LGND on Nasdaq

LIGAND PHARMACEUTICALS INC

In its 2026 annual report the company says: “We are a biopharmaceutical royalty company focused on deploying capital and licensing technologies to acquire and create diversified royalty streams from high-value medicines. Our primary business is investing in and structuring royalty interests in mid- to late-stage development and commercial biopharmaceutical products, allowing us to generate long-duration, non-dilutive cash flows supported by a lean corporate cost structure.”4 It is headquartered in San Diego, California.1 Its shares trade on Nasdaq under the symbol LGND.1

Price unavailable

Last updated Oct 21, 2026.

Overview

Compare with Vireo Growth Inc., Harrow Health or Arvinas (United States), or pick any stock.

  • TickerLGND on Nasdaq1
  • IndustryPharmaceutical Preparations1
  • HeadquartersSan Diego, California1
  • Incorporated inDE2
  • Business address3911 Sorrento Valley Blvd, Suite 110, San Diego, Ca 921212
  • Filer categoryLarge accelerated filer2

We are a biopharmaceutical royalty company focused on deploying capital and licensing technologies to acquire and create diversified royalty streams from high-value medicines. Our primary business is investing in and structuring royalty interests in mid- to late-stage development and commercial biopharmaceutical products, allowing us to generate long-duration, non-dilutive cash flows supported by a lean corporate cost structure. Capital deployment and technology licensing are the primary drivers of our long-term growth.4 From its latest annual report

Financials

From the company’s reports to the SEC. Every number links to the filing it came from.

Key numbers, fiscal 2025

15.3%Operating margin5
46.4%Net margin5
60.4%Revenue growth, 20255
12.2%Return on equity5
$48.9MFree cash flow5

What sells

Revenue by product, business segment and region, as the company reports it to the SEC.

Products and services

Material Sales, Captisol, Core brought in 18% of the revenue LIGAND PHARMACEUTICALS INC broke down this way in fiscal 2025.

  1. Material Sales, Captisol, Core$40.2M518%up 30% from 2024
  2. Royalty, Kyprolis$35.5M516%down 7% from 2024
  3. Filspari$32.0M514%up 163% from 2024
  4. Financial Royalty Assets$28.5M513%up 112% from 2024
  5. Qarziba$23.7M511%up 113% from 2024
  6. Royalty, Rylaze$13.3M56%down 3% from 2024
  7. Royalty, Other$10.4M55%up 38% from 2024
  8. Capvaxive$10.1M54%up 1507% from 2024
  9. Ohtuvayre$9.8M54%up 1072% from 2024
  10. Royalty, Teriparatide Injection$8.1M54%down 1% from 2024
  11. Vaxneuvance$7.4M53%up 43% from 2024
  12. License Fees$7.0M53%up 259% from 2024
Products and services by year
Products and services202320242025
Material Sales, Captisol, Core$28.4M$30.9M$40.2M
Royalty, Kyprolis$35.6M$38.4M$35.5M
Filspari$2.7M$12.2M$32.0M
Financial Royalty Assets$1.0M$13.4M$28.5M
Qarziba$0$11.1M$23.7M
Royalty, Rylaze$13.5M$13.7M$13.3M
Royalty, Other$6.8M$7.5M$10.4M
Capvaxive$0$626.0K$10.1M
Ohtuvayre$0$833.0K$9.8M
Royalty, Teriparatide Injection$11.1M$8.2M$8.1M
Vaxneuvance$4.1M$5.2M$7.4M
License Fees$0$1.9M$7.0M

Where the money goes

Where each dollar of revenue went, fiscal 2025

  • Research and development30¢$81.2M
  • Other costs10¢$27.9M
  • Income tax13¢$34.5M
  • Profit46¢$124.5M

Out of $268.1M in revenue.5

Where each dollar of operating cash went, fiscal 2025

  • Capital spending1¢$452.0K
  • Share buybacks30¢$15.0M
  • Kept or used elsewhere69¢$33.9M

Out of $49.4M of cash from operations.5

Financial statements

Revenue67895$268.1M in 2025+123% since 2019
0$100.0M$200.0M$300.0M2019: $120.3M$120.3M20192020: $163.6M$163.6M2020+36%2021: $241.5M$241.5M2021+48%2022: $196.2M$196.2M2022−19%2023: $131.3M$131.3M2023−33%2024: $167.1M$167.1M2024+27%2025: $268.1M$268.1M2025+60%
Operating income67895$41.0M in 2025−95% since 2019
-$250.0M0$250.0M$500.0M$750.0M$1.0B2019: $807.1M$807.1M20192020: $37.5M$37.5M2020−95%2021: $103.9M$103.9M2021+177%2022: $3.0M$3.0M2022−97%2023: $11.9M$11.9M2023+293%2024: -$22.6M-$22.6M20242025: $41.0M$41.0M2025
Net income67895$124.5M in 2025−80% since 2019
-$200.0M0$200.0M$400.0M$600.0M$800.0M2019: $629.3M$629.3M20192020: -$3.0M-$3.0M20202021: $57.1M$57.1M20212022: -$33.4M-$33.4M20222023: $52.2M$52.2M20232024: -$4.0M-$4.0M20242025: $124.5M$124.5M2025

