ZYME on Nasdaq

Zymeworks

Logo: Unknown author Unknown author, CC BY-SA 4.0, via Wikimedia Commons5

Canadian biotechnology company

Zymeworks Inc. is a publicly held biotechnology company based in Vancouver, British Columbia, that develops protein therapeutics for the treatment of cancer as well as for autoimmune and inflammatory diseases. The products are based upon the company's molecular modeling software for optimizing protein structure.3 Wikipedia text CC BY-SA 4.0

Price unavailable

Last updated Oct 21, 2026.

Overview

2003Founded1

Compare with ZEVRA THERAPEUTICS, INC., Theravance Biopharma, Inc. or ImmunoGen Inc., or pick any stock.

  • TickerZYME on Nasdaq1
  • Industrypharmaceutical industry1
  • HeadquartersVancouver1
  • Websitewww.zymeworks.com
  • Legal formDelaware corporation1
  • LEI894500AHOYAGYLYZJL674
  • StatusActive4
  • LEI statusLapsed (not renewed)4
  • Registered address108 Patriot Drive, Suite A, 19709 Middletown, United States4
  • Registered withDivision of Corporations, Department of State, 67871124

Zymeworks Inc. is a publicly held biotechnology company based in Vancouver,3

Financials

From the company’s reports to the SEC. Every number links to the filing it came from.

Key numbers, fiscal 2025

-87.3%Operating margin7
-76.6%Net margin7
38.9%Revenue growth, 20257
-30.2%Return on equity7
-$34.5MFree cash flow7

Where the money goes

Where each dollar of revenue went, fiscal 2025

  • Other costs99¢$104.6M
  • Income tax1¢$1.4M

Out of $106.0M in revenue.7 The company lost money this year.

Financial statements

Revenue8910117$106.0M in 2025+259% since 2019
0$200.0M$400.0M$600.0M2019: $29.5M$29.5M20192020: $39.0M$39.0M2020+32%2021: $26.7M$26.7M2021−32%2022: $412.5M$412.5M2022+1446%2023: $76.0M$76.0M2023−82%2024: $76.3M$76.3M2024+0%2025: $106.0M$106.0M2025+39%
Operating income8910117-$92.5M in 2025−39% since 2019
-$300.0M-$200.0M-$100.0M0$100.0M$200.0M2019: -$151.3M-$151.3M20192020: -$187.5M-$187.5M2020+24%2021: -$215.6M-$215.6M2021+15%2022: $130.5M$130.5M20222023: -$138.1M-$138.1M20232024: -$137.1M-$137.1M2024−1%2025: -$92.5M-$92.5M2025−33%
Net income8910117-$81.1M in 2025−44% since 2019
-$300.0M-$200.0M-$100.0M0$100.0M$200.0M2019: -$145.4M-$145.4M20192020: -$180.6M-$180.6M2020+24%2021: -$211.8M-$211.8M2021+17%2022: $124.3M$124.3M20222023: -$118.7M-$118.7M20232024: -$122.7M-$122.7M2024+3%2025: -$81.1M-$81.1M2025−34%

Every line of the income statement as filed: the last 3 fiscal years, latest first.7

Period ending2025-12-312024-12-312023-12-31
Research and development collaborations (note 11)$106.0M$76.3M$76.0M
Research and development$137.0M$134.6M$143.6M
General and administrative$61.5M$61.5M$70.4M
Impairment on IPR&D (note 6)$0$17.3M$0
Total operating expenses$198.5M$213.4M$214.1M
Loss from operations-$92.5M-$137.1M-$138.1M
Interest income$13.4M$19.9M$19.7M
Other (expense) income, net (note 12)-$559.0K$558.0K-$894.0K
Total other income, net$12.8M$20.5M$18.8M
Loss before income taxes-$79.8M-$116.6M-$119.2M
Income tax (expense) recovery (note 13)-$1.4M-$6.1M$568.0K
Net loss-$81.1M-$122.7M-$118.7M
Unrealized income (loss) on available for sale securities, net of tax of nil (note 5)$873.0K-$349.0K$56.0K
Total other comprehensive income (loss)$873.0K-$349.0K$56.0K
Comprehensive loss-$80.3M-$123.0M-$118.6M
Basic (in dollars per share)-$1.08-$1.62-$1.72
Diluted (in dollars per share)-$1.08-$1.62-$1.72
Basic (in shares)75.4M shares75.8M shares68.9M shares
Diluted (in shares)75.4M shares75.9M shares68.9M shares
Unrealized loss on available for sale securities, tax$0$0$0

Compare Zymeworks with another company

Corporate structure

Zymeworks sits at the top of its group. 1 entity, 1 country on record. Switch between the flow chart and the network, and select any entity to see its details.

