feb 11, 2022)
- BlackRock Filed SC 13G on ZIOPHARM Oncology, latest Jul 8, 2022 (2 filings since Feb 3, 2022)
- Robert D. Hardie Filed SC 13G/A on ZIOPHARM Oncology, latest Feb 11, 2022
- MILLER VALUE PARTNERS, LLC Filed SC 13G/A on ZIOPHARM Oncology, latest Oct 12, 2021
- ZIOPHARM Oncology Boston
Built from major holders from Schedules 13D and 13G. Each entity in the chart links to its source.
What it owns
What ZIOPHARM Oncology reports owning in its annual reports to the SEC: buildings, land and equipment, real estate and locations, investments, intangible assets and inventory, at the end of its latest fiscal year and a year before.
Property and equipment
| Item | Latest | A year before | Change |
|---|---|---|---|
| Property and equipment, before depreciation | $98.0K5 Dec 31, 2025 | $15.0K5 Dec 31, 2024 | +553.3% |
| Accumulated depreciation | $7.0K5 Dec 31, 2025 | $15.0K5 Dec 31, 2024 | −53.3% |
| Property and equipment, net | $91.0K5 Dec 31, 2025 | $05 Dec 31, 2024 |
Investments
Properties, in its own words
Our corporate office is located at 501 E. Las Olas Blvd., Suite 300 Fort Lauderdale, FL 33301. We believe that our existing facilities are adequate to meet our current needs.
Item 2 of the 10-K filed Mar 31, 2026.4
Leadership
Who has led ZIOPHARM Oncology, and when. Pick a name to see everywhere that person has worked.
Chief executive
President
Chief financial officer
Chief operating officer
- Chief executive officerHolger Weis Jul 7, 2025 to now13
- Chief executive officerDale Curtis Hogue Jr. Jan 23, 2024 to Jan 23, 202414
- Chief executive officerHeidi Hagen Mar 8, 2021 to Mar 8, 202115
- Chief executive officerKevin S. Boyle Sr. Aug 31, 2021 to Sep 5, 202316
- Chief executive officerLaurence James Neil Cooper May 7, 2015 to Jan 6, 202117
- PresidentLaurence James Neil Cooper Jan 6, 2021 to Jan 6, 202118
- PresidentDavid M. Mauney Md. Jan 8, 2019 to Jan 31, 202019
- PresidentHagop Youssoufian Jan 3, 2013 to Jan 3, 201320
- PresidentRichard E. Bagley Apr 27, 2006 to Jan 4, 201221
- Chief financial officerTimothy M. Cunningham Feb 26, 2021 to Feb 26, 202122
- Chief financial officerSath Shukla Jul 24, 2019 to Jan 31, 202023
- Chief financial officerJason Amello May 10, 2012 to May 14, 201324
- Chief operating officerCaesar J. Belbel Jun 2, 2015 to Jan 3, 201825
- Chief operating officerRichard E. Bagley Apr 27, 2006 to Jan 4, 201221
Board members and other officers (39)
- OfficerDale Curtis Hogue Jr. Apr 1, 2025 to now26
- Vice President, FinanceFerdinand Groenewald Feb 28, 2024 to now27
- VP, Research & DevelopmentDrew Deniger Apr 8, 2022 to Mar 17, 202328
- OfficerAbhishek K. Srivastava Aug 15, 2022 to Mar 17, 202329
- Chief Medical OfficerRaffaele Baffa Mar 31, 2021 to May 19, 202130
- Senior Vice President, LegalMelinda Lackey Dec 9, 2021 to now31
- EVP, GM Cell TherapyGroot Eleanor De Jun 24, 2019 to Apr 1, 202232
- EVP, GM Gene TherapyJill Buck Jun 24, 2019 to Mar 8, 202133
- EVP and Chief Business OfficerDavid M. Mauney Md. Oct 2, 2017 to Nov 9, 201734
- Executive Vice President R&DFrancois Lebel Feb 17, 2015 to Jan 3, 201835
- Vice Pres., Treasurer, & CAOKevin G. Lafond Jun 12, 2013 to Jan 12, 202136
- Executive VP, CMOHagop Youssoufian Jul 18, 2011 to Jan 4, 201237
- V.P. Chief Medical OfficerBrian Schwartz Apr 2, 2008 to Apr 2, 200838
- Board memberMichael Allen Jerman Jul 17, 2025 to now39
- Board memberDale Curtis Hogue Jr. Jan 3, 2024 to now40
- Board memberRobert Hofmeister Apr 19, 2023 to Jun 10, 202441
- Board memberHolger Weis Mar 22, 2021 to now42
- Board memberJaime Vieser Mar 22, 2021 to now43
- Board memberRobert W. Postma Mar 22, 2021 to now44