Every line of the income statement as filed: the last 3 fiscal years, latest first.5

Period ending2025-12-312024-12-312023-12-31
Total revenue and income$268.1M$167.1M$131.3M
Cost of Captisol$14.5M$11.1M$10.5M
Amortization of intangibles$32.7M$33.0M$33.7M
Research and development$81.2M$21.4M$24.5M
General and administrative$92.4M$78.7M$52.8M
Financial royalty assets impairment$6.2M$30.6M$0
Fair value adjustments to partner program derivatives$0$15.1M$0
Total operating costs and expenses$227.1M$189.7M$121.5M
Gain on sale of Pelican$0$0-$2.1M
Operating income (loss) from continuing operations$41.0M-$22.6M$11.9M
Gain from short-term investments$18.4M$75.0M$46.4M
Gain (loss) from change in fair value of equity method investments and other investments$90.7M-$34.6M$0
Interest income$13.7M$8.1M$7.7M
Interest expense-$4.7M-$3.0M-$656.0K
Other non-operating expense, net-$89.0K-$20.3M-$1.7M
Total non-operating income, net$118.0M$25.1M$51.7M
Income before income tax from continuing operations$159.0M$2.5M$63.7M
Income tax expense-$34.5M-$6.5M-$9.8M
Net income (loss) from continuing operations$124.5M-$4.0M$53.8M
Net loss from discontinued operations-$1.7M
Net income (loss):$124.5M-$4.0M$52.2M
Basic net income (loss) from continuing operations (in USD per share)$6-$0$3
Basic net loss from discontinued operations (in USD per share)$0$0-$0
Basic net income (loss) per share (in USD per share)$6.44-$0.22$3.02
Shares used in basic per share calculation (in shares)19.3M shares18.3M shares17.3M shares
Diluted net income (loss) from continuing operations (in USD per share)$6-$0$3
Diluted net loss from discontinued operations (in USD per share)$0$0-$0
Diluted net income (loss) per share (in USD per share)$6.13-$0.22$2.94
Shares used in diluted per share calculation (in shares)20.3M shares18.3M shares17.8M shares

Compare LIGAND PHARMACEUTICALS INC with another company

Corporate structure

LIGAND PHARMACEUTICALS INC sits at the top of its group. 15 entities, 3 countries on record. Switch between the flow chart and the network, and select any entity to see its details.

Major holders of LIGAND PHARMACEUTICALS INC

  • LIGAND PHARMACEUTICALS INC San Diego, California
    • Pelthos Therapeutics Inc. Stake · Durham, North Carolina
    • Viking Therapeutics Stake · San Diego, California, United States
    • XOMA Royalty Corp Stake · Emeryville, California
    • Apeiron Biologics GmbH Subsidiary · Austria
    • CyDex Pharmaceuticals, Inc. Subsidiary · Delaware, United States
    • Ligand Holdings UK Ltd. Subsidiary · United Kingdom
    • Ligand UK Development Limited Subsidiary · United Kingdom
    • Ligand UK Limited Subsidiary · United Kingdom
    • Metabasis Therapeutics, Inc. Subsidiary · Delaware, United States
    • Neurogen Corporation Subsidiary · Delaware, United States
    • Pfenex Inc. Subsidiary · Delaware, United States
    • Pharmacopeia, LLC Subsidiary · Delaware, United States
    • Seragen, Inc. Subsidiary · Delaware, United States
    • Vernalis Therapeutics, Inc. Subsidiary · Delaware, United States

Built from subsidiaries listed in Exhibit 21 of annual reports filed with the SEC; major holders from Schedules 13D and 13G; stakes of 5% or more it reported on Schedules 13D and 13G (3 companies). Each entity in the chart links to its source.

What it owns

What LIGAND PHARMACEUTICALS INC reports owning in its annual reports to the SEC: buildings, land and equipment, real estate and locations, investments, intangible assets and inventory, at the end of its latest fiscal year and a year before.