Major holders of Zymeworks

  • Rubric Capital Management LP Filed SCHEDULE 13G/A on Zymeworks, latest May 15, 2026 (3 filings since Nov 13, 2024)
  • PERCEPTIVE ADVISORS LLC Filed SCHEDULE 13G on Zymeworks, latest Apr 15, 2026 (4 filings since Feb 15, 2022)
  • Morgan Stanley Filed SCHEDULE 13G/A on Zymeworks, latest Feb 12, 2026 (5 filings since Feb 11, 2022)
  • EcoR1 Capital, LLC Filed SCHEDULE 13D/A on Zymeworks, latest Nov 19, 2025 (12 filings since Oct 28, 2022)
  • BIOTECHNOLOGY VALUE FUND L P Filed SCHEDULE 13G/A on Zymeworks, latest Nov 14, 2025 (3 filings since Jan 3, 2023)
  • Redmile Group, LLC Filed SCHEDULE 13G/A on Zymeworks, latest Nov 14, 2025 (8 filings since Aug 8, 2022)
  • BlackRock Filed SCHEDULE 13G/A on Zymeworks, latest Jul 16, 2025 (2 filings since Jan 29, 2024)
  • BAKER BROS. ADVISORS LP Filed SC 13G/A on Zymeworks, latest Feb 14, 2024 (3 filings since Feb 14, 2022)
  • Bank of America Filed SC 13G/A on Zymeworks, latest Feb 14, 2023 (2 filings since Jan 31, 2022)
  • EVENTIDE ASSET MANAGEMENT, LLC Filed SC 13G/A on Zymeworks, latest Feb 14, 2023 (2 filings since Feb 14, 2022)
  • Goldman Sachs Filed SC 13G/A on Zymeworks, latest Feb 10, 2023 (2 filings since Feb 11, 2022)
  • Wellington Management Company Filed SC 13G/A on Zymeworks, latest Feb 6, 2023 (2 filings since Feb 4, 2022)
  • Zymeworks Vancouver, British Columbia, Canada

Built from parent and subsidiary links from GLEIF, the Global Legal Entity Identifier Foundation (CC0); major holders from Schedules 13D and 13G. Each entity in the chart links to its source.

What it owns

What Zymeworks reports owning in its annual reports to the SEC: buildings, land and equipment, real estate and locations, investments, intangible assets and inventory, at the end of its latest fiscal year and a year before.

Property and equipment

ItemLatestA year beforeChange
Property and equipment, before depreciation$36.8M8 Dec 31, 2021$22.5M8 Dec 31, 2020+63.6%
Accumulated depreciation$14.1M8 Dec 31, 2021$10.3M8 Dec 31, 2020+36.1%
Property and equipment, net$22.8M8 Dec 31, 2021$12.2M8 Dec 31, 2020+87.0%
Operating-lease assets (leased space)$27.0M8 Dec 31, 2021$5.4M8 Dec 31, 2020+397.1%

Investments

ItemLatestA year beforeChange
Cash and cash equivalents$201.9M8 Dec 31, 2021$242.0M8 Dec 31, 2020−16.6%
Marketable securities, current$50.7M8 Dec 31, 2021$184.3M8 Dec 31, 2020−72.5%
Marketable securities, non-current$718.0K14 Dec 31, 2020$014 Dec 31, 2019
Long-term investments$886.0K8 Dec 31, 2021$25.9M8 Dec 31, 2020−96.6%

Intangibles and goodwill

ItemLatestA year beforeChange
Goodwill$12.0M8 Dec 31, 2021$12.0M8 Dec 31, 20200%
Indefinite-lived intangibles (excluding goodwill)$17.6M8 Dec 31, 2021$17.6M8 Dec 31, 20200%
Finite-lived intangibles, gross$16.4M14 Dec 31, 2020$13.0M14 Dec 31, 2019+26.2%
Accumulated amortization$13.9M8 Dec 31, 2021$11.1M8 Dec 31, 2020+25.2%
Finite-lived intangibles, net$3.8M8 Dec 31, 2021$5.3M8 Dec 31, 2020−27.6%

Leadership

Who has led Zymeworks, and when. Pick a name to see everywhere that person has worked.

Board members and other officers (41)

Named in SEC Form D filings

People the company listed in its private-offering notices.

  • Executive OfficerJeffrey C. Smith named Jan 3, 202462
  • DirectorDerek C. Miller named Jan 3, 202462

Products and brands

  • medication

Listed on Wikidata.1

Subsidiaries and ownership

Subsidiaries (Exhibit 21)

  • Zymeworks Biopharmaceuticals Inc. Washington6
  • Zymeworks Lifesciences Pte. Ltd. Singapore6
  • Zymeworks Management Inc. (UK Establishment) United Kingdom6
  • Zymeworks Pharmaceuticals Limited Ireland6

The subsidiaries the company lists in Exhibit 21 of its annual report, as filed.