- Board memberKevin S. Boyle Sr. Aug 31, 2021 to Sep 5, 202316
- Board memberJ. Kevin Buchi Sep 28, 2020 to May 6, 202145
- Board memberMary Thistle Nov 19, 2020 to Jun 8, 202346
- Board memberLaurence James Neil Cooper Jan 2, 2019 to Jan 6, 202147
- Board memberHeidi Hagen Jun 17, 2019 to Sep 3, 202148
- Board memberChristopher Bowden Oct 15, 2019 to Jun 24, 202249
- Board memberDouglas W. Pagan Sep 20, 2018 to Jan 3, 202050
- Board memberElan Ezickson Sep 20, 2018 to Jan 3, 202051
- Board memberScott Braunstein Sep 20, 2018 to Jan 3, 202052
- Board memberRandal J. Kirk Jan 14, 2011 to Oct 9, 201853
- Board memberGeorge B. Abercrombie Apr 6, 2010 to Apr 6, 201054
- Board memberGary S. Fragin Apr 27, 2006 to Apr 1, 201055
- Board memberMichael Weiser Apr 27, 2006 to Jan 3, 201856
- Board memberRichard E. Bagley Apr 27, 2006 to Jan 4, 201221
- Board memberTimothy McInerney Apr 27, 2006 to Jan 2, 201557
- Board memberWyche Fowler Apr 27, 2006 to Jan 3, 201858
- Board memberJames Anthony Cannon Apr 28, 2006 to May 8, 201959
- Board memberMurray Brennan May 15, 2006 to Jan 3, 201860
- General counselRobert Hadfield Apr 27, 2018 to Mar 8, 202161
- General counselCaesar J. Belbel Sep 6, 2011 to Jan 3, 201862
Former names
Timeline
- Oct 13, 20268-K Entered a material agreement; Completed an acquisition or sale; Unregistered sale of shares63
- Oct 9, 20268-K Listing notice or transfer64
- Sep 22, 20268-K Entered a material agreement; Other events65
- Sep 17, 20268-K Change to shareholders' rights; Bylaws or fiscal year changed66
- Jun 29, 20268-K Other events67
- May 26, 20268-K Other events68
- May 18, 20268-K Other events69
- Apr 15, 20268-K Listing notice or transfer70
- Mar 2, 20268-K Other events71
- Jan 8, 20268-K Ended a material agreement; Change to shareholders' rights; Other events72
- Dec 23, 20258-K Other events73
- Aug 20, 20258-K Other events74
- Jul 7, 2025New chief executive Holger Weis becomes CEO13
- Jan 23, 2024New chief executive Dale Curtis Hogue Jr. becomes CEO14
- Aug 31, 2021New chief executive Kevin S. Boyle Sr. becomes CEO16
- Mar 8, 2021New chief executive Heidi Hagen becomes CEO15
- May 7, 2015New chief executive Laurence James Neil Cooper becomes CEO17
- Nov 9, 2005Went public Listed on NASDAQ1
- Jan 1, 2005Founded Founded1
Calendar
Coming up
- Nov 13, 2026Reports results for the quarter ending Sep/202675
When it reported results
- Oct 10, 2024Reported quarterly or annual results76
- Nov 14, 2023Reported quarterly or annual results77
- Aug 14, 2023Reported quarterly or annual results78
- May 10, 2023Reported quarterly or annual results79
- Mar 7, 2023Reported quarterly or annual results80
- Nov 14, 2022Reported quarterly or annual results81
- Aug 15, 2022Reported quarterly or annual results82
- May 16, 2022Reported quarterly or annual results83
Upcoming dates from Nasdaq's calendar; past results from the company's 8-K filings (Item 2.02). The full markets calendar
Filings
251 filings to the SEC since October 2021: 7 annual reports, 15 quarterly reports, 75 major events, 89 insider forms, 27 large holders, 38 other. The latest 20:
- Oct 15, 20263 EDGAR
- Oct 15, 2026SCHEDULE 13D EDGAR
- Oct 15, 2026SCHEDULE 13D/A EDGAR
- Oct 13, 20268-K EDGAR
- Oct 9, 20268-K EDGAR
- Oct 8, 20264 EDGAR
- Oct 8, 20264 EDGAR
- Oct 8, 20264 EDGAR
- Oct 8, 20264 EDGAR
- Sep 22, 20268-K EDGAR
- Sep 21, 2026424B3 EDGAR
- Sep 17, 20268-K EDGAR
- Aug 14, 202610-Q EDGAR
- Aug 11, 20264 EDGAR
- Jul 27, 20264 EDGAR
- Jul 27, 20264 EDGAR
- Jul 27, 20264 EDGAR
- Jul 27, 20264 EDGAR
- Jul 6, 2026S-8 EDGAR
- Jul 2, 20264 EDGAR
The 251 filings since October 2021 can be filtered by form type and year here when JavaScript is on.