Property and equipment

ItemLatestA year beforeChange
Property and equipment, before depreciation$10.1M5 Dec 31, 2025$23.4M5 Dec 31, 2024−56.6%
Accumulated depreciation$6.6M5 Dec 31, 2025$8.3M5 Dec 31, 2024−20.4%
Property and equipment, net$3.6M5 Dec 31, 2025$15.1M5 Dec 31, 2024−76.4%
Finance-lease assets$2.1M5 Dec 31, 2025$2.8M5 Dec 31, 2024−25.1%
Operating-lease assets (leased space)$5.2M5 Dec 31, 2025$6.9M5 Dec 31, 2024−25.4%

Investments

ItemLatestA year beforeChange
Cash and cash equivalents$174.9M5 Dec 31, 2025$72.3M5 Dec 31, 2024+141.9%
Marketable securities, current$558.6M5 Dec 31, 2025$183.9M5 Dec 31, 2024+203.8%
Debt securities available for sale$558.6M5 Dec 31, 2025$183.9M5 Dec 31, 2024+203.8%
Equity securities at fair value$35.2M5 Dec 31, 2025$40.2M5 Dec 31, 2024−12.4%
Stakes in other companies (equity method)$46.5M5 Dec 31, 2025$05 Dec 31, 2024

Intangibles and goodwill

ItemLatestA year beforeChange
Goodwill$101.5M5 Dec 31, 2025$105.2M5 Dec 31, 2024−3.5%
Intangible assets, net (excluding goodwill)$225.4M5 Dec 31, 2025$266.6M5 Dec 31, 2024−15.5%
Finite-lived intangibles, net$225.4M5 Dec 31, 2025$266.6M5 Dec 31, 2024−15.5%

Inventory

ItemLatestA year beforeChange
Inventory, total$9.1M5 Dec 31, 2025$14.1M5 Dec 31, 2024−35.3%

Properties, in its own words

The following table summarizes our principal facilities leased as of December 31, 2025, including the location and size of each facility, and their designated use. We believe our facilities are adequate for our current and near-term needs, and we will be able to locate additional facilities, as needed.

Location · Approximate Square Feet · Operation · Lease Expiration Date

The rest of Item 2

Jupiter, FL · 1,650 · Corporate headquarters · October 2026

San Diego, CA · 6,850 · Office · March 2029

Boston, MA · 9,200 · Office · May 2032

Las Vegas, NV · 4,100 · Office · April 2028

Lawrence, KS · 3,700 · Office and laboratory · August 2032

Item 2 of the 10-K filed Feb 27, 2026.4

Leadership

Who has led LIGAND PHARMACEUTICALS INC, and when. Pick a name to see everywhere that person has worked.

Board members and other officers (37)

Subsidiaries and ownership

Subsidiaries (Exhibit 21)

  • Apeiron Biologics GmbH Austria3
  • CyDex Pharmaceuticals, Inc. Delaware3
  • Ligand Holdings UK Ltd. England and Wales3
  • Ligand UK Development Limited England and Wales3
  • Ligand UK Limited England and Wales3
  • Metabasis Therapeutics, Inc. Delaware3
  • Neurogen Corporation Delaware3
  • Pfenex Inc. Delaware3
  • Pharmacopeia, LLC Delaware3
  • Seragen, Inc. Delaware3
  • Vernalis Therapeutics, Inc. Delaware3

The subsidiaries the company lists in Exhibit 21 of its annual report, as filed.

Former names

  • LIGAND PHARMACEUTICALSSep 13, 1994 to Sep 13, 19942

Timeline

  1. Sep 24, 20268-K Regulation FD disclosure; Other events61
  2. Sep 22, 20268-K Regulation FD disclosure62
  3. Sep 2, 20268-K Financial statements and exhibits63
  4. Aug 6, 20268-K Results of operations64
  5. Jul 14, 20268-K Entered a material agreement; Completed an acquisition or sale; New debt or obligation65
  6. Jun 25, 20268-K Entered a material agreement; New debt or obligation; Unregistered sale of shares66
  7. Jun 22, 20268-K Entered a material agreement; Other events67
  8. Jun 9, 20268-K Executive or director change; Shareholder vote68
  9. May 18, 20268-K Entered a material agreement69
  10. May 7, 20268-K Results of operations70
  11. Apr 30, 20268-K Ended a material agreement71
  12. Apr 27, 20268-K Entered a material agreement; Other events72
  13. Sep 21, 2006New chief executive Henry F. Blissenbach becomes CEO14
  14. Mar 14, 2006New chief executive David E. Robinson becomes CEO13

Calendar

Coming up

  1. Oct 29, 2026 · Before the openReports results for the quarter ending Sep/2026 A year earlier it reported $5.68 a share, on Nov 6, 2025.73

When it reported results

  1. Aug 6, 2026Reported quarterly or annual results64
  2. May 7, 2026Reported quarterly or annual results70
  3. Feb 26, 2026Reported quarterly or annual results74
  4. Nov 6, 2025Reported quarterly or annual results75
  5. Aug 7, 2025Reported quarterly or annual results76
  6. May 8, 2025Reported quarterly or annual results77
  7. Feb 27, 2025Reported quarterly or annual results78
  8. Nov 7, 2024Reported quarterly or annual results79

Upcoming dates from Nasdaq's calendar; past results from the company's 8-K filings (Item 2.02). The full markets calendar

Filings

441 filings to the SEC since October 2021: 5 annual reports, 15 quarterly reports, 70 major events, 222 insider forms, 34 large holders, 95 other. The latest 20:

  1. Oct 6, 20264 EDGAR
  2. Sep 24, 20264 PRIMARY DOCUMENT EDGAR
  3. Sep 24, 20268-K EDGAR
  4. Sep 22, 20268-K EDGAR
  5. Sep 14, 20264 PRIMARY DOCUMENT EDGAR
  6. Sep 10, 2026144 EDGAR
  7. Sep 8, 20264 PRIMARY DOCUMENT EDGAR
  8. Sep 3, 2026144 EDGAR
  9. Sep 2, 20268-K/A EDGAR
  10. Aug 14, 20264 PRIMARY DOCUMENT EDGAR
  11. Aug 14, 20264 PRIMARY DOCUMENT EDGAR
  12. Aug 13, 2026SCHEDULE 13G EDGAR
  13. Aug 12, 2026144 EDGAR
  14. Aug 12, 2026144 EDGAR
  15. Aug 7, 202610-Q EDGAR
  16. Aug 6, 20268-K EDGAR
  17. Aug 4, 20264 PRIMARY DOCUMENT EDGAR
  18. Jul 22, 2026S-8 EDGAR
  19. Jul 14, 20268-K EDGAR
  20. Jul 6, 20264 PRIMARY DOCUMENT EDGAR

The 441 filings since October 2021 can be filtered by form type and year here when JavaScript is on.

Every filing from the last five years, summarized. The full record is on SEC EDGAR.

Insider trades

80 open-market trades by officers, directors and large owners since October 2021: 5 buys and 75 sales. Grants, option exercises and gifts are left out.

DateWhoTradeSharesPriceValueFiling
Sep 10, 2026Zimmermann MartineDirectorSale1,200$285.00$342.0KForm 4
Sep 3, 2026Reardon AndrewCLO & SecretarySale5,000$286.09$1.4MForm 4
Aug 12, 2026Espinoza OctavioChief Financial OfficerSale31,641$292.07$9.2MForm 4
Aug 12, 2026Haas JasonDirectorSale7,138$292.81$2.1MForm 4
Aug 3, 2026Reardon AndrewCLO & SecretarySale5,000$288.99$1.4MForm 4
Jul 1, 2026Reardon AndrewCLO & SecretarySale5,000$313.28$1.6MForm 4
Jun 16, 2026Sabba Stephen LDirectorSale2,145$254.00$544.8KForm 4
Jun 12, 2026Haas JasonDirectorSale6,461$255.58$1.7MForm 4
Jun 11, 2026Aryeh JasonDirectorSale4,500$250.00$1.1MForm 4
Jun 10, 2026Aryeh JasonDirectorSale500$250.00$125.0KForm 4
Jun 10, 2026LAMATTINA JOHN LDirectorSale4,591$250.88$1.2MForm 4
Jun 1, 2026Reardon AndrewCLO & SecretarySale5,000$227.06$1.1MForm 4
May 13, 2026KOZARICH JOHN WDirectorSale1,575$223.50$352.0KForm 4
May 12, 2026KOZARICH JOHN WDirectorSale459$224.00$102.8KForm 4
May 1, 2026KOZARICH JOHN WDirectorSale467$231.80$108.3KForm 4
May 1, 2026Reardon AndrewCLO & SecretarySale5,000$231.31$1.2MForm 4
Apr 1, 2026KOZARICH JOHN WDirectorSale467$202.22$94.4KForm 4
Apr 1, 2026Reardon AndrewCLO & SecretarySale5,000$201.24$1.0MForm 4
Mar 23, 2026Sabba Stephen LDirectorSale1,000$207.87$207.9KForm 4
Mar 11, 2026Espinoza OctavioChief Financial OfficerSale3,057$225.00$687.8KForm 4

All 80 trades can be filtered by person here when JavaScript is on.

From Forms 4 filed with the SEC.

Major holders

Investors who own more than 5% of the shares must tell the SEC: a 13D if they may seek to influence the company, a 13G if they hold passively.

Stakes it holds

LIGAND PHARMACEUTICALS INC has told the SEC it owns more than 5% of 3 companies, latest first (Schedules 13D and 13G).

Executive pay

What the company paid its top executives, from the summary compensation table in its proxy statement. Total pay includes salary, bonus, stock and option awards and other pay, as the company valued them.

YearExecutiveAgeSalaryTotal pay
2025Todd C. Davis65$724.5K$11.5M95
2025Tavo Espinoza$522.8K$4.4M95
2025Andrew Reardon$476.7K$3.7M95
2024Chief Executive Officer$695.8K$12.9M95
2024Chief Financial Officer$469.6K$3.3M95
2024Chief Legal Officer and Secretary$451.9K$3.3M95
2023Chief Executive Officer$650.0K$6.2M95
2023Chief Financial Officer$433.0K$2.5M95
2023Chief Legal Officer and Secretary$434.3K$2.3M95

Held by these funds

The largest holders among investment managers' 13F reports for the quarter ending Jun 30, 2026, the top 25 of 100. Change is in shares since the quarter before.

FundSharesValueShare of the fundChange
BlackRock, Inc.3,100,996$980.2M0.0%+139,073
Invesco Ltd.1,201,644$379.8M0.0%+378,040
Vanguard Portfolio Management LLC1,138,316$359.8M0.0%+38,049
Jupiter Topco LLC1,040,578$328.9M0.1%New
Vanguard Capital Management LLC870,950$275.3M0.0%+22,861
State Street Corp826,539$261.3M0.0%+47,683
Fmr LLC762,827$241.1M0.0%+166,700
Franklin Resources Inc752,044$237.7M0.1%+178,867
Congress Asset Management Co659,911$208.6M1.3%+155,274
Geode Capital Management, LLC589,020$186.2M0.0%+30,086
Nomura Asset Management International Inc.568,371$179.7M0.3%−4,941
Chicago Capital, LLC553,435$174.9M4.2%−8,240
Stephens Investment Management Group LLC475,609$150.3M1.6%−19,061
Dimensional Fund Advisors LP429,314$135.7M0.0%+4,084
Massachusetts Financial Services Co /ma/375,762$118.8M0.0%−35,781
Goldman Sachs Group Inc323,245$102.2M0.0%−57,866
Loomis Sayles & Co L P291,805$92.2M0.1%−61,404
Rice Hall James & Associates, LLC270,052$85.4M4.2%−13,515
Ranger Investment Management, L.P.257,596$81.4M5.2%−10,347
Northern Trust Corp257,389$81.4M0.0%+3,231
Victory Capital Management Inc253,764$80.2M0.0%−49,460
Deutsche Bank Ag\249,611$78.9M0.0%−56,500
Neuberger Berman Group LLC248,355$78.5M0.1%+246,893
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC210,427$66.5M0.0%−2,461
Morgan Stanley200,699$63.4M0.0%+33,470

13F reports cover disclosed long positions in U.S. stocks only.

Members of Congress who traded it

4 trades disclosed by members of Congress. “Vs S&P since” is the stock’s change since the trade minus the S&P 500’s.

DateMemberTradeAmountVs S&P sinceFiling
May 29, 2026Gilbert Ray Cisneros, Jr.Democratic, HouseBuy$1,001 - $15,000+26.7%Report
Mar 3, 2026Gilbert Ray Cisneros, Jr.Democratic, HouseBuy$1,001 - $15,000+32.7%Report
Jan 15, 2026Gilbert Ray Cisneros, Jr.Democratic, HouseBuy$1,001 - $15,000+40.7%Report
Jan 5, 2026Gilbert Ray Cisneros, Jr.Democratic, HouseBuy$1,001 - $15,000+43.2%Report

Members report amounts as ranges, not exact figures. Returns are price-only (no dividends).

SEC filer profile

How LIGAND PHARMACEUTICALS INC is registered with the Securities and Exchange Commission, from its EDGAR record and the cover page of its latest annual report.

  • Name on EDGARLIGAND PHARMACEUTICALS INC1
  • CIK0000886163
  • Employer ID (EIN)77-01607444
  • Filer statusLarge accelerated filer not an emerging growth company; not a smaller reporting company; not a shell company4
  • Incorporated inDelaware4
  • Fiscal year endsDecember 311
  • Industry code (SIC)2834 Pharmaceutical Preparations1
  • SEC reviewing officeOffice of Life Sciences, Division of Corporation Finance1
  • Business address3911 Sorrento Valley Blvd, Suite 110, San Diego, CA 921211
  • Phone858-550-75001
  • Shares outstanding19,935,609 as of Aug 4, 202611
  • Public float$1.6B as of Jun 30, 20254
  • AuditorErnst & Young LLP, San Diego, California PCAOB ID 42; it also attests to the company’s internal control over financial reporting4
  • On EDGAR sinceSep 13, 19941
  • Filings2,284 in all: 4 (912), 8-K (453), SC 13G/A (136), 10-Q (92), 144 (64), SC 13G (64), 425 (47), CT ORDER (44)1
    All 63 form types

    3 (41), SC 13D/A (39), 4/A (36), 424B3 (33), DEF 14A (31), 10-K (30), CORRESP (29), UPLOAD (29), DEFA14A (23), S-8 (19), 8-K/A (18), 10-Q/A (12), SC 13D (12), S-3 (8), NT 10-Q (7), S-3/A (7), SCHEDULE 13G/A (7), 10-K/A (6), ARS (6), POS AM (6), EFFECT (5), 3/A (4), PRE 14A (4), S-1/A (4), S-3ASR (4), S-4 (4), 8-A12G/A (3), PRER14A (3), S-4/A (3), SC TO-T/A (3), SCHEDULE 13G (3), 144/A (2), 424B5 (2), 5 (2), DEFN14A (2), NT 10-K (2), S-1 (2), S-8 POS (2), SC TO-C (2), SCHEDULE 13D (2), 15-12G (1), 424B1 (1), 8-A12B (1), 8-A12G (1), D (1), DEFM14A (1), DFAN14A (1), PREM14A (1), PREN14A (1), SC 13E3 (1), SC 13E3/A (1), SC 13E4 (1), SC 13E4/A (1), SC TO-T (1), SCHEDULE 13D/A (1)

  • Latest filingsAnnual report (10-K) Feb 27, 2026
    Quarterly report (10-Q) Aug 7, 2026
    Proxy statement (DEF 14A) Apr 21, 2026
    Latest 8-K (8-K) Sep 24, 2026

Securities registered for trading

ClassSymbolExchange
Common Stock, par value $0.001 per shareLGNDThe Nasdaq Global Market

From the cover page of the 10-K filed Feb 27, 2026 (Section 12(b) of the Exchange Act).4

Risk factors and legal proceedings

The risks LIGAND PHARMACEUTICALS INC names in Item 1A of its 10-K filed Feb 27, 2026: 64 risks under these headings, as written.4

  • Future revenue based on Kyprolis, Qarziba, Filspari, Evomela, Teriparatide, Vaxneuvance, Ohtuvayre, Capvaxive and Rylaze, as well as royalties from our other partnered products, may be lower than expected.
  • Biopharmaceutical products are subject to sales risks.
  • The royalty market may not grow at the same rate as it has in the past, or at all, and we may not be able to acquire sufficient royalties to sustain the growth of our business.
  • Future revenue from sales of Captisol material to our license partners may be lower than expected.
  • A supply chain interruption may impact our ability to obtain Captisol material.
  • The manufacture and distribution of a biopharmaceutical product may be interrupted by regulatory agencies or supplier deficiencies.
  • Future revenue from royalties on Captisol partnered products may be lower than expected.
  • We rely heavily on collaboration relationships to generate milestone and royalty payments and our collaboration partners have significant discretion when deciding whether to pursue any development program, and any failure by our partners to successfully develop a product candidate or a termination or breach of any of the related agreements could reduce our milestone and license fee revenue, and potentially reduce future royalties.
  • Our collaboration partners may change their strategy or the focus of their development and commercialization efforts with respect to our partnered programs, and the success of our partnered programs could be adversely affected.
  • We may undertake strategic acquisitions of operating biopharmaceutical companies or acquire securities of biopharmaceutical companies. Our failure to realize the expected benefits of such acquisitions could adversely affect our business, financial condition or results of operations.
  • Our product candidates, and the product candidates of our partners, face significant development and regulatory hurdles prior to partnering and/or marketing which could delay or prevent licensing, sales-based royalties and/or milestone revenue.
  • New products and technologies of other companies may render some or all of our or our potential milestone and royalty providers’ product candidates noncompetitive or obsolete.
The other 52 risks
  • We face competition in acquiring existing “passive” royalties and locating suitable passive royalties to acquire.
  • Information available to us about the biopharmaceutical products underlying the royalties we purchase and invest in may be limited and, therefore, our ability to analyze each product and its potential future cash flow may be similarly limited.
  • A significant portion of our future income is dependent upon numerous royalty-specific assumptions and, if these assumptions prove not to be accurate, we may not achieve our expected rates of returns.
  • The insolvency of any of our partners or third-parties who are developing or commercializing products to which we have economic rights could adversely affect our receipt of cash flows on the related milestones or royalties that we own.
  • The commercial success of our product candidates will depend upon the degree of market acceptance by physicians, patients, third-party payers and others in the medical community.
  • The success of our business depends on key members of our team.
  • Third-party intellectual property may prevent us or our partners from developing our potential products; our and our partners’ intellectual property may not prevent competition; and any intellectual property issues may be expensive and time consuming to resolve.
  • If we are unable to obtain and maintain sufficient intellectual property protection for our products, platform and technology, or if the scope of the intellectual property protection obtained is not sufficiently broad, our competitors could develop and commercialize technologies or a platform similar or identical to ours, and our ability to successfully sell our platform and services may be impaired.
  • Issued patents directed to our platform and technology could be found invalid or unenforceable if challenged in court or before administrative bodies in the United States or abroad.
  • The validity, scope and enforceability of any patents that cover our partners’ biologic product candidate can be challenged by third parties.
  • We are typically not involved in maintaining, enforcing and defending patent rights on products that generate our royalties.
  • Changes in patent law in the United States and other jurisdictions could diminish the value of patents in general, thereby impairing our ability to protect our products, platform and technology.
  • We rely on in-licenses from third parties. If we lose these rights, our business may be materially and adversely affected, our ability to develop improvements to our technology platform may be negatively and substantially impacted, and if disputes arise, we may be subjected to future litigation, as well as the potential loss of or limitations on our ability to incorporate the technology covered by these license agreements.
  • We may be subject to claims challenging the inventorship of our patents and other intellectual property.
  • If we are unable to protect the confidentiality of our information and our trade secrets, the value of our technology could be materially and adversely affected and our business could be harmed.
  • Market acceptance and sales of any approved product will depend significantly on the availability and adequacy of coverage and reimbursement from third-party payors and may be affected by existing and future healthcare reform measures.
  • If we or our commercialization partners market products in a manner that violates healthcare laws, we may be subject to civil or criminal penalties.
  • Changes in and actual or perceived failures to comply with applicable data privacy, security and protection laws, regulations, standards and contractual obligations may adversely affect our business, operations and financial performance.
  • The use of Artificial Intelligence (“AI”) present unique risks and challenges that could adversely impact our business.
  • The regulatory approval processes of the FDA and comparable foreign authorities are lengthy, time consuming and inherently unpredictable, and if we or our partners are ultimately unable to obtain regulatory approval for product candidates, our business will be substantially harmed.
  • Pharmaceutical products are subject to ongoing regulatory obligations and continued regulatory review, which may result in significant additional expense.
  • We or our collaboration partners may rely on orphan drug status to develop and commercialize certain of our product candidates, but orphan drug designations may not confer marketing exclusivity or other expected commercial benefits and we or our collaboration partners may not be able to obtain orphan drug designations for our other product candidates.
  • Changes in funding for the FDA and other government agencies could hinder their ability to hire and retain key leadership and other personnel, or otherwise prevent new products and services from being developed or commercialized in a timely manner, which could negatively impact our business or the business of our partners.
  • If plaintiffs bring product liability lawsuits against us or our partners, we or our partners may incur substantial liabilities and may be required to limit commercialization of our approved products and product candidates.
  • We face risks related to handling of hazardous materials and other regulations governing environmental safety.
  • We may also be subject to other laws and regulations not specifically targeting the healthcare industry.
  • Any difficulties from strategic acquisitions and other M&A transactions could adversely affect our stock price, operating results and results of operations.
  • We continue to have exposure to risks related to Pelthos due to our ongoing equity ownership and other investments in Pelthos, which could adversely affect our financial condition and results of operations.
  • Our operating results may fluctuate significantly, which makes our future operating results difficult to predict and could cause our operating results to fall below expectations or any guidance we may provide.
  • Changes or modifications in financial accounting standards, including those related to revenue recognition, may harm our results of operations.
  • Changes in tax laws or regulations that are applied adversely to us may have a material adverse effect on our business, cash flow, financial condition, or results of operations.
  • Our ability to use our net operating loss carryforwards and certain other tax attributes to offset future taxable income may be subject to certain limitations.
  • If the OmniAb Distribution, together with certain related transactions (including the OmniAb Separation), failed to qualify as a reorganization under Sections 355 and 368(a)(1)(D) of the Code, or the OmniAb Merger failed to qualify as a reorganization under Section 368(a) of the Code, we could incur significant tax liabilities.
  • The OmniAb Separation and OmniAb Distribution may expose Ligand to potential liabilities arising out of state and federal fraudulent conveyance laws and legal dividend requirements.
  • The occurrence of a catastrophic disaster could disrupt our business, damage our facilities beyond insurance limits, increase our costs and expenses, or we could lose key data which could cause us to curtail or cease operations.
  • We rely on information technology system and any failure, inadequacy, interruption or security lapse of our information technology systems, including any cyber security incidents, could harm our ability to operate our business effectively.
  • The terms of our Credit Agreement may limit our flexibility in operating our business and adversely affect our financial health and competitive position, and all of our obligations under our Credit Agreement are secured by certain of our collateral and the collateral of certain of our subsidiaries, as Guarantors. If we default on these obligations, our lenders could foreclose on such assets.
  • We use or draw down on our Credit Agreement or use other debt in connection with our capital deployment, which magnifies the potential for loss if the royalties acquired do not generate sufficient income to us.
  • Our ability to satisfy debt obligations depends on our future performance.
  • The Credit Agreement limits our ability to pay any cash amount upon the conversion or repurchase of the 2030 Notes.
  • We may still incur substantially more debt or take other actions which would intensify the risks discussed above.
  • Impairment charges pertaining to goodwill, identifiable intangible assets or other long-lived assets from our mergers and acquisitions could have an adverse impact on our results of operations and the market value of our common stock.
  • Our investments are subject to market and credit risks that could diminish their value and these risks could be greater during periods of extreme volatility or disruption in the financial and credit markets, which could adversely impact our business, financial condition, results of operations, liquidity and cash flows.
  • If we were determined to be an investment company under the U.S. Investment Company Act of 1940, applicable restrictions could make it impractical for us to continue our business as contemplated and could adversely affect our business, financial condition or results of operations.
  • Our charter documents and concentration of ownership may hinder or prevent change of control transactions.
  • Our amended and restated bylaws provide that the Court of Chancery of the State of Delaware will be the exclusive forum for substantially all disputes between us and our stockholders, which could limit our stockholders’ ability to obtain a favorable judicial forum for disputes with us or our directors, officers or employees.
  • Our stock price has been volatile and could experience a sudden decline in value.
  • Unfavorable global economic and political conditions could adversely affect our business, financial condition or results of operations.
  • If securities or industry analysts do not publish research reports about our business or if they make adverse recommendations regarding an investment in our stock, our stock price and trading volume may decline.
  • Cyber-attacks or other failures in telecommunications or information technology systems could result in information theft, data corruption and significant disruption of our business operations.
  • The biopharmaceutical industry may be negatively affected by federal government deficit reduction policies, which could reduce the value of the royalties that we hold.
  • Legal claims and proceedings could adversely affect our business.

Legal proceedings

We record an estimate of a loss when the loss is considered probable and estimable. Where a liability is probable and there is a range of estimated loss and no amount in the range is more likely than any other number in the range, we record the minimum estimated liability related to the claim in accordance with ASC 450, Contingencies. As additional information becomes available, we assess the potential liability related to our pending litigation and revise our estimates. Revisions in our estimates of potential liability could materially impact our results of operations.

On October 31, 2019, we received three civil complaints filed in the U.S. District Court for the Northern District of Ohio on behalf of several Indian tribes. The Northern District of Ohio is the Court that the Judicial Panel on Multi-District Litigation

(“JPML”) has assigned more than one thousand civil cases which have been designated as a Multi-District Litigation (“MDL”) and captioned In Re: National Prescription Opiate Litigation. The allegations in these complaints focus on the activities of defendants other than the Company and no individualized factual allegations have been advanced against us in any of the three complaints. We reject all claims raised in the complaints and intend to vigorously defend these matters.

The opening of Item 3, Legal Proceedings.4

Sources

The numbers on this page point here. Each one links to the record it came from.

  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
  6. 6
  7. 7
  8. 8
  9. 9
  10. 10
  11. 11
  12. 12
  13. 13
  14. 14
  15. 15
  16. 16
  17. 17
  18. 18
  19. 19
  20. 20
  21. 21
  22. 22
  23. 23
  24. 24
  25. 25
  26. 26
  27. 27
  28. 28
  29. 29
  30. 30
  31. 31
  32. 32
  33. 33
  34. 34
  35. 35
  36. 36
  37. 37
  38. 38
  39. 39
  40. 40
  41. 41
  42. 42
  43. 43
  44. 44
  45. 45
  46. 46
  47. 47
  48. 48
  49. 49
  50. 50
  51. 51
  52. 52
  53. 53
  54. 54
  55. 55
  56. 56
  57. 57
  58. 58
  59. 59
  60. 60
  61. 61
  62. 62
  63. 63
  64. 64
  65. 65
  66. 66
  67. 67
  68. 68
  69. 69
  70. 70
  71. 71
  72. 72
  73. 73
  74. 74
  75. 75
  76. 76
  77. 77
  78. 78
  79. 79
  80. 80
  81. 81
  82. 82
  83. 83
  84. 84
  85. 85
  86. 86
  87. 87
  88. 88
  89. 89
  90. 90
  91. 91
  92. 92
  93. 93
  94. 94
  95. 95