Timeline

  1. Sep 23, 20268-K Entered a material agreement; Completed an acquisition or sale; New debt or obligation63
  2. Aug 25, 20268-K Regulation FD disclosure; Other events64
  3. Aug 6, 20268-K Results of operations; Regulation FD disclosure65
  4. Jun 29, 20268-K Entered a material agreement; Regulation FD disclosure66
  5. May 14, 20268-K Regulation FD disclosure; Other events67
  6. May 7, 20268-K Results of operations; Regulation FD disclosure68
  7. Apr 1, 20268-K Executive or director change69
  8. Mar 2, 20268-K Results of operations; Regulation FD disclosure70
  9. Mar 2, 20268-K Entered a material agreement; New debt or obligation; Regulation FD disclosure71
  10. Jan 12, 20268-K Results of operations; Executive or director change; Other events72
  11. Dec 30, 20258-K Shareholder vote73
  12. Nov 18, 20258-K Executive or director change; Regulation FD disclosure; Other events74
  13. Jan 18, 2022New chief executive Kenneth Galbraith becomes CEO15
  14. Jan 2, 2019New chief executive Ali Tehrani becomes CEO17
  15. 2003Founded Founded1

Calendar

Coming up

  1. Nov 5, 2026Reports results for the quarter ending Sep/2026 A year earlier it reported ($0.26) a share, on Nov 6, 2025.75

When it reported results

  1. Aug 6, 2026Reported quarterly or annual results65
  2. May 7, 2026Reported quarterly or annual results68
  3. Mar 2, 2026Reported quarterly or annual results70
  4. Jan 12, 2026Reported quarterly or annual results72
  5. Nov 6, 2025Reported quarterly or annual results76
  6. Aug 7, 2025Reported quarterly or annual results77
  7. May 8, 2025Reported quarterly or annual results78
  8. Mar 5, 2025Reported quarterly or annual results79

Upcoming dates from Nasdaq's calendar; past results from the company's 8-K filings (Item 2.02). The full markets calendar

Filings

454 filings to the SEC since October 2021: 7 annual reports, 15 quarterly reports, 138 major events, 135 insider forms, 59 large holders, 1 private raises, 99 other. The latest 20:

  1. Oct 9, 20264 EDGAR
  2. Oct 9, 2026144 EDGAR
  3. Sep 23, 20268-K EDGAR
  4. Aug 25, 20268-K EDGAR
  5. Aug 6, 202610-Q EDGAR
  6. Aug 6, 20268-K EDGAR
  7. Jul 6, 20264 EDGAR
  8. Jun 29, 20268-K EDGAR
  9. May 15, 20264 EDGAR
  10. May 15, 20263 EDGAR
  11. May 15, 2026SCHEDULE 13G/A EDGAR
  12. May 14, 20268-K EDGAR
  13. May 7, 202610-Q EDGAR
  14. May 7, 20268-K EDGAR
  15. Apr 15, 2026SCHEDULE 13G EDGAR
  16. Apr 10, 20264 EDGAR
  17. Apr 10, 20264 EDGAR
  18. Apr 10, 20263 EDGAR
  19. Apr 10, 20263 EDGAR
  20. Apr 7, 20264 EDGAR

The 454 filings since October 2021 can be filtered by form type and year here when JavaScript is on.

Every filing from the last five years, summarized. The full record is on SEC EDGAR.

Insider trades

3 open-market trades by officers, directors and large owners since October 2021: 1 buys and 2 sales. Grants, option exercises and gifts are left out.

DateWhoTradeSharesPriceValueFiling
Nov 10, 2022Josephson NeilChief Medical OfficerSale2,475$8.10$20.0KForm 4
Mar 10, 2022Klompas Neil AChief Operating OfficerSale2,979$6.88$20.5KForm 4
Jan 7, 2022Josephson NeilChief Medical OfficerBuy5,000$14.28$71.4KForm 4

From Forms 4 filed with the SEC.

Major holders

Investors who own more than 5% of the shares must tell the SEC: a 13D if they may seek to influence the company, a 13G if they hold passively.

Executive pay

What the company paid its top executives, from the summary compensation table in its proxy statement. Total pay includes salary, bonus, stock and option awards and other pay, as the company valued them.

YearExecutiveAgeSalaryTotal pay
2024Kenneth GalbraithCEO , President & Chair63$654.8K$5.3M96
2024Leone PattersonExec. VP, Chief Business Officer & CFO62$161.7K$2.9M96
2023Kenneth GalbraithCEO , President & Chair63$625.5K$3.4M96

Funding

Where the company's money came from, by calendar year: private offerings filed with the SEC, federal grants, loans, contracts and other assistance from USAspending.gov, and PPP loans from the SBA. Each bar links to the records below.