Every filing from the last five years, summarized. The full record is on SEC EDGAR.
Insider trades
7 open-market trades by officers, directors and large owners since October 2021: 4 buys and 3 sales. Grants, option exercises and gifts are left out.
| Date | Who | Trade | Shares | Price | Value | Filing |
|---|---|---|---|---|---|---|
| Dec 31, 2024 | Vieser JaimeDirector | Sale | 3,000 | $2.01 | $6.0K | Form 4 |
| Sep 1, 2023 | Boyle Kevin S. Sr.Chief Executive Officer | Sale | 68,014 | $0.14 | $9.5K | Form 4 |
| Nov 29, 2022 | Postma Robert WDirector | Buy | 750,000 | $0.65 | $487.5K | Form 4 |
| Nov 29, 2022 | Vieser JaimeDirector | Buy | 1,250,000 | $0.65 | $812.5K | Form 4 |
| Dec 22, 2021 | De Groot EleanorEVP, Operations | Sale | 20,132 | $1.27 | $25.6K | Form 4 |
| Nov 17, 2021 | Boyle Kevin S. Sr.Chief Executive Officer | Buy | 9,116 | $1.40 | $12.8K | Form 4 |
| Nov 16, 2021 | Boyle Kevin S. Sr.Chief Executive Officer | Buy | 884 | $1.40 | $1.2K | Form 4 |
From Forms 4 filed with the SEC.
Major holders
Investors who own more than 5% of the shares must tell the SEC: a 13D if they may seek to influence the company, a 13G if they hold passively.
- Fairmount Funds Management LLCSCHEDULE 13D, 1 filing Oct 15, 202684
- Robert W. PostmaSCHEDULE 13D/A, 2 filings Jul 1, 2025 to Oct 15, 202685
- Adrian PriceSCHEDULE 13D/A, 5 filings Oct 30, 2025 to Mar 5, 202686
- Strategic EP, LLCSCHEDULE 13G/A, 2 filings Sep 4, 2025 to Oct 16, 202587
- PMGC CAPITAL LLCSCHEDULE 13D/A, 2 filings May 14, 2025 to Sep 5, 202588
- MSD Partners, L.P.SCHEDULE 13G/A, 4 filings Feb 14, 2023 to Feb 13, 202589
- DISCOVERY CAPITAL MANAGEMENT, LLC / CTSC 13G/A, 3 filings Feb 14, 2022 to Feb 14, 202490
- VANGUARD GROUP INCSC 13G/A, 2 filings Feb 10, 2022 to Feb 9, 202391
- State Street CorporationSC 13G/A, 2 filings Feb 11, 2022 to Jan 20, 202392
- BlackRockSC 13G, 2 filings Feb 3, 2022 to Jul 8, 202293
- Robert D. HardieSC 13G/A, 1 filing Feb 11, 202294
- MILLER VALUE PARTNERS, LLCSC 13G/A, 1 filing Oct 12, 202195
Executive pay
What the company paid its top executives, from the summary compensation table in its proxy statement. Total pay includes salary, bonus, stock and option awards and other pay, as the company valued them.
| Year | Executive | Age | Salary | Total pay |
|---|---|---|---|---|
| 2024 | Melinda Lackey | 48 | $3.1K | $430.4K96 |
| 2024 | Kevin S. BoyleSr. | $317.5K | $392.5K96 | |
| 2024 | Dale Curtis HogueJr. | 56 | $234.0K | $308.3K96 |
| 2024 | Ferdinand Groenewald | 40 | $3.1K | $162.3K96 |
| 2023 | Former ChiefExecutive Officer | $617.8K | $2.0M96 | |
| 2023 | Legal & AdministrationCorporate Secretary | $312.1K | $831.7K96 | |
| 2023 | Drew Deniger | $317.8K | $733.4K96 | |
| 2023 | Interim ChiefExecutive Officer | $11.1K | $48.2K96 |
Held by these funds
The largest holders among investment managers' 13F reports for the quarter ending Jun 30, 2026, the top 25 of 29. Change is in shares since the quarter before.
13F reports cover disclosed long positions in U.S. stocks only.
SEC filer profile
How ZIOPHARM Oncology is registered with the Securities and Exchange Commission, from its EDGAR record and the cover page of its latest annual report.
- Name on EDGARAlaunos Therapeutics, Inc.2
- CIK0001107421
- Employer ID (EIN)84-14756424
- Filer statusNon- accelerated filer not an emerging growth company; a smaller reporting company; not a shell company4
- Incorporated inDelaware4
- Fiscal year endsDecember 312
- Industry code (SIC)2834 Pharmaceutical Preparations2
- SEC reviewing officeOffice of Life Sciences, Division of Corporation Finance2
- Business address501 E Las Olas Blvd, Suite 300, Fort Lauderdale, FL 333012
- Phone(346) 355-40992
- Shares outstanding2,540,480 as of Aug 14, 202612
- Public float$9.6M as of Jun 30, 20254
- AuditorCherry Bekaert LLP, Tampa, Florida PCAOB ID 677; no auditor attestation of internal control over financial reporting4
- On EDGAR sinceFeb 13, 20012
- Filings1,294 in all: 4 (405), 8-K (352), 10-Q (56), 3 (53), SC 13G/A (52), SC 13G (35), DEFA14A (32), DEF 14A (21)2
All 61 form types
10QSB (20), 424B3 (19), 10-K (18), 424B5 (18), UPLOAD (18), DFAN14A (16), CORRESP (15), S-8 (13), SC 13D/A (12), EFFECT (10), S-3 (10), D (8), PRE 14A (8), 10KSB (7), S-3/A (7), 10-K/A (6), 8-K/A (6), CT ORDER (6), SCHEDULE 13D/A (6), 4/A (5), 10SB12G/A (4), SC 13D (4), SCHEDULE 13D (4), 10-Q/A (3), PRRN14A (3), 144 (2), 424B7 (2), ARS (2), DEFC14A (2), FWP (2), NT 10-K (2), NT 10-Q (2), POS AM (2), PREC14A (2), REGDEX (2), S-3ASR (2), SB-2 (2), SCHEDULE 13G/A (2), SEC STAFF LETTER (2), 10KSB/A (1), 10SB12G (1), 3/A (1), 424B8 (1), 5 (1), 8-A12B (1), CERTNAS (1), DFRN14A (1), PRER14A (1), S-1 (1), S-3MEF (1), SB-2/A (1), SC 14F1 (1), SCHEDULE 13G (1)
- Latest filingsAnnual report (10-K) Mar 31, 2026
Quarterly report (10-Q) Aug 14, 2026
Proxy statement (DEF 14A) May 21, 2025
Latest 8-K (8-K) Oct 13, 2026
Securities registered for trading
| Class | Symbol | Exchange |
|---|---|---|
| Common Stock | TCRT | The Nasdaq |
From the cover page of the 10-K filed Mar 31, 2026 (Section 12(b) of the Exchange Act).4
Risk factors and legal proceedings
The risks ZIOPHARM Oncology names in Item 1A of its 10-K filed Mar 31, 2026: 39 risks under these headings, as written.4
- RISKS RELATED TO OUR REPRIORITIZATION, FINANCIAL POSITION AND CAPITAL REQUIREMENTS
- *Our strategic reprioritization to progress our Obesity and Metabolic Program may not be successful, may not yield the desired results and we may be unsuccessful in identifying and implementing any alternate strategic transaction.
- *We will require substantial additional financial resources to continue as a going concern and to advance our Obesity and Metabolic Program, and if we raise additional funds, this may materially and negatively affect the value of your investment in our common stock.
- We have incurred significant operating losses since our inception and expect to incur significant losses for the foreseeable future.
- Raising additional capital in the future may cause dilution to our stockholders, restrict our operations or require us to relinquish rights to product candidates or our technology. In addition, the issuance of shares of common stock upon the exercise of our outstanding prefunded warrants or common stock warrants will result in immediate and substantial dilution to our existing stockholders.
- If we are unable to successfully advance our obesity and metabolic disorders program or raise sufficient additional capital, our Board of Directors may ultimately decide to pursue a dissolution and liquidation.
- RISKS RELATED TO OUR BUSINESS
- * We are currently deficient under Nasdaq’s stockholders’ equity continued listing requirement and remain at risk of delisting, which could materially harm our liquidity, stock price, and ability to consummate strategic transactions.
- *We have identified a material weakness and may identify more in the future or otherwise fail to maintain an effective system of internal controls, which may result in material misstatements of our financial statements or could have a material adverse effect on our business and trading price of our securities.
- We have no products approved for commercial sale and have not generated any revenue from product sales. We may never generate any revenue from product sales or become profitable and, if we achieve profitability, we may not be able to sustain it.
- Our obesity program is in an early preclinical stage and faces significant risks as we progress through additional animal studies and pursue a pathway to conducting IND enabling studies. We may never be able to advance the program to an IND filing, commercialize any product candidate, generate significant revenues, or attain profitability.
- Our business is highly dependent on the success of our Obesity and Metabolic Disorders Program, which is in the early stages of development and will require significant additional preclinical and clinical development before we can seek regulatory approval for and commercially launch a product.
The other 29 risks
- Preclinical development is uncertain. Our preclinical programs may experience delays or may never advance to clinical trials, which would adversely affect our ability to obtain regulatory approvals or commercialize these programs on a timely basis or at all, which would have an adverse effect on our business.
- *Our reliance on third parties to formulate, manufacture and perform preclinical assays on our product candidates exposes us to a number of risks that may delay the development, regulatory approval and commercialization of our products or result in higher product costs.
- We face competition from entities that have developed or may develop programs for the medical needs we plan to address with our Obesity and Metabolic Disorders Program.
- Our operating history makes it difficult to evaluate our business and prospects.
- Our business subjects us to the risk of liability claims associated with the use of hazardous materials and chemicals.
- We may incur substantial liabilities and may be required to limit commercialization of our products in response to product liability lawsuits.
- Our legacy TCR-T cell therapy programs and related intellectual property are no longer in active development and may not generate any meaningful value.
- *Business disruptions could seriously harm our future revenue and financial condition and increase our costs and expenses.
- Our ability to advance our Obesity and Metabolic Disorders Program depends on our ability to retain our remaining employee and consultants.
- Any future growth would impose significant added responsibilities on members of management, including the need to identify, recruit, maintain and integrate additional employees.
- We may become involved in litigation, including securities class action litigation, that could divert management’s attention and harm the Company’s business, and insurance coverage may not be sufficient to cover all costs and damages.
- * Artificial intelligence and other advanced technologies used by us, our employees, consultants, or business partners may expose us to significant risks, including the loss or unauthorized disclosure of confidential information, intellectual property, or clinical and preclinical data, while the rapidly evolving regulatory and legal landscape surrounding artificial intelligence could materially and adversely affect our business.
- *Cybersecurity incidents or IT failures could compromise sensitive information, disrupt operations, or reduce the value of our assets and impair our strategic alternatives.
- RISKS RELATED TO OUR INTELLECTUAL PROPERTY
- If we or our licensors fail to adequately protect or enforce our intellectual property rights or secure rights to patents of others, the value of our intellectual property rights would diminish and our ability to successfully develop our product candidates may be materially impaired.
- If we are unable to protect the confidentiality of our confidential information, our business and competitive position would be significantly harmed.
- Third-party claims of intellectual property infringement would require us to spend significant time and money and could prevent us from developing or commercializing our products.
- Obtaining and maintaining our patent protection depends on compliance with various procedural, document submission, fee payment and other requirements imposed by governmental patent agencies, and our patent protection could be reduced or eliminated for noncompliance with these requirements.
- We may be subject to claims by third parties asserting that our employee or we have misappropriated their intellectual property or claiming ownership of what we regard as our own intellectual property.
- RISKS RELATED TO STOCK OWNERSHIP IN OUR COMPANY AND OTHER RISKS
- Our stock price has been, and may continue to be, volatile.
- Anti-takeover provisions in our charter documents and under Delaware law may make an acquisition of us, which may be beneficial to our stockholders, more difficult.
- Our amended and restated bylaws provide that the Court of Chancery of the State of Delaware will be the exclusive forum for substantially all disputes between us and our stockholders, which could limit our stockholders’ ability to obtain a favorable judicial forum for disputes with us or our directors, officers or employees.
- Because we do not expect to pay dividends, you will not realize any income from an investment in our common stock unless and until you sell your shares at a profit.
- Our ability to use net operating loss carryforwards and research tax credits to reduce future tax payments may be limited or restricted.
- If securities' and/or industry analysts' recommendations change adversely or if our business, financial condition, results of operations, cash flows or prospects do not meet their expectations, our stock price and trading volume could significantly decline.
- Our business could be materially and negatively affected as a result of the actions of activist stockholders.
- Our principal stockholders, executive officers and directors have substantial control over the Company, which may prevent you and other stockholders from influencing significant corporate decisions and may significantly harm the market price of our common stock.
- We are a “smaller reporting company,” and the reduced disclosure requirements applicable to smaller reporting companies may make our common stock less attractive to investors.
- *We have issued preferred stock, and future issuances of preferred stock could adversely affect the rights of holders of our common stock.
- *Ineffective investor relations and public relations efforts could harm our reputation, stock price, and ability to attract capital or strategic partners.
Legal proceedings
In the ordinary course of business, we may periodically become subject to legal proceedings and claims arising in connection with ongoing business activities. The results of litigation and claims cannot be predicted with certainty, and unfavorable resolutions are possible and could materially affect our business, financial condition, results of operations, cash flows and prospects. In addition, regardless of the outcome, litigation could have a material and adverse impact on us because of defense costs, diversion of management resources and other factors.
We do not have any pending litigation that, separately or in the aggregate, would, in the opinion of management, be reasonably likely to have a material adverse effect on our business, financial condition, results of operations, cash flows or prospects.
The opening of Item 3, Legal Proceedings.4
Links
- Websitewww.ziopharm.com1
- WikidataQ17125902
- SEC EDGARCIK 1107421
Sources
The numbers on this page point here. Each one links to the record it came from.
- 1WikidataZIOPHARM Oncology on Wikidata
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13SEC EDGARHolger Weis, Chief executive officer
- 14
- 15SEC EDGARHeidi Hagen, Chief executive officer
- 16
- 17
- 18
- 19SEC EDGARDavid M. Mauney Md., President
- 20SEC EDGARHagop Youssoufian, President
- 21SEC EDGARRichard E. Bagley, President
- 22
- 23SEC EDGARSath Shukla, Chief financial officer
- 24
- 25
- 26SEC EDGARDale Curtis Hogue Jr., Officer
- 27
- 28
- 29SEC EDGARAbhishek K. Srivastava, Officer
- 30
- 31
- 32
- 33SEC EDGARJill Buck, EVP, GM Gene Therapy
- 34
- 35
- 36
- 37SEC EDGARHagop Youssoufian, Executive VP, CMO
- 38
- 39SEC EDGARMichael Allen Jerman, Board member
- 40SEC EDGARDale Curtis Hogue Jr., Board member
- 41SEC EDGARRobert Hofmeister, Board member
- 42SEC EDGARHolger Weis, Board member
- 43SEC EDGARJaime Vieser, Board member
- 44SEC EDGARRobert W. Postma, Board member
- 45SEC EDGARJ. Kevin Buchi, Board member
- 46SEC EDGARMary Thistle, Board member
- 47
- 48SEC EDGARHeidi Hagen, Board member
- 49SEC EDGARChristopher Bowden, Board member
- 50SEC EDGARDouglas W. Pagan, Board member
- 51SEC EDGARElan Ezickson, Board member
- 52SEC EDGARScott Braunstein, Board member
- 53SEC EDGARRandal J. Kirk, Board member
- 54SEC EDGARGeorge B. Abercrombie, Board member
- 55SEC EDGARGary S. Fragin, Board member
- 56SEC EDGARMichael Weiser, Board member
- 57SEC EDGARTimothy McInerney, Board member
- 58SEC EDGARWyche Fowler, Board member
- 59SEC EDGARJames Anthony Cannon, Board member
- 60SEC EDGARMurray Brennan, Board member
- 61SEC EDGARRobert Hadfield, General counsel
- 62SEC EDGARCaesar J. Belbel, General counsel
- 63
- 64SEC EDGARListing notice or transfer
- 65
- 66
- 67SEC EDGAROther events
- 68SEC EDGAROther events
- 69SEC EDGAROther events
- 70SEC EDGARListing notice or transfer
- 71SEC EDGAROther events
- 72
- 73SEC EDGAROther events
- 74SEC EDGAROther events
- 75NasdaqNasdaq calendar
- 76
- 77
- 78
- 79
- 80
- 81
- 82
- 83
- 84
- 85
- 86
- 87
- 88
- 89
- 90
- 91
- 92
- 93
- 94
- 95
- 96