Money received by year$50.0M 2023–2023
Money received by yearMoney received by year, 2023–2023: $50.0M in all. Private raises (Form D) $50.0M.$0$20M$40M$60M2023 · Private raises (Form D): $50.0M2023
Figures by year
YearPrivate raises (Form D)Total
2023$50.0M$50.0M

Private raises

Private offerings the company reported to the SEC on Form D. The amount is what the latest filing says was sold so far, charted in the year of the first sale. Covers filings since Oct 1, 2021.

  1. Dec 28, 2023Raised $50 million in a private offering of equity62 Form D: $50 million offered in all Form D

Held by these funds

The largest holders among investment managers' 13F reports for the quarter ending Jun 30, 2026, the top 25 of 100. Change is in shares since the quarter before.

FundSharesValueShare of the fundChange
EcoR1 Capital, LLC22,970,388$600.4M29.8%No change
Rubric Capital Management LP7,000,000$183.0M1.7%No change
BlackRock, Inc.4,251,030$111.1M0.0%−302,858
Perceptive Advisors LLC4,182,953$109.3M1.7%+672,875
Bvf Inc/il3,649,142$95.4M2.4%−85,000
Assenagon Asset Management S.A.2,504,054$65.5M0.0%+1,776,068
Morgan Stanley2,231,260$58.3M0.0%−249,308
BNP PARIBAS ASSET MANAGEMENT Holding S.A.1,781,116$46.6M0.0%−126,923
Vanguard Capital Management LLC1,558,998$40.8M0.0%−146,582
Nextech Invest Ltd.1,113,946$29.1M1.4%No change
State Street Corp1,088,216$28.4M0.0%+76,439
Dimensional Fund Advisors LP994,955$26.0M0.0%−144,180
Citadel Advisors LLC914,136$23.9M0.0%−235,882
Nomura Asset Management International Inc.889,802$23.3M0.0%New
Fmr LLC702,568$18.4M0.0%+35,415
Geode Capital Management, LLC692,410$18.1M0.0%+32,470
Prosight Management, LP674,434$17.6M3.0%+135,385
Qube Research & Technologies Ltd593,590$15.5M0.0%+81,653
Vanguard Portfolio Management LLC510,032$13.3M0.0%+10,157
Redmile Group, LLC491,654$12.9M0.9%No change
Capricorn Fund Managers Ltd486,529$12.7M1.0%−520,681
Goldman Sachs Group Inc470,822$12.3M0.0%−128,664
Arrowstreet Capital, Limited Partnership418,497$10.9M0.0%−325,401
Deutsche Bank Ag\397,190$10.4M0.0%−524,060
Hillsdale Investment Management Inc.382,922$10.0M0.2%+37,300

13F reports cover disclosed long positions in U.S. stocks only.

SEC filer profile

How Zymeworks is registered with the Securities and Exchange Commission, from its EDGAR record and the cover page of its latest annual report.

  • Name on EDGARZymeworks BC Inc.2
  • CIK0001403752
  • Filer statusLarge accelerated filer2
  • Incorporated inBritish Columbia, Canada2
  • Fiscal year endsDecember 312
  • Industry code (SIC)2834 Pharmaceutical Preparations2
  • Business addressSuite 800 - 114 East 4Th Avenue, Vancouver, A1 V5T 1G42
  • Phone(604) 678-13882
  • Shares outstanding57,892,785 as of Aug 2, 202297
  • Public float$1.6B as of Jun 30, 202198
  • On EDGAR sinceJun 14, 20072
  • Filings516 in all: 8-K (163), 4 (101), 6-K (27), SC 13G/A (24), 3 (21), SC 13G (20), 425 (19), 10-Q (14)2
    All 52 form types

    CT ORDER (14), UPLOAD (9), 424B5 (8), CORRESP (8), D (8), 10-K (5), 8-K/A (5), S-8 (5), S-8 POS (5), EFFECT (4), SC 13D/A (4), 4/A (3), D/A (3), DEF 14A (3), DRS/A (3), DRSLTR (3), SUPPL (3), 25-NSE (2), 8-A12B (2), F-1/A (2), F-10/A (2), S-3ASR (2), SC 13D (2), SEC STAFF LETTER (2), 10-K/A (1), 15-12G (1), 424B4 (1), 424B7 (1), 424B8 (1), 6-K/A (1), CERT (1), CERTNYS (1), DEFM14A (1), DEL AM (1), DRS (1), F-1 (1), F-10 (1), F-10POS (1), F-X (1), POS AM (1), POSASR (1), REGDEX (1), S-3 (1), S-3/A (1)

  • Latest filingsAnnual report (10-K) Feb 24, 2022
    Quarterly report (10-Q) Aug 4, 2022
    Proxy statement (DEF 14A) Mar 23, 2021
    Latest 8-K (8-K) Oct 21, 2022

Sources